The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action
Open accessAbstract
OBJECTIVE: Phytoestrogens display an array of pharmacologic properties, and in recent years investigation of their potential as anticancer agents has increased dramatically. In this article we review the published literature related to phytoestrogens and breast cancer as well as suggest the possible mechanisms that may underlie the relationship between phytoestrogens and breast cancer. DATA SOURCES: Electronic searches on phytoestrogens and breast cancer were performed on MEDLINE and EMBASE in June 2007. No date restriction was placed on the electronic search. DATA EXTRACTION: We focused on experimental data from published studies that examined the characteristics of phytoestrogens using in vivo or in vitro models. We also include human intervention studies in this review. DATA SYNTHESIS: We evaluated evidence regarding the possible mechanisms of phytoestrogen action. Discussions of these mechanisms were organized into those activities related to the estrogen receptor, cell growth and proliferation, tumor development, signaling pathways, and estrogen-metabolizing enzymes. CONCLUSIONS: We suggest that despite numerous investigations, the mechanisms of phytoestrogen action in breast cancer have yet to be elucidated. It remains uncertain whether these plant compounds are chemoprotective or whether they may produce adverse outcomes related to breast carcinogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reflections on the Discovery and Significance of Estrogen Receptor β
Koehler, K. F., Helguero, L. A., Haldosén, L.-A., Warner, M., & Gustafsson, J.-A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0027 · Cited by 360
Soya foods and breast cancer risk: A prospective study in Hiroshima and Nagasaki, Japan
Key, T. J., Sharp, G. B., Appleby, P. N., Beral, V, Goodman, M. T., Soda, M., & Mabuchi, K. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690837 · Cited by 262
Harris, D. M., Besselink, E., Henning, S. M., Go, V. L. W., & Heber, D. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000807 · Cited by 231
Badawi, A. F., Cavalieri, E. L., & Rogan, E. G. (2001) · Metabolism · doi:10.1053/meta.2001.25592 · Cited by 184
Cited by
Shanle, E. K., & Xu, W. (2011) · Chemical Research in Toxicology · doi:10.1021/tx100231n · Cited by 522
The potential health effects of dietary phytoestrogens
Rietjens, I. M. C. M., Louisse, J., & Beekmann, K. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13622 · Cited by 490
The molecular targets of resveratrol
Kulkarni, S. S., & Cantó, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.005 · Cited by 477
“phytoestrogenic action of Rsv could support a chemoprotective role in breast cancer, there is also evidence suggesting possible adverse effects [132], likely depending on the distinctive patterns of ERα and ERβ expressions in different cell types.”
BackgroundRisks and benefits of dietary isoflavones for cancer
Andres, S., Abraham, K., Appel, K. E., & Lampen, A. (2011) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.541900 · Cited by 168
Zhao, T.-T., Jin, F., Li, J.-G., Xu, Y.-Y., Dong, H.-T., Liu, Q., Xing, P., Zhu, G.-L., Xu, H., & Miao, Z.-F. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2017.12.006 · Cited by 105
Metadata
- Authors
- Mense, S. M., Hei, T. K., Ganju, R. K., & Bhat, H. K.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-04
- Volume
- 116
- Issue
- 4
- Pages
- 426-433
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2089390770
- Cited by
- 229
- References
- 4
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action. https://app.cochat.ai/papers/10.1289/ehp.10538
- The paper
- Mense, S. M., Hei, T. K., Ganju, R. K., & Bhat, H. K. (2008). Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action. Environmental Health Perspectives. https://doi.org/10.1289/ehp.10538
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
