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Cited by 105Phytoestrogen effects and researchNutritional Studies and DietPhytochemicals and Antioxidant Activities

Dietary isoflavones or isoflavone-rich food intake and breast cancer risk: A meta-analysis of prospective cohort studies

Zhao, Ting-Ting, Jin, Feng, Li, Ji-Guang, Xu, Ying-Ying, Dong, Hui-Ting, Liu, Qun, Xing, Peng, Zhu, Guo-Lian +2 more·2019·Clinical Nutrition
DOI 10.1016/j.clnu.2017.12.006
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Abstract

Background & aims Previous studies implied that dietary isoflavone intake may reduce the risk of developing breast cancer, but some have shown ambiguous results. This study aimed to systematically evaluate and summarize available evidence on the effect dietary isoflavone intake has on the risk of developing breast cancer.Methods PubMed, Embase, and the Cochrane Library were searched for prospective cohort studies published through April 2017 that evaluated the effect of dietary isoflavone intake on the development of breast cancer.Results Sixteen prospective cohort studies, involving 11,169 breast cancer cases and 648,913 participants, were identified and included in our data analysis. The pooled relative risk (RR) of breast cancer was 0.99 for high versus low intake of isoflavones (95% confidence interval [CI], 0.91-1.09; P = 0.876) and 0.99 for moderate versus low intake of isoflavones (95%CI, 0.92-1.05; P = 0.653), with insignificant heterogeneity (P = 0.187 for high versus low, and P = 0.192 for moderate versus low). While a moderate consumption of soy-based foods did not significantly affect breast cancer risk, a high intake of soy-based foods associated with a lower risk of developing breast cancer. Considering specific foods, an increased the risk of developing breast cancer was seen with a moderate intake of formononetin, but no significant associations were found between breast cancer risk and other isoflavone-rich diets.Conclusions The present meta-analysis indicates that women with a high dietary intake of soy foods may experience a statistically significant reduction in breast cancer risk. However, moderate formononetin consumption may increase the risk of developing breast cancer.

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  • A meta-analysis in 2016 and two more in 2019 suggested that soy food intake may be associated with a decrease in the risk of breast cancer and improved breast cancer survival.

    “A meta-analysis in 2016 and two more in 2019 reported similar conclusions and further suggested that soy food intake may be associated with a decrease in the risk of breast cancer and improved breast cancer survival [139,140,141].”

    From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [140]

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Authors
Zhao, T.-T., Jin, F., Li, J.-G., Xu, Y.-Y., Dong, H.-T., Liu, Q., Xing, P., Zhu, G.-L., Xu, H., & Miao, Z.-F.
Affiliations
  • First Hospital of China Medical University (CN)
  • Sheng Jing Hospital (CN)
Corresponding author
Miao, Zhi-Feng
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2019-02
Volume
38
Issue
1
Pages
136-145
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2017.12.006
OpenAlex
W2772817669
Cited by
105
References
44
Citations by year
2026: 1 · 2025: 8 · 2024: 18 · 2023: 12 · 2022: 13 · 2021: 22 · 2020: 14 · 2019: 13 · 2018: 3
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81302125, 81372550)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
dietary isoflavones, breast cancer risk, soy products, formononetin, soy isoflavones, chemoprevention
MeSH terms
Breast Neoplasms, Diet, Humans, Isoflavones, Prospective Studies, Risk, Cohort Studies, Soybean Proteins

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