The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who's at risk?
Open accessAbstract
This article briefly summarizes the epidemiology of the health effects of fine particulate air pollution, provides an early, somewhat speculative, discussion of the contribution of epidemiology to evaluating biologic mechanisms, and evaluates who's at risk or is susceptible to adverse health effects. Based on preliminary epidemiologic evidence, it is speculated that a systemic response to fine particle-induced pulmonary inflammation, including cytokine release and altered cardiac autonomic function, may be part of the pathophysiologic mechanisms or pathways linking particulate pollution with cardiopulmonary disease. The elderly, infants, and persons with chronic cardiopulmonary disease, influenza, or asthma are most susceptible to mortality and serious morbidity effects from short-term acutely elevated exposures. Others are susceptible to less serious health effects such as transient increases in respiratory symptoms, decreased lung function, or other physiologic changes. Chronic exposure studies suggest relatively broad susceptibility to cumulative effects of long-term repeated exposure to fine particulate pollution, resulting in substantive estimates of population average loss of life expectancy in highly polluted environments. Additional knowledge is needed about the specific pollutants or mix of pollutants responsible for the adverse health effects and the biologic mechanisms involved.
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Citations
Cites
An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018
Self-citationNolan, J., Batin, P. D., Andrews, R., Lindsay, S. J., Brooksby, P., Mullen, M., Baig, W., Flapan, A. D., Cowley, A., Prescott, R. J., et al. (1998) · Circulation · doi:10.1161/01.cir.98.15.1510 · Cited by 1,179
Increased plasma viscosity during an air pollution episode: a link to mortality?
Peters, A., Döring, A., Wichmann, H.-E., & Koenig, W. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01211-7 · Cited by 706
Heart rate variability associated with particulate air pollution
Pope, C. A., Verrier, R. L., Lovett, E. G., Larson, A. C., Raizenne, M. E., Kanner, R. E., Schwartz, J., Villegas, G. M., Gold, D. R., & Dockery, D. W. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70014-1 · Cited by 595 · cited 4×
“…declines in lung function; large risk of substantial decrements Hoek et al. 1999 (125) Hypoxemia No clear associations with blood oxygen saturation Pope et al. 1999 1177) Plasma viscosity Increased risk of elevated blood plasma viscosity Peters et al. 1997 1178) Heart rate Increased mean HR and…”
InfluentialSOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY
Kevin L. Dreher, R. H. J. (1997) · Journal of Toxicology and Environmental Health · doi:10.1080/009841097160492 · Cited by 486
The Effect of the Urban Ambient Air Pollution Mix on Daily Mortality Rates in 11 Canadian Cities
Burnett, R. T., Cakmak, S., & Brook, J. R. (1998) · Canadian Journal of Public Health · doi:10.1007/bf03404464 · Cited by 163
Effects of ambient particulate matter and ozone on daily mortality in Rotterdam, the Netherlands
Hoek, G., Schwartz, J. D., Groot, B., & Eilers, P. (1997) · Archives of Environmental Health An International Journal · doi:10.1080/00039899709602224 · Cited by 133
Cited by
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
Self-citationBrook, R. D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Luepker, R., Mittleman, M., Samet, J., Smith, S. C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000128587.30041.c8 · Cited by 2,380
The outdoor air pollution and brain health workshop
Block, M. L., Elder, A., Auten, R. L., Bilbo, S. D., Chen, H., Chen, J.-C., Cory-Slechta, D. A., Costa, D., Diaz-Sanchez, D., Dorman, D. C., et al. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.08.014 · Cited by 539
Bell, M. L., & Davis, D. L. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s3389 · Cited by 469
Air pollutants, oxidative stress and human health
Yang, W., & Omaye, S. T. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.10.005 · Cited by 326
Metadata
- Authors
- Pope, C. A.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-08
- Volume
- 108
- Issue
- suppl 4
- Pages
- 713-723
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W5318797
- Cited by
- 996
- References
- 7
- FWCI
- 22.58
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pope, C. A. (2000). Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who's at risk? Environmental Health Perspectives. https://doi.org/10.1289/ehp.108-1637679
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
