SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY
Abstract
Identification of constituents responsible for the pulmonary toxicity of fugitive combustion emission source particles may provide insight into the adverse health effects associated with exposure to these particles as well as ambient air particulate pollution. Herein, we describe results of studies conducted to identify constituents responsible for the acute lung injury induced by residual oil fly ash (ROFA) and to assess physical-chemical factors that influence the pulmonary toxicity of these constituents. Biochemical and cellular analyses performed on bronchoalveolar lavage fluid obtained from rats following intratracheal instillation of ROFA suspension demonstrated the presence of severe inflammation, an indicator of pulmonary injury, which included recruitment of neutrophils, eosinophils, and monocytes into the airway. A leachate prepared from ROFA, containing predominantly Fe, Ni, V, Ca, Mg, and sulfate, produced similar lung injury to that induced by ROFA suspension. Depletion of Fe, Ni, and V from the ROFA leachate abrogated its pulmonary toxicity. Correspondingly, minimal lung injury was observed in animals exposed to saline-washed ROFA particles. A surrogate transition metal sulfate solution containing Fe, V, and Ni largely reproduced the lung injury induced by ROFA. Metal interactions and pH were found to influence the severity and kinetics of lung injury induced by ROFA and soluble transition metals. These findings provide direct evidence for the role of soluble transition metals in the pulmonary injury induced by the combustion emission source particulate, ROFA.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many particles associated with smoking are heavily laden with micro-particulate iron, which is a substantial contributor to disease as a major catalyst of hydroxyl radical production.
“many of the particles associated with smoking (and also ingested from other sources) are heavily laden with micro-particulate iron, which, as a major catalyst of hydroxyl radical production, undoubtedly is a substantial contributor as well (see e.g. [1373,1384,1396-1400]).”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1397]
Cites
An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018 · see citing works
Oxidative mechanisms in the toxicity of metal ions
Stohs, S. J., & Bagchi, D. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00159-h · Cited by 4,219 · see citing works
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
Libermann, T. A., & Baltimore, D. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.5.2327 · Cited by 1,372 · see citing works
Air Pollution and Hospital Admissions for Cardiovascular Disease in Detroit, Michigan
Schwartz, J. D., & Morris, R. D. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117541 · Cited by 506 · see citing works
NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter
KUNSCH, C. A., & Rosen, C. A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6137-6146.1993 · Cited by 493 · see citing works
Toxic Trace Elements: Preferential Concentration in Respirable Particles
Natusch, D. F. S., Wallace, J. R., & Evans, C. A. (1974) · Science · doi:10.1126/science.183.4121.202 · Cited by 400 · see citing works
Toxic Trace Elements Associated with Airborne Particulate Matter: A Review
Schroeder, W. H., Dobson, M., Kane, D., & Johnson, N. D. (1987) · JAPCA · doi:10.1080/08940630.1987.10466321 · Cited by 321 · see citing works
Burnett, R. T., Dales, R., Krewski, D. R., Vincent, R., Dann, T. F., & Brook, J. R. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117540 · Cited by 317 · see citing works
Mechanisms of Action of Vanadium
Nechay, B. R. (1984) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.24.040184.002441 · Cited by 300 · see citing works
Modes in the size distributions of atmospheric inorganic aerosol
John, W., Wall, S. M., Ondo, J. L., & Winklmayr, W. (1990) · Atmospheric Environment Part A General Topics · doi:10.1016/0960-1686(90)90327-j · Cited by 269 · see citing works
Widmer, U., Manogue, K. R., Cerami, A., & Sherry, B. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.11.4996 · Cited by 251 · see citing works
Measurement of aerosol size distributions for nitrate and major ionic species
Wall, S. M., John, W., & Ondo, J. L. (1988) · Atmospheric Environment (1967) · doi:10.1016/0004-6981(88)90392-7 · Cited by 250 · see citing works
Pritchard, R. J., Ghio, A. J., Lehmann, J. R., Winsett, D. W., Tepper, J. S., Park, P., Gilmour, M. I., Dreher, K. L., & Costa, D. L. (1996) · Inhalation Toxicology · doi:10.3109/08958379609005440 · Cited by 235 · see citing works
Trace metal transformation mechanisms during coal combustion
Linak, W. P., & WENDT, J. O. L. (1994) · Fuel Processing Technology · doi:10.1016/0378-3820(94)90179-1 · Cited by 220 · see citing works
Goebeler, M., Roth, J., Bröcker, E.-B., Sorg, C., & Schulze‐Osthoff, K. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.5.2459 · Cited by 138 · see citing works
Transoral tracheal intubation of rodents using a fiberoptic laryngoscope.
Dl, C., Lehmann, H., Wm, H., & Rt, D. (1986) · PubMed · Cited by 121 · see citing works
Blackwell, T. S., Holden, E. P., Blackwell, T., Delarco, J. E., & Christman, J. W. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.11.4.7917314 · Cited by 112 · see citing works
Associations of PM10 and Airborne Iron With Respiratory Health of Adults Living Near a Steel Factory
Dusseldorp, A., Kruize, H., Brunekreef, B., Hofschreuder, P., de Meer, G., & van Oudvorst, A. B. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.6.8520758 · Cited by 110 · see citing works
Compositions of Particles from Selected Sources in Philadelphia for Receptor Modeling Applications
Olmez, I., Sheffield, A. E., Gordon, G. E., Houck, J. E., Pritchett, L. C., Cooper, J. A., Dzubay, T. G., & Bennett, R. L. (1988) · JAPCA · doi:10.1080/08940630.1988.10466479 · Cited by 99 · see citing works
Mass and Elemental Composition of Fine and Coarse Particles in Six U.S. Cities
Spengler, J. D., & Thurston, G. D. (1983) · Journal of the Air Pollution Control Association · doi:10.1080/00022470.1983.10465707 · Cited by 90 · see citing works
Danoff, T. M., Lalley, P. A., Chang, Y.-W., Heeger, P. S., & Neilson, E. G. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.3.1182 · Cited by 62 · see citing works
Bronchiolitis Obliterans from Exposure to Incinerator Fly Ash
Boswell, R. T., & McCunney, R. J. (1995) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-199507000-00015 · Cited by 53 · see citing works
Pulmonary effects of acute vanadium pentoxide inhalation in monkeys.
Knecht, E. A., Moorman, W. J., Clark, J. C., Lynch, D. W., & Lewis, T. R. (1985) · PubMed · doi:10.1164/arrd.1985.132.6.1181 · Cited by 43 · see citing works
Comparative acute toxicity of four nickel compounds to F344 rat lung*1
Benson, J. M. (1986) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(86)90164-8 · Cited by 40 · see citing works
Persistence of Vanadium Compounds in Lungs after Intratracheal Instillation in Rats
Sharma, R. P., Flora, S. J. S., Drown, D. B., & Oberg, S. G. (1987) · Toxicology and Industrial Health · doi:10.1177/074823378700300304 · Cited by 37 · see citing works
Acute Lung Disease After Exposure to Fly Ash
Cho, K., Cho, Y., Shrivastava, D. K., & Kapre, S. (1994) · CHEST Journal · doi:10.1378/chest.106.1.309 · Cited by 35 · see citing works
Respiratory response of guinea pigs to zinc oxide fume
Amdur, M. O., McCarthy, J. F., & Gill, M. W. (1982) · American Industrial Hygiene Association Journal · doi:10.1080/15298668291410756 · Cited by 32 · see citing works
Trace element interactions affecting pulmonary macrophage cytotoxicity
Fisher, G. L., McNeill, K. L., & Democko, C. J. (1986) · Environmental Research · doi:10.1016/s0013-9351(86)80018-4 · Cited by 29 · see citing works
Lung lesions after combined inhalation of cobalt and nickel
Johansson, A., Curstedt, T., & Camner, P. (1991) · Environmental Research · doi:10.1016/s0013-9351(05)80192-6 · Cited by 21 · see citing works
Geertz, R., Gulyas, H., & Gercken, G. (1994) · Toxicology · doi:10.1016/0300-483x(94)90050-7 · Cited by 20 · see citing works
H2O2 increases expression of pulmonary artery endothelial cell platelet-derived growth factor mRNA
Montisano, D. F., Mann, T., & Spragg, R. G. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.6.2255 · Cited by 17 · see citing works
Su, W. Y., Kodavanti, U. P., Jaskot, R. H., Costa, D. L. D. C., & Dreher, K. L. (1995) · PubMed · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Brown, D. M., Wilson, M., MacNee, W., Stone, V., & Donaldson, K. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9240 · Cited by 1,330 · see citing works
Kelly, F. J., & Fussell, J. C. (2012) · Atmospheric Environment · doi:10.1016/j.atmosenv.2012.06.039 · Cited by 1,286 · see citing works
Combustion Aerosols: Factors Governing Their Size and Composition and Implications to Human Health
Lighty, J. S., Veranth, J. M., & Sarofim, A. F. (2000) · Journal of the Air & Waste Management Association · doi:10.1080/10473289.2000.10464197 · Cited by 1,174 · see citing works
Pope, C. A. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.108-1637679 · Cited by 1,007 · see citing works
Nanoparticles and the Environment
Biswas, P., & Wu, C. (2005) · Journal of the Air & Waste Management Association · doi:10.1080/10473289.2005.10464656 · Cited by 802 · see citing works
Ultrafine (nanometre) particle mediated lung injury
Donaldson, K., Li, X. Y., & MacNee, W. (1998) · Journal of Aerosol Science · doi:10.1016/s0021-8502(97)00464-3 · Cited by 770 · see citing works
van EEDEN, S. F., TAN, W. C., SUWA, T., Mukae, H., Terashima, T., Fujii, T., QUI, D., Vincent, R., & Hogg, J. C. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2010160 · Cited by 699 · see citing works
Air pollution and incidence of cardiac arrhythmia
Peters, A., Liu, E., Verrier, R. L., Schwartz, J., Gold, D. R., Mittleman, M., Baliff, J., Oh, J. A., Allen, G., Monahan, K., et al. (2000) · Epidemiology · doi:10.1097/00001648-200001000-00005 · Cited by 651 · see citing works
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
“[1264] Dreher, K.”
Costa, D. L., & Dreher, K. L. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51053 · Cited by 533 · see citing works
“PM correlate with indicators of inflammation, altered host resistance, macrophage dysfunction, and airway hyperreactivity (13-16), but these studies have not attempted to manipulate mass and metal dosing to directly address this concept.”
BackgroundResultInfluentialSchwarze, P. E., Øvrevik, J., Låg, M., Refsnes, M., Nafstad, P. H. J., Hetland, R. B., & Dybing, E. (2006) · Human & Experimental Toxicology · doi:10.1177/096032706072520 · Cited by 527 · see citing works
Health effects of particles in ambient air
Kappos, A. D., Brückmann, P., Eikmann, T. F., Englert, N., Heinrich, U., Höppe, P., Koch, E., Krause, G. H. M., Kreyling, W. G., Rauchfuss, K., et al. (2004) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00306 · Cited by 498 · see citing works
Carter, J. D., Ghio, A. J., Samet, J. M., & Devlin, R. B. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8254 · Cited by 449 · see citing works
Interactions between Ultrafine Particles and Transition Metals in Vivo and in Vitro
Wilson, M. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9501 · Cited by 439 · see citing works
The innate immune response of the respiratory epithelium: Innate immunity in the airway
Diamond, G., Legarda, D., & Ryan, L. K. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917304.x · Cited by 422 · see citing works
“The physicochemical properties and composition have been described (131), but it is important to note that ROFA was 90% water soluble and was high in ionizable metal content, especially vanadium, nickel, and iron, and had negligible endotoxin content (131, 132).”
BackgroundEffects of Metals within Ambient Air Particulate Matter (PM) on Human Health
Chen, L., & Lippmann, M. (2008) · Inhalation Toxicology · doi:10.1080/08958370802105405 · Cited by 380 · see citing works
“) were similar in ROFA- or metal-exposed animals (Dreher et al., 1997; Kodavanti et al., 1997), the gene expression profile studies suggested that there were more complex interactions between metal constituents than previous studies had implicated.”
BackgroundMethodResultInfluentialThe impacts of combustion emissions on air quality and climate – From coal to biofuels and beyond
Gaffney, J. S., & Marley, N. A. (2009) · Atmospheric Environment · doi:10.1016/j.atmosenv.2008.09.016 · Cited by 377 · see citing works
Ultrafine Particles Affect Experimental Thrombosis in an In Vivo Hamster Model
Nemmar, A., Hoylaerts, M., Hoet, P., Dinsdale, D. D., Smith, T., Xu, H., Vermylen, J., & Nemery, B. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200110-026oc · Cited by 349 · see citing works
Lung Inflammation Induced by Concentrated Ambient Air Particles Is Related to Particle Composition
Saldiva, P. H. N., Clarke, R. W., Coull, B. A., Stearns, R. C., Lawrence, J. E., Murthy, G. G. K., Diaz, E. A., Koutrakis, P., Suh, H. H., Tsuda, A., et al. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2106102 · Cited by 319 · see citing works
Monaci, F., Moni, F., Lanciotti, E., Grechi, D., & Bargagli, R. (2000) · Environmental Pollution · doi:10.1016/s0269-7491(99)00175-x · Cited by 313 · see citing works
Environmental risk factors and allergic bronchial asthma
D’Amato, G., Liccardi, G., D’Amato, M., & Holgate, S. T. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02328.x · Cited by 299 · see citing works
Paper-based analytical devices for environmental analysis
Meredith, N. A., Quinn, C. W., Cate, D. M., Reilly, T. H., Volckens, J., & Henry, C. S. (2016) · The Analyst · doi:10.1039/c5an02572a · Cited by 298 · see citing works
Motor vehicle air pollution and asthma in children: A meta-analysis
Gasana, J., Dillikar, D., Mendy, A., Forno, E., & Vieira, E. R. (2012) · Environmental Research · doi:10.1016/j.envres.2012.05.001 · Cited by 297 · see citing works
“Other metals such as chromium, cobalt, copper, manganese, nickel, titanium, vanadium, and zinc have also been associated with radical activation and lung injury in animal studies (Ghio and Hatch, 1993; Donaldson et al., 1997; Costa and Dreher, 1997; Dreher et al., 1997; Costa et al., 1998).”
BackgroundOsornio-Vargas, Á. R., Bonner, J. C., Alfaro‐Moreno, E., Martínez, L., García-Cuellar, C. M., Rosales, S. P. D. L., Miranda, J., & Rosas, I. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5913 · Cited by 292 · see citing works
“…the differences in cytotoxic effects on proliferating cells, as has been proposed by others using residual oil fly ash particles released from the industrial burning of fuel oil (Dreher et al. 1997) or “real-world” ambient particles collected from urban areas (Dye et al. 2001; Vincent et al. 2001).”
BackgroundAcute pulmonary effects of ultrafine particles in rats and mice.
Oberdörster, G., Finkelstein, J. N., Johnston, C. J., Gelein, R. M., Cox, C., Baggs, R. B., & Elder, A. C. P. (2000) · PubMed · Cited by 287 · see citing works
Riva, D. R., Magalhães, C. B., Lopes, A. A., Lanças, T., Mauad, T., Malm, O., Valença, S. S., Saldiva, P. H. N., Faffe, D. S., & Zin, W. A. (2011) · Inhalation Toxicology · doi:10.3109/08958378.2011.566290 · Cited by 282 · see citing works
“The initial phase of the pulmonary response to PM exposure seems to be influenced by single elements, while a persistent response would reflect complex interactions among different components present in a composite (Dreher et al., 1997; Antonini et al., 2004).”
BackgroundOutdoor air pollution, climatic changes and allergic bronchial asthma
D’Amato, G., Liccardi, G., D’Amato, M., & Cazzola, M. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00401402 · Cited by 275 · see citing works
Zinc Is the Toxic Factor in the Lung Response to an Atmospheric Particulate Sample
Adamson, I. Y. R., Prieditis, H., Hedgecock, C., & Vincent, R. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.8955 · Cited by 270 · see citing works
Systemic Microvascular Dysfunction and Inflammation after Pulmonary Particulate Matter Exposure
Nurkiewicz, T. R., Porter, D. W., Barger, M. W., Millecchia, L., Rao, K. M. K., Marvar, P. J., Hubbs, A. F., Castranova, V., & Boegehold, M. A. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8413 · Cited by 267 · see citing works
“Soluble metals have been shown to drive many of the pulmonary effects of ROFA (Dreher et al. 1997; Kodavanti et al. 1998; Rice et al. 2001).”
BackgroundMechanisms of morbidity and mortality from exposure to ambient air particles.
Godleski, J. J., Verrier, R. L., Koutrakis, P., Catalano, P. J., Coull, B. A., Reinisch, U., Lovett, E. G., Lawrence, J. E., Murthy, G. G. K., Wolfson, J. M., et al. (2000) · PubMed · Cited by 252 · see citing works
Brown, D. M., Stone, V., Findlay, P., MacNee, W., & Donaldson, K. (2000) · Occupational and Environmental Medicine · doi:10.1136/oem.57.10.685 · Cited by 247 · see citing works
Simulating the evolution of soot mixing state with a particle‐resolved aerosol model
Riemer, N., West, M., Zaveri, R. A., & Easter, R. C. (2009) · Journal of Geophysical Research Atmospheres · doi:10.1029/2008jd011073 · Cited by 243 · see citing works
Chemical analysis of World Trade Center fine particulate matter for use in toxicologic assessment.
McGee, J. K., Chen, L., Cohen, M. D., Chee, G. R., Prophete, C., Haykal-Coates, N., Wasson, S. J., Conner, T. L., Costa, D. L., & Gavett, S. H. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.5930 · Cited by 233 · see citing works
Quay, J., Reed, W., Samet, J. M., & Devlin, R. B. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.1.3132 · Cited by 230 · see citing works
“ROFA, a byproduct of oil combustion, is an important emission source of metal containing particulates, characterized by a high vanadium content in addition to the presence of nickel and iron (12, 13).”
InfluentialPulmonary Responses to Welding Fumes: Role of Metal Constituents
Antonini, J. M., Taylor, M. D., Zimmer, A. T., & Roberts, J. R. (2004) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390490266909 · Cited by 221 · see citing works
“…in that studies of other environmental and occupational metal-containing particulates, such as residual oil fly ash and urban air particulates, have attributed many of their pneumotoxic effects to the presence of soluble metals (Dreher et al., 1997; Kodavanti et al., 1998; Lewis et al., 2003).”
BackgroundGualtieri, M., Øvrevik, J., Holme, J. A., Perrone, M., Bolzacchini, E., Schwarze, P. E., & Camatini, M. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.09.013 · Cited by 219 · see citing works
“PM exposure of humans and animals has been shown to lead to inflammatory cell recruitment and pro-inflammatory cytokines release (Dreher et al., 1997; Martin et al., 2007; Cho et al., 2007; Wegesser and Last, 2008).”
BackgroundMicrofluidics for Biomedical Analysis
Yang, Y. S., Chen, Y., Tang, H., Zong, N., & Jiang, X. (2019) · Small Methods · doi:10.1002/smtd.201900451 · Cited by 218 · see citing works
Shi, T., Schins, R. P. F., Knaapen, A. M., Kuhlbusch, T. A. J., Pitz, M., Heinrich, J., & Borm, P. J. A. (2003) · Journal of Environmental Monitoring · doi:10.1039/b303928p · Cited by 209 · see citing works
Ghio, A. J. (1999) · Inhalation Toxicology · doi:10.1080/089583799197258 · Cited by 205 · see citing works
RAVINDRA, R., Mittal, A. K., & Grieken, R. V. (2001) · Reviews on Environmental Health · doi:10.1515/reveh.2001.16.3.169 · Cited by 198 · see citing works
Biologic effects of oil fly ash.
Ghio, A. J., Silbajoris, R. A., Carson, J. L., & Samet, J. M. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s1189 · Cited by 198 · see citing works
“This is almost always neutrophilic, but occasional eosinophilic infiltration into the lower respiratory tract has been noted (27).”
BackgroundEpisodes of High Coarse Particle Concentrations Are Not Associated with Increased Mortality
Schwartz, J., Norris, G. A., Larson, T. V., Sheppard, L. A., Claiborne, C., & Koenig, J. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107339 · Cited by 197 · see citing works
The role of outdoor air pollution and climatic changes on the rising trends in respiratory allergy
D'AMATO, G., LICCARDI, G., D'AMATO, M., & CAZZOLA, M. (2001) · Respiratory Medicine · doi:10.1053/rmed.2001.1112 · Cited by 191 · see citing works
Kodavanti, U. P., Schladweiler, M. C., Ledbetter, A. D., Watkinson, W. P., Campen, M. J., Winsett, D. W., Richards, J. R., Crissman, K. M., Hatch, G. E., & Costa, D. L. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.8899 · Cited by 191 · see citing works
Biologic effects induced in vitro by PM10 from three different zones of Mexico City.
Alfaro‐Moreno, E., Martínez, L., García-Cuellar, C. M., Bonner, J. C., Murray, J. C., Rosas, I., Rosales, S. P. D. L., & Osornio-Vargas, Á. R. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110715 · Cited by 191 · see citing works
“The relative importance of metals and endotoxin in mediating the toxic effects of these particles is currently unknown (9,10,23,28).”
BackgroundDye, J. A., Lehmann, J. R., McGee, J. K., Winsett, D. W., Ledbetter, A. D., Everitt, J. I., Ghio, A., & Costa, D. L. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s3395 · Cited by 189 · see citing works
“To date, most studies exploring the role of metals in PM toxicity have used readily soluble metals (typically SO4) and have attributed toxicity to the soluble metals apart from anionic speciation (23,24).”
BackgroundResultKodavanti, U. P., Hauser, R. B., Christiani, D. C., Meng, Z. H., McGee, J., Ledbetter, A., Richards, J., & Costa, D. L. (1998) · Toxicological Sciences · doi:10.1006/toxs.1998.2460 · Cited by 189 · see citing works
Sholkovitz, E. R., Sedwick, P. N., & Church, T. M. (2009) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2009.04.029 · Cited by 188 · see citing works
Kim, J., Mukherjee, S., Ngo, L., & Christiani, D. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6827 · Cited by 194 · see citing works
“Urinary 8-OHdG was determined using a competitive enzymelinked immunosorbent assay (Japan Institute for the Control of Aging, Fukuroi, Shizuoka, Japan; Erhola et al. 1997; Leinonen et al. 1997).”
Hetland, R. B., Cassee, F. R., Låg, M., Refsnes, M., Dybing, E., & Schwarze, P. E. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-4 · Cited by 181 · see citing works
“Transition metals in the soluble fraction of residual oil fly ash (ROFA) were found to be responsible for increased release of inflammatory cytokines [17,18].”
BackgroundEffects of aqueous extracts of PM10filters from the Utah Valley on human airway epithelial cells
Frampton, M. W., Ghio, A. J., Samet, J. M., Carson, J. L., Carter, J. D., & Devlin, R. B. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.5.l960 · Cited by 181 · see citing works
Kadiiska, M. B., Mason, R. P., Dreher, K. L., Costa, D. L., & Ghio, A. J. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970049r · Cited by 174 · see citing works
Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation
Nurkiewicz, T. R., Porter, D. W., Barger, M. W., Castranova, V., & Boegehold, M. A. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7001 · Cited by 172 · see citing works
“Toxic pulmonary responses to ROFA have been linked to the high concentrations of soluble metals associated with these particles (Antonini et al. 2002; Dreher et al. 1997).”
BackgroundBillet, S., Garçon, G., Dagher, Z., Verdin, A., Ledoux, F., Cazier, F., Courcot, D., Aboukaı̈s, A., & Shirali, P. (2007) · Environmental Research · doi:10.1016/j.envres.2007.03.001 · Cited by 170 · see citing works
“Accordingly, transition metals, VOC and PAH are often associated with PM, either through adherence to the core particle or as an integral component of the particle (Dreher et al., 1997; Monn and Becker, 1999; Nel et al., 2001).”
BackgroundBorm, P. J. A. (1997) · The Annals of Occupational Hygiene · doi:10.1016/s0003-4878(97)00026-4 · Cited by 170 · see citing works
Particle characteristics responsible for effects on human lung epithelial cells.
Aust, A. E., Ball, J. C., Hu, A. A., Lighty, J. S., Smith, K. R., Straccia, A. M., Veranth, J. M., & Young, W. C. (2002) · PubMed · Cited by 170 · see citing works
Clarke, R. W., Coull, B. A., Reinisch, U., Catalano, P. J., Killingsworth, C. R., Koutrakis, P., Kavouras, I. G., Murthy, G. G. K., Lawrence, J. E., Lovett, E. G., et al. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.001081179 · Cited by 168 · see citing works
“Previous studies investigating relationships between constituents or surrogates of ambient air pollution and biologic responses have mainly focused on combustion-related trace metals (V, Ni, Cu) that are associated with airborne particulates (14,15).”
BackgroundDagher, Z., Garçon, G., Billet, S., Gosset, P., Ledoux, F., Courcot, D., Aboukaı̈s, A., & Shirali, P. (2006) · Toxicology · doi:10.1016/j.tox.2006.04.038 · Cited by 168 · see citing works
“Components such as transition metals, VOC, and PAH are known to be associated with PM, either through adherence to the core particle or as an integral component of the particle (Dreher et al., 1997; Monn and Becker, 1999; Nel et al., 2001).”
BackgroundLinak, W. P., Miller, C. A., & WENDT, J. O. L. (2000) · Journal of the Air & Waste Management Association · doi:10.1080/10473289.2000.10464171 · Cited by 167 · see citing works
Pozzi, R., Berardis, B. D., Paoletti, L., & Guastadisegni, C. (2003) · Toxicology · doi:10.1016/s0300-483x(02)00545-0 · Cited by 166 · see citing works
The Role of Toll-like Receptor 4 in Environmental Airway Injury in Mice
Hollingsworth, J. W., Cook, D. N., Brass, D. M., Walker, J. K. L., Morgan, D. L., Foster, W. M., & Schwartz, D. A. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200311-1499oc · Cited by 166 · see citing works
“This finding suggests that components of ROFA, such as heavy metals (20, 46), play a more prominent role in the pulmonary response to acute ROFA exposure.”
BackgroundThe Role of Fossil Fuel Combustion Metals in PM2.5 Air Pollution Health Associations
Maciejczyk, P., Chen, L., & Thurston, G. D. (2021) · Atmosphere · doi:10.3390/atmos12091086 · Cited by 170 · see citing works
“Indeed, decades ago, Dreher and colleagues [131] proposed such a causal role by sulfates and soluble transition metals (V, Fe, Ni) on the basis of studies in which rats were exposed by intratracheal instillation to oil combustion fly ash.”
BackgroundPollitt, K. J. G., Harrison, R. M., Evans, T., Baker, T., Dunster, C., Mudway, I., & Kelly, F. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021961 · Cited by 163 · see citing works
“Compositional details of the residual oil fly ash [18–23] and M120 [24,25] control particles have been published elsewhere.”
BackgroundHealth effects of concentrated ambient air particulate matter (CAPs) and its components
Lippmann, M., & Chen, L. (2009) · Critical Reviews in Toxicology · doi:10.3109/10408440903300080 · Cited by 160 · see citing works
Pardo, M., Qiu, X., Zimmermann, R., & Rudich, Y. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00007 · Cited by 162 · see citing works
Gavett, S. H., Madison, S. L., Dreher, K. L., Winsett, D. W., McGee, J. K., & Costa, D. L. (1997) · Environmental Research · doi:10.1006/enrs.1997.3732 · Cited by 156 · see citing works
Pulmonary Toxicity of an Atmospheric Particulate Sample Is Due to the Soluble Fraction
Adamson, I. Y. R., Prieditis, H., & Vincent, R. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8658 · Cited by 154 · see citing works
Pivotal Roles of Metal Oxides in the Formation of Environmentally Persistent Free Radicals
Yang, L., Liu, G., Zheng, M., Jin, R., Zhao, Y., Wu, X., & Xu, Y. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b03583 · Cited by 152 · see citing works
Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro
McNeilly, J., Heal, M. R., Beverland, I. J., Howe, A. M., Gibson, M. D., Hibbs, L. R., MacNee, W., & Donaldson, K. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.11.021 · Cited by 149 · see citing works
“…have demonstrated that the pulmonary toxicity of complex metal-containing particulates can be associated with the soluble forms of transition metals and the dose (Adamson et al., 2000; Carter et al., 1997; Dreher et al., 1997; Hetland et al., 2001; Kennedy et al., 1998; Kodavanti et al., 1997).”
BackgroundInfluentialCharrier, J. G., & Anastasio, C. (2010) · Atmospheric Environment · doi:10.1016/j.atmosenv.2010.12.021 · Cited by 148 · see citing works
“…correlatedwith the soluble transition metal (TM) content of PM, which has also been correlated with particle-mediated cardiopulmonary toxicity (Carter et al., 1997; Costa and Dreher, 1997; Dreher et al., 1997; Gavett et al., 1997; DiStefano et al., 2009; Vidrio et al., 2009; Zhong et al., 2010).”
BackgroundPulmonary Nanoparticle Exposure Disrupts Systemic Microvascular Nitric Oxide Signaling
Nurkiewicz, T. R., Porter, D. W., Hubbs, A. F., Stone, S., Chen, B. T., Frazer, D. G., Boegehold, M. A., & Castranova, V. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp051 · Cited by 147 · see citing works
“one technique, particle or emission condition to affect smooth muscle NO sensitivity, while another does not, is high because numerous biological mechanisms have been identified and/or advanced to help explain how a particle of pulmonary origin can influence a systemic tissue (Brook et al., 2004; Donaldson et al., 200…”
BackgroundSchleicher, N., Norra, S., Chai, F., Chen, Y., Wang, S., Cen, K., Yu, Y., & Stüben, D. (2011) · Atmospheric Environment · doi:10.1016/j.atmosenv.2011.08.067 · Cited by 146 · see citing works
Rates of Hydroxyl Radical Production from Transition Metals and Quinones in a Surrogate Lung Fluid
Charrier, J. G., & Anastasio, C. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b01606 · Cited by 145 · see citing works
Characterization of Aerosols Containing Zn, Pb, and Cl from an Industrial Region of Mexico City
Moffet, R. C., Desyaterik, Y., Hopkins, R. J., Tivanski, A. V., Gilles, M. K., Wang, Y., Shutthanandan, V. S., Molina, L. T., Gonzalez-Abraham, R., Johnson, K. S., et al. (2008) · Environmental Science & Technology · doi:10.1021/es7030483 · Cited by 145 · see citing works
Generation of hydroxyl radicals from dissolved transition metals in surrogate lung fluid solutions
Vidrio, E., Jung, H., & Anastasio, C. (2008) · Atmospheric Environment · doi:10.1016/j.atmosenv.2008.01.004 · Cited by 142 · see citing works
“PM contains trace amounts of a wide variety of transition metals (Dreher et al., 1997; Song et al., 2003; Valavanidis et al., 2005a, b, 2006).”
BackgroundInfluentialANALYSIS OF AIR POLLUTION PARTICULATE-MEDIATED OXIDANT STRESS IN ALVEOLAR MACROPHAGES
Imrich, C.-A. W. G. A. (1998) · Journal of Toxicology and Environmental Health · doi:10.1080/009841098158683 · Cited by 141 · see citing works
Veronesi, B., Oortgiesen, M., Carter, J. D., & Devlin, R. B. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8567 · Cited by 140 · see citing works
Gwynn, R. C., Burnett, R. T., & Thurston, G. D. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108125 · Cited by 139 · see citing works
Campen, M. J. (2001) · Toxicological Sciences · doi:10.1093/toxsci/64.2.243 · Cited by 139 · see citing works
“Several studies have been conducted that demonstrate the in vivo and in vitro toxicity of various metals, including Ni, V, Fe, and Zn (Campen et al., manuscript in preparation; Dreher et al., 1997; Dye et al., 1999; Kadiiska et al., 1997; Kodavanti et al., 1997).”
BackgroundCharrier, J. G., Richards-Henderson, N. K., Bein, K. J., McFall, A. S., Wexler, A. S., & Anastasio, C. (2015) · Atmospheric chemistry and physics · doi:10.5194/acp-15-2327-2015 · Cited by 138 · see citing works
“Traffic and residual oil fly ash are two sources commonly associated with adverse effects (Hoffmann et al., 2007; Peters et al., 2004; Dreher et al., 1997), possibly due to the ability of transition metals in the PM to cause oxidative stress (Gasser et al., 2009; Antonini et al., 2004; Aust et al.,…”
BackgroundWhat Do Epidemiologic Findings Tell Us about Health Effects of Environmental Aerosols?
Pope, C. A. (2000) · Journal of Aerosol Medicine · doi:10.1089/jam.2000.13.335 · Cited by 138 · see citing works
Lei, Y.-C., Chan, C., Wang, P.-Y., Lee, C.-T., & Cheng, T. (2003) · Environmental Research · doi:10.1016/s0013-9351(03)00136-1 · Cited by 135 · see citing works
International journal of the environment
(1977) · Ceramurgia International · doi:10.1016/0390-5519(77)90077-1 · Cited by 132 · see citing works
Garçon, G., Dagher, Z., Zerimech, F., Ledoux, F., Courcot, D., Aboukaı̈s, A., Puskaric, E., & Shirali, P. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.09.012 · Cited by 133 · see citing works
van Maanen, P. J. A. B. J. M. S. (1999) · Inhalation Toxicology · doi:10.1080/089583799196628 · Cited by 133 · see citing works
Kiruri, L. W., Khachatryan, L., Dellinger, B., & Lomnicki, S. M. (2014) · Environmental Science & Technology · doi:10.1021/es404013g · Cited by 131 · see citing works
Clouter, A. (2001) · Toxicological Sciences · doi:10.1093/toxsci/63.1.90 · Cited by 131 · see citing works
“, 1996), and residual oil fly ash (Dreher et al., 1997) are considered to generate free radicals via released transition metals, principally iron, and thereby cause lung inflammation.”
BackgroundUlrich, M. M. W., Alink, G. M., Kumarathasan, P., Vincent, R., Boere, A. J. F., & Cassee, F. R. (2002) · Journal of Toxicology and Environmental Health · doi:10.1080/00984100290071676 · Cited by 129 · see citing works
“Mechanistic studies using the technique of intratracheal instillation of PM fractions from various sites and composition have been shown to cause pulmonary cytotoxicity, inflammation, and production of reactive oxygen species (Hatch et al., 1985; Ghio et al., 1992; Ghio & Hatch, 1993; Adamson & Bowden, 1982; Adamson e…”
MethodSowlat, M. H., Hasheminassab, S., & Sioutas, C. (2016) · Atmospheric chemistry and physics · doi:10.5194/acp-16-4849-2016 · Cited by 130 · see citing works
COMPARATIVE PULMONARY TOXICITY OF VARIOUS SOLUBLE METALS FOUND IN URBAN PARTICULATE DUSTS
Prieditis, H., & Adamson, I. Y. R. (2002) · Experimental Lung Research · doi:10.1080/01902140290096782 · Cited by 125 · see citing works
Ambient Urban Baltimore Particulate-induced Airway Hyperresponsiveness and Inflammation in Mice
Walters, D. M., Breysse, P. N., & Wills-Karp, M. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.8.2007121 · Cited by 125 · see citing works
Seasonal trends, chemical speciation and source apportionment of fine PM in Tehran
Arhami, M., Hosseini, V., Shahne, M. Z., Bigdeli, M., Lai, A. M., & Schauer, J. J. (2016) · Atmospheric Environment · doi:10.1016/j.atmosenv.2016.12.046 · Cited by 123 · see citing works
MacNee, W., & Donaldson, K. (1999) · Air Pollution and Health · doi:10.1016/b978-012352335-8/50105-8 · Cited by 122 · see citing works
Wellenius, G. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/66.2.327 · Cited by 120 · see citing works
“ROFA particles are rich in transition metals, many of which are soluble and have the ability to reach the heart (Dreher et al., 1997).”
BackgroundChemical speciation of trace metals emitted from Indonesian peat fires for health risk assessment
Betha, R., Pradani, M., Lestari, P., Joshi, U. M., Reid, J. S., & Balasubramanian, R. (2012) · Atmospheric Research · doi:10.1016/j.atmosres.2012.05.024 · Cited by 119 · see citing works
“Among the chemical components in aerosols, trace metals have attracted great attention due to their potential health effects (Adamson et al., 2000; Betha and Balasubramanian, 2011; Dreher et al., 1997; Dye et al., 2001; Espinosa et al., 2002; Ghio and Devlin, 2001).”
BackgroundNanotechnology and Nanotoxicology
Curtis, J. A., Greenberg, M., Kester, J. E., Phillips, S., & Krieger, G. R. (2006) · Toxicological Reviews · doi:10.2165/00139709-200625040-00005 · Cited by 124 · see citing works
Watkinson, W. P., Campen, M. J., Nolan, J. P., & Costa, D. L. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s4539 · Cited by 118 · see citing works
Wang, D., Pakbin, P., Shafer, M. M., Antkiewicz, D. S., Schauer, J. J., & Sioutas, C. (2013) · Atmospheric Environment · doi:10.1016/j.atmosenv.2013.05.031 · Cited by 118 · see citing works
“Various studies have reported toxicity responses of both soluble (Dreher et al., 1997; Li et al., 2008) and insoluble species (Jalava et al.”
BackgroundCombustion-Derived Ultrafine Particles Transport Organic Toxicants to Target Respiratory Cells
Penn, A. L., Murphy, G., Barker, S. A., Henk, W. G., & Penn, L. S. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7661 · Cited by 118 · see citing works
“Injury to airway cells and alterations in cytokine gene expression in response to ROFA exposure have been reported (Dreher et al. 1997; Dye et al. 1999; Samet et al. 2002).”
BackgroundKaranasiou, A., Sitaras, I. E., Siskos, P. A., & Eleftheriadis, K. (2007) · Atmospheric Environment · doi:10.1016/j.atmosenv.2006.11.006 · Cited by 115 · see citing works
- Authors
- Kevin L. Dreher, R. H. J.
- Venue
- Journal of Toxicology and Environmental Health
- Publisher
- Informa UK Limited
- Published
- 1997-02
- Volume
- 50
- Issue
- 3
- Pages
- 285-305
- ISSN
- 0098-4108 (ISSN-L)
- OpenAlex
- W2169046198
- Cited by
- 486
- References
- 32
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 17 · 2014: 9 · 2013: 17 · 2012: 13
- FWCI
- 34.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Toxicology and Environmental Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Earth and Planetary Sciences › Geochemistry and Petrology › Coal and Its By-products
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- residual oil fly ash, acute lung injury, iron, nickel, vanadium, pulmonary toxicity, bronchoalveolar lavage fluid, airway inflammation, metal interactions, pH effect, particulate matter pollution
- MeSH terms
- Acute Disease, Air Pollutants, Animals, Carbon, Chemistry, Physical, Fuel Oils, Inflammation, Lung Diseases, Male, Metals, Particle Size, Solubility, Sulfates, Rats, Sprague-Dawley, Rats, Chemical Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
