The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013
Open accessAbstract
Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: In this review, we summarize data obtained since 2007, focusing on a) findings from human and animal studies, b) the effects of BPA on a variety of reproductive end points, and c) mechanisms of BPA action. Methods: We reviewed the literature published from 2007 to 2013 using a PubMed search based on keywords related to BPA and male and female reproduction. Discussion: Because BPA has been reported to affect the onset of meiosis in both animal and in vitro models, interfere with germ cell nest breakdown in animal models, accelerate follicle transition in several animal species, alter steroidogenesis in multiple animal models and women, and reduce oocyte quality in animal models and women undergoing in vitro fertilization (IVF), we consider it an ovarian toxicant. In addition, strong evidence suggests that BPA is a uterine toxicant because it impaired uterine endometrial proliferation, decreased uterine receptivity, and increased implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm these associations. Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, the placenta, and pubertal development. Conclusion: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, we conclude that BPA is a reproductive toxicant. Citation: Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. 2014. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect 122:775–786; http://dx.doi.org/10.1289/ehp.1307728
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“BPA is thought to be an endocrine disruptor that acts as an estrogen mimetic [ 128–131 ], thus research has focused largely on its effects in reproductive tissues.”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [131]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Calamita, E., Schmid, M., Kunz, M., Ndebele-Murisa, M. R., Magadza, C. H. D., Nyambe, I., & Wehrli, B. (2019) · Figshare · doi:10.26181/6153922fe919c · Cited by 4,239
Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A
Vandenberg, L. N., Chahoud, I., Heindel, J. J., Padmanabhan, V., Paumgartten, F. J. R., & Schönfelder, G. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901716 · Cited by 1,275
Self-citationIn vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Saal, F. S. V., Akingbemi, B. T., Belcher, S. M., Birnbaum, L. S., Crain, D. A., Eriksen, M., Farabollini, F., Guillette, L. J., Hauser, R. B., Heindel, J. J., et al. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.005 · Cited by 728
Self-citationBisphenol A Exposure Causes Meiotic Aneuploidy in the Female Mouse
Hunt, P. A., Koehler, K. E., Susiarjo, M., Hodges, C. A., Ilagan, A., Voigt, R. C., Thomas, S., Thomas, B. F., & Hassold, T. J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00189-1 · Cited by 636
Self-citationPrenatal Phenol and Phthalate Exposures and Birth Outcomes
Wolff, M. S., Engel, S. M., Berkowitz, G. S., Ye, X., Silva, M. J., Zhu, C., Wetmur, J. G., & Calafat, A. M. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11007 · Cited by 580
Bisphenol A Exposure In Utero Disrupts Early Oogenesis in the Mouse
Susiarjo, M., Hassold, T. J., Freeman, E., & Hunt, P. A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030005 · Cited by 477
Self-citationExposure to Phthalates and Phenols during Pregnancy and Offspring Size at Birth
Philippat, C., Mortamais, M., Chevrier, C., Petit, C., Calafat, A. M., Ye, X., Silva, M. J., Brambilla, C., Pin, I., Charles, M.-A. A., et al. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1103634 · Cited by 452
Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A
Vandenberg, L. N., Chahoud, I., Heindel, J. J., Padmanabhan, V., Paumgartten, F. J. R., & Schönfelder, G. (2012) · Ciência & Saúde Coletiva · doi:10.1590/s1413-81232012000200015 · Cited by 442
Self-citationMeeker, J. D., Ehrlich, S., Toth, T. L., Wright, D. L., Calafat, A. M., Trisini, A. T., Ye, X., & Hauser, R. B. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.07.005 · Cited by 413
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Self-citationAtmospheric microplastics: A review on current status and perspectives
Zhang, Y., Kang, S., Allen, S., Allen, D., Gao, T., & Sillanpää, M. E. T. (2020) · Earth-Science Reviews · doi:10.1016/j.earscirev.2020.103118 · Cited by 1,457
Eladak, S., Grisin, T., Moison, D., Guerquin, M.-J., N’Tumba-Byn, T., Pozzi-Gaudin, S., Benachi, A., Livera, G., Rouiller, V., & Habert, R. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.11.005 · Cited by 713
The potential effects of microplastics on human health: What is known and what is unknown
Blackburn, K. J., & Green, D. (2021) · AMBIO · doi:10.1007/s13280-021-01589-9 · Cited by 541
Environmental pollutants and child health—A review of recent concerns
Vrijheid, M., Casas, M., Gascón, M., Valvi, D., & Nieuwenhuijsen, M. J. (2016) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2016.05.001 · Cited by 402
Metadata
- Authors
- Peretz, J., Vrooman, L., Ricke, W. A., Hunt, P. A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H. S., Swan, S. H., VandeVoort, C. A., & Flaws, J. A.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Washington State University (US)
- University of Wisconsin–Madison (US)
- Cincinnati Children's Hospital Medical Center (US)
- Harvard University (US)
- University of Michigan (US)
- Yale University (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of California, Davis (US)
- Corresponding author
- Flaws, Jodi A.
- ORCID
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-06-04
- Volume
- 122
- Issue
- 8
- Pages
- 775-786
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC4123031
- OpenAlex
- W2020338693
- Cited by
- 555
- References
- 140
- Citations by year
- 2026: 28 · 2025: 32 · 2024: 34 · 2023: 51 · 2022: 38 · 2021: 46 · 2020: 51 · 2019: 43 · 2018: 56 · 2017: 43 · 2016: 68 · 2015: 56 · 2014: 7
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 1304 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion, public-domain)
- Funders
- National Institutes of Health (P51OD011107)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572)
- National Institute of Environmental Health Sciences (R01ES16541, RC2ES18764, R01ES009718, R01ES016770, R01ES9718, R01ES016541, R01ES019178, P20ES018163, R01ES16770, P01ES022844, R01ES017005, R01ES013527, R01 ES13527, P01ES022848, R01ES17005, RC2ES018764, P30ES023515, P30ES017885)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- bisphenol A, reproductive toxicity, endocrine disruptors, female reproduction, male reproduction, ovarian toxicity, uterine toxicity, testicular toxicity, meiosis, steroidogenesis, oocyte quality, in vitro fertilization, endometrial proliferation, endometrial receptivity, implantation failure, birth outcomes, hyperandrogenism, sexual dysfunction, mechanism of action
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Female, Humans, Male, Embryo Implantation, Phenols, Pregnancy, Reproduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
