Cited by 555Effects and risks of endocrine disrupting chemicalsReproductive Biology and FertilityEstrogen and related hormone effects

The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.

Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

Open access

Peretz, Jackye, Vrooman, Lisa, Ricke, William A., Hunt, Patricia A., Ehrlich, Shelley, Hauser, Russ, Padmanabhan, Vasantha, Taylor, Hugh S., Swan, Shanna H., VandeVoort, Catherine A., Flaws, Jodi A.·2014·Environmental Health Perspectives

DOI 10.1289/ehp.1307728PMC PMC4123031

Open this paper in CoChat — free account

Abstract

Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: In this review, we summarize data obtained since 2007, focusing on a) findings from human and animal studies, b) the effects of BPA on a variety of reproductive end points, and c) mechanisms of BPA action. Methods: We reviewed the literature published from 2007 to 2013 using a PubMed search based on keywords related to BPA and male and female reproduction. Discussion: Because BPA has been reported to affect the onset of meiosis in both animal and in vitro models, interfere with germ cell nest breakdown in animal models, accelerate follicle transition in several animal species, alter steroidogenesis in multiple animal models and women, and reduce oocyte quality in animal models and women undergoing in vitro fertilization (IVF), we consider it an ovarian toxicant. In addition, strong evidence suggests that BPA is a uterine toxicant because it impaired uterine endometrial proliferation, decreased uterine receptivity, and increased implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm these associations. Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, the placenta, and pubertal development. Conclusion: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, we conclude that BPA is a reproductive toxicant. Citation: Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. 2014. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect 122:775–786; http://dx.doi.org/10.1289/ehp.1307728

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1289/ehp.1307728

Cites

140 of 140 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation
Calamita, E., Schmid, M., Kunz, M., Ndebele-Murisa, M. R., Magadza, C. H. D., Nyambe, I., & Wehrli, B. (2019) · Figshare · doi:10.26181/6153922fe919c · Cited by 4,239
Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A
Vandenberg, L. N., Chahoud, I., Heindel, J. J., Padmanabhan, V., Paumgartten, F. J. R., & Schönfelder, G. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901716 · Cited by 1,275
Self-citation
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
Saal, F. S. V., Akingbemi, B. T., Belcher, S. M., Birnbaum, L. S., Crain, D. A., Eriksen, M., Farabollini, F., Guillette, L. J., Hauser, R. B., Heindel, J. J., et al. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.005 · Cited by 728
Self-citation
Bisphenol A Exposure Causes Meiotic Aneuploidy in the Female Mouse
Hunt, P. A., Koehler, K. E., Susiarjo, M., Hodges, C. A., Ilagan, A., Voigt, R. C., Thomas, S., Thomas, B. F., & Hassold, T. J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00189-1 · Cited by 636
Self-citation
Prenatal Phenol and Phthalate Exposures and Birth Outcomes
Wolff, M. S., Engel, S. M., Berkowitz, G. S., Ye, X., Silva, M. J., Zhu, C., Wetmur, J. G., & Calafat, A. M. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11007 · Cited by 580
Bisphenol A Exposure In Utero Disrupts Early Oogenesis in the Mouse
Susiarjo, M., Hassold, T. J., Freeman, E., & Hunt, P. A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030005 · Cited by 477
Self-citation
Exposure to Phthalates and Phenols during Pregnancy and Offspring Size at Birth
Philippat, C., Mortamais, M., Chevrier, C., Petit, C., Calafat, A. M., Ye, X., Silva, M. J., Brambilla, C., Pin, I., Charles, M.-A. A., et al. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1103634 · Cited by 452
Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A
Vandenberg, L. N., Chahoud, I., Heindel, J. J., Padmanabhan, V., Paumgartten, F. J. R., & Schönfelder, G. (2012) · Ciência & Saúde Coletiva · doi:10.1590/s1413-81232012000200015 · Cited by 442
Self-citation
Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic
Meeker, J. D., Ehrlich, S., Toth, T. L., Wright, D. L., Calafat, A. M., Trisini, A. T., Ye, X., & Hauser, R. B. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.07.005 · Cited by 413
Self-citation

Flagged first, then by citations

Show all 140 references

Sorted by citations

EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Self-citation
Atmospheric microplastics: A review on current status and perspectives
Zhang, Y., Kang, S., Allen, S., Allen, D., Gao, T., & Sillanpää, M. E. T. (2020) · Earth-Science Reviews · doi:10.1016/j.earscirev.2020.103118 · Cited by 1,457
A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound
Eladak, S., Grisin, T., Moison, D., Guerquin, M.-J., N’Tumba-Byn, T., Pozzi-Gaudin, S., Benachi, A., Livera, G., Rouiller, V., & Habert, R. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.11.005 · Cited by 713
The potential effects of microplastics on human health: What is known and what is unknown
Blackburn, K. J., & Green, D. (2021) · AMBIO · doi:10.1007/s13280-021-01589-9 · Cited by 541
Environmental pollutants and child health—A review of recent concerns
Vrijheid, M., Casas, M., Gascón, M., Valvi, D., & Nieuwenhuijsen, M. J. (2016) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2016.05.001 · Cited by 402
Effects of bisphenol A and its analogs on reproductive health: A mini review
Siracusa, J. S., Yin, L., Measel, E., Liang, S., & Yu, X. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.06.005 · Cited by 343
Exposure to endocrine disruptors during adulthood: consequences for female fertility
Rattan, S., Zhou, C., Chiang, C., Mahalingam, S., Brehm, E., & Flaws, J. A. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0023 · Cited by 339
Self-citation
Membrane-Confined Iron Oxychloride Nanocatalysts for Highly Efficient Heterogeneous Fenton Water Treatment
Zhang, S., Hedtke, T., Zhu, Q., Sun, M., Weon, S., Zhao, Y., Stavitski, E., Elimelech, M., & Kim, J. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c01391 · Cited by 318
Fate of Bisphenol A in Terrestrial and Aquatic Environments
Im, J., & Löffler, F. E. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b00877 · Cited by 308
Neuro-toxic and Reproductive Effects of BPA
Santoro, A., Chianese, R., Troisi, J., Richards, S. M., Nori, S. L., Fasano, S., Guida, M., Plunk, E. C., Viggiano, A., Pierantoni, R., et al. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190726112101 · Cited by 288
Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring
Mustieles, V., D’Cruz, S. C., Couderq, S., Rodríguez‐Carrillo, A., Fini, J., Hofer, T., Steffensen, I., Dirven, H. A. A. M., Barouki, R., Olea, N., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.105811 · Cited by 282
Evidence for bisphenol A-induced female infertility: a review (2007–2016)
Ziv‐Gal, A., & Flaws, J. A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.06.027 · Cited by 247
Self-citation
Update on the Health Effects of Bisphenol A: Overwhelming Evidence of Harm
Saal, F. S. V., & Vandenberg, L. N. (2020) · Endocrinology · doi:10.1210/endocr/bqaa171 · Cited by 262
Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?
Xin, F., Susiarjo, M., & Bartolomei, M. S. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.05.008 · Cited by 253
Developmental Programming, a Pathway to Disease
Padmanabhan, V., Cardoso, R. C., & Puttabyatappa, M. (2016) · Endocrinology · doi:10.1210/en.2016-1003 · Cited by 244
Self-citation
Effects of Endocrine-Disrupting Chemicals on the Ovary1
Patel, S. A., Zhou, C., Rattan, S., & Flaws, J. A. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.130336 · Cited by 225
Self-citation
Recent Fast Food Consumption and Bisphenol A and Phthalates Exposures among the U.S. Population in NHANES, 2003–2010
Zota, A. R., Phillips, C. A., & Mitro, S. D. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1510803 · Cited by 216
Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women
Aker, A. M., Watkins, D. J., Johns, L. E., Ferguson, K. K., Soldin, O. P., Toro, L. V. A. D., Alshawabkeh, A. N., Cordero, J. F., & Meeker, J. D. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.002 · Cited by 201
Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union
Hunt, P. A., Sathyanarayana, S., Fowler, P., & Trasande, L. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2873 · Cited by 205
Self-citation
A Narrative Review on the Pathophysiology of Preeclampsia
Torres‐Torres, J., y Sosa, S. E., Martinez-Portilla, R. J., Borboa-Olivares, H. J., Estrada‐Gutiérrez, G., Acevedo‐Gallegos, S., Ruiz-Ramirez, E., Velasco-Espin, M., Cerda‐Flores, P., Ramirez-Gonzalez, A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147569 · Cited by 213
Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism
Tran, N. Q. V., & Miyake, K. (2017) · International Journal of Genomics · doi:10.1155/2017/7526592 · Cited by 189
The developmental origins of the mammalian ovarian reserve
Grive, K. J., & Freiman, R. N. (2015) · Development · doi:10.1242/dev.125211 · Cited by 170
Bisphenol-A Affects Male Fertility via Fertility-related Proteins in Spermatozoa
Rahman, M. S., Kwon, W., Lee, J.-S., Yoon, S., Ryu, B., & Pang, M. (2015) · Scientific Reports · doi:10.1038/srep09169 · Cited by 172
Racial/Ethnic Disparities in Environmental Endocrine Disrupting Chemicals and Women’s Reproductive Health Outcomes: Epidemiological Examples Across the Life Course
James-Todd, T. M., Chiu, Y., & Zota, A. R. (2016) · Current Epidemiology Reports · doi:10.1007/s40471-016-0073-9 · Cited by 177
Endocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPA
Vandenberg, L. N., Hunt, P. A., & Gore, A. C. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0173-y · Cited by 171
Self-citation
Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period
Green, M. P., Harvey, A. J., Finger, B. J., & Tarulli, G. A. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110694 · Cited by 168
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?
Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167
Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood
Vafeiadi, M., Roumeliotaki, T., Myridakis, A., Chalkiadaki, G., Fthenou, E., Dermitzaki, E., Karachaliou, M., Sarri, K. O., Vassilaki, M. E., Stephanou, E. G., et al. (2016) · Environmental Research · doi:10.1016/j.envres.2016.01.017 · Cited by 173
Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs)
Palioura, E., & Diamanti-Kandarakis, E. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9326-7 · Cited by 161
Gestational Exposure to Bisphenol A Affects the Function and Proteome Profile of F1 Spermatozoa in Adult Mice
Rahman, M. S., Kwon, W., Karmakar, P. C., Yoon, S., Ryu, B., & Pang, M. (2016) · Environmental Health Perspectives · doi:10.1289/ehp378 · Cited by 153
Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure
Saal, F. S. V., & Welshons, W. V. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.09.028 · Cited by 160
Serum Testosterone Concentrations and Urinary Bisphenol A, Benzophenone-3, Triclosan, and Paraben Levels in Male and Female Children and Adolescents: NHANES 2011–2012
Scinicariello, F., & Buser, M. C. (2016) · Environmental Health Perspectives · doi:10.1289/ehp150 · Cited by 147
Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice
Liu, X., Wang, Z., & Liu, F. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127880 · Cited by 143
Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study
Vélez, M. P., Arbuckle, T. E., & Fraser, W. D. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.01.005 · Cited by 139
Association of urinary concentrations of bisphenols with type 2 diabetes mellitus: A case-control study
Duan, Y., Yao, Y., Wang, B., Han, L., Wang, L., Sun, H., & Chen, L. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.09.093 · Cited by 133
Usefulness of bovine and porcine IVM/IVF models for reproductive toxicology
dos Santos, R. R., Schoevers, E. J., & Roelen, B. A. J. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-117 · Cited by 131
A review of atmospheric microplastics pollution: In-depth sighting of sources, analytical methods, physiognomies, transport and risks
Munyaneza, J., Jia, Q., Qaraah, F. A. A., Hossain, M. F., Wu, C., Zhen, H., & Xiu, G. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153339 · Cited by 134
Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc
Pfeifer, D., Chung, Y. M., & Hu, M. C. ‐. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409199 · Cited by 127
Human health risk assessment of bisphenol A (BPA) through meat products
Wang, X., Nag, R., Brunton, N. P., Siddique, M. A. B., Harrison, S. M., Monahan, F. J., & Cummins, E. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113734 · Cited by 126
Theoretical insight into the adsorption of aromatic compounds on graphene oxide
Tang, H., Zhao, Y., Shan, S., Yang, X., Liu, D., Cui, F., & Xing, B. (2018) · Environmental Science Nano · doi:10.1039/c8en00384j · Cited by 124
A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort
Aker, A. M., Ferguson, K. K., Rosario, Z., Mukherjee, B., Alshawabkeh, A. N., Calafat, A. M., Cordero, J. F., & Meeker, J. D. (2019) · Environmental Health · doi:10.1186/s12940-019-0459-5 · Cited by 123
Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review
Peivasteh-Roudsari, L., Barzegar-Bafrouei, R., Sharifi, K. A., Salim, S. A., Karami, M., Abedinzadeh, S., Asadinezhad, S., Tajdar‐oranj, B., Mahdavi, V., Alizadeh, A. M., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18140 · Cited by 137
The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice
Berger, A., Ziv‐Gal, A., Cudiamat, J., Wang, W., Zhou, C., & Flaws, J. A. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.12.004 · Cited by 121
Self-citation
The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2α/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity
Yin, L., Dai, Y., Cui, Z., JIANG, X. H., Liu, W., Han, F., Ao, L., Cao, J., & Liu, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.11.013 · Cited by 120
Bisphenol A detection based on nano gold-doped molecular imprinting electrochemical sensor with enhanced sensitivity
Han, E., Pan, Y., Li, L., & Cai, J. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136608 · Cited by 117
Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes
González-Rojo, S., Lombó, M., Fernández-Díez, C., & Herráez, M. P. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.01.127 · Cited by 115
In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction
Barbonetti, A., Castellini, C., Giammarco, N. D., Santilli, G., Francavilla, S., & Francavilla, F. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.09.014 · Cited by 111
The epigenetic impacts of endocrine disruptors on female reproduction across generations†
Rattan, S., & Flaws, J. A. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz081 · Cited by 116
Self-citation
Potential effects of biodegradable single-use items in the sea: Polylactic acid (PLA) and solitary ascidians
Anderson, G., & Shenkar, N. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115364 · Cited by 118
CLARITY‐BPA academic laboratory studies identify consistent low‐dose Bisphenol A effects on multiple organ systems
Prins, G. S., Patisaul, H. B., Belcher, S. M., & Vandenberg, L. N. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13125 · Cited by 112
Urinary concentrations of bisphenol A, parabens and phthalate metabolite mixtures in relation to reproductive success among women undergoing in vitro fertilization
Mínguez‐Alarcón, L., Messerlian, C., Bellavia, A., Gaskins, A. J., Chiu, Y., Ford, J. B., Azevedo, A., Petrozza, J. C., Calafat, A. M., Hauser, R. B., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.02.025 · Cited by 108
Self-citation
From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality
Virant‐Klun, I., Kumalić, S. I., & Pinter, B. (2022) · Antioxidants · doi:10.3390/antiox11081617 · Cited by 110
Environmental Contaminants Affecting Fertility and Somatic Health
Chiang, C., Mahalingam, S., & Flaws, J. A. (2017) · Seminars in Reproductive Medicine · doi:10.1055/s-0037-1603569 · Cited by 113
Self-citation
Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes
Smarr, M. M., Grantz, K. L., Sundaram, R., Maisog, J. M., Kannan, K., & Louis, G. M. B. (2015) · Environmental Health · doi:10.1186/s12940-015-0060-5 · Cited by 102
Effects of bisphenol A analogues on reproductive functions in mice
Shi, M., Sekulovski, N., MacLean, J. A., & Hayashi, K. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.06.134 · Cited by 102
Food Packaging and Chemical Migration: A Food Safety Perspective
Seref, N., & Çufaoğlu, G. (2025) · Journal of Food Science · doi:10.1111/1750-3841.70265 · Cited by 100
NIEHS/FDA CLARITY-BPA research program update
Heindel, J. J., Newbold, R. R., Bucher, J. R., Camacho, L., Delclos, K. B., Lewis, S. M., Vanlandingham, M. M., Churchwell, M. I., Twaddle, N. C., McLellen, M., et al. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.07.075 · Cited by 99
Self-citation
Development and validation of LC–MS/MS method for quantification of bisphenol A and estrogens in human plasma and seminal fluid
Vítků, J., Chlupáčová, T., Kolátorová, L., Hampl, R., Hill, M., Heráček, J., Bičı́ková, M., & Stárka, L. (2015) · Talanta · doi:10.1016/j.talanta.2015.03.013 · Cited by 98
Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand–ERα Complexes
Li, Y., Perera, L., Coons, L. A., Burns, K. A., Ramsey, J. T., Pelch, K. E., Houtman, R., van Beuningen, R., Teng, C. T., & Korach, K. S. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2505 · Cited by 99
Endocrine-Disrupting Chemicals’ (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1
Buoso, E., Masi, M., Racchi, M., & Corsini, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239229 · Cited by 104
Dynamics of the Ovarian Reserve and Impact of Genetic and Epidemiological Factors on Age of Menopause1
Pelosi, E., Simonsick, E. M., Forabosco, A., García‐Ortíz, J. E., & Schlessinger, D. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.127381 · Cited by 100
Endocrine‐Disrupting Chemicals and Reproductive Health
Zlatnik, M. G. (2016) · Journal of Midwifery & Women s Health · doi:10.1111/jmwh.12500 · Cited by 113
Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study
Patel, S. A., Brehm, E., Gao, L., Rattan, S., Ziv‐Gal, A., & Flaws, J. A. (2017) · Endocrinology · doi:10.1210/en.2016-1887 · Cited by 94
Self-citation
Bisphenol A and ovarian steroidogenesis
Bloom, M. S., Mok-Lin, E. Y., & Fujimoto, V. Y. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.08.021 · Cited by 91
Prenatal Exposure to Bisphenol A Analogues on Male Reproductive Functions in Mice
Shi, M., Sekulovski, N., MacLean, J. A., & Hayashi, K. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy061 · Cited by 92
Response Characteristics of Bisphenols on a Metal–Organic Framework-Based Tyrosinase Nanosensor
Lu, X., Wang, X., Wu, L., Wu, L., Dhanjai, D., Fu, L., Gao, Y., & Chen, J. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b05008 · Cited by 92
Bisphenol S negatively affects the meotic maturation of pig oocytes
Žalmanová, T., Hošková, K., Nevoral, J., Adámková, K., Kott, T., Šulc, M., Kotíková, Z., Prokešová, Š., Jílek, F., Králíčková, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00570-5 · Cited by 91
Bisphenol A and Male Fertility: Myths and Realities
Castellini, C., Totaro, M., Parisi, A., D’Andrea, S., Lucente, L., Cordeschi, G., Francavilla, S., Francavilla, F., & Barbonetti, A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00353 · Cited by 93
Bisphenol A Interaction With Brain Development and Functions
Negri‐Cesi, P. (2015) · Dose-Response · doi:10.1177/1559325815590394 · Cited by 89
Bisphenol AF compromises blood-testis barrier integrity and sperm quality in mice
Wu, D., Huang, C., Jiao, X., Ding, Z., Zhang, S.-X., Miao, Y., & Huo, L. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124410 · Cited by 89
Bisphenol A exposure alters placentation and causes preeclampsia‐like features in pregnant mice involved in reprogramming of DNA methylation of WNT2
Ye, Y., Tang, Y., Xiong, Y., Feng, L., & Li, X. (2018) · The FASEB Journal · doi:10.1096/fj.201800934rrr · Cited by 88
Urinary bisphenol A concentrations and association with in vitro fertilization outcomes among women from a fertility clinic
Mínguez‐Alarcón, L., Gaskins, A. J., Chiu, Y., Williams, P. L., Ehrlich, S., Chavarro, J. E., Petrozza, J. C., Ford, J. B., Calafat, A. M., & Hauser, R. B. (2015) · Human Reproduction · doi:10.1093/humrep/dev183 · Cited by 88
Self-citation
Maternal and paternal preconception exposure to phenols and preterm birth
Mustieles, V., Zhang, Y., Yland, J. J., Braun, J. M., Williams, P. L., Wylie, B. J., Attaman, J., Ford, J. B., Azevedo, A., Calafat, A. M., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.105523 · Cited by 86
Self-citation
Gas chromatography–mass spectrometry analysis of nine bisphenols in canned meat products and human risk estimation
Cunha, S. C., Inácio, T., Almada, M., Ferreira, R., & Fernandes, J. O. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109293 · Cited by 82
Effect of maternal PCOS and PCOS-like phenotype on the offspring's health
Puttabyatappa, M., Cardoso, R. C., & Padmanabhan, V. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.11.030 · Cited by 88
Self-citation
The role of epigenetic changes in preeclampsia
Kamrani, A., Alipourfard, I., Ahmadi‐Khiavi, H., Yousefi, M., Rostamzadeh, D., Izadi, M., & Ahmadi, M. (2019) · BioFactors · doi:10.1002/biof.1542 · Cited by 87
Effects of Bisphenols on Testicular Steroidogenesis
Barbagallo, F., Condorelli, R. A., Mongioì, L. M., Cannarella, R., Aversa, A., Calogero, A. E., & Vignera, S. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00373 · Cited by 87
Differences in Bisphenol A and Estrogen Levels in the Plasma and Seminal Plasma of Men With Different Degrees of Infertility
Vítků, J., SOSVOROVA, L., Chlupáčová, T., Hampl, R., Hill, M., Sobotka, V., Heráček, J., BICIKOVA, M., & Stárka, L. (2015) · Physiological Research · doi:10.33549/physiolres.933090 · Cited by 86
Relationships Between Urinary Phthalate Metabolite and Bisphenol A Concentrations and Vitamin D Levels in U.S. Adults: National Health and Nutrition Examination Survey (NHANES), 2005–2010
Johns, L. E., Ferguson, K. K., & Meeker, J. D. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2134 · Cited by 82
Associations of Trimester-Specific Exposure to Bisphenols with Size at Birth: A Chinese Prenatal Cohort Study
Hu, J., Zhao, H., Braun, J. M., Zheng, T., Zhang, B., Xia, W., Zhang, W., Li, J., Zhou, Y. R., Li, H., et al. (2019) · Environmental Health Perspectives · doi:10.1289/ehp4664 · Cited by 86
Characteristics of the alkylphenol and bisphenol A distributions in marine organisms and implications for human health: A case study of the East China Sea
Gu, Y., Yu, J., Hu, X., & Yin, D. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.09.011 · Cited by 82
Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation
Chianese, R., Viggiano, A., Urbanek, K., Cappetta, D., Troisi, J., Scafuro, M., Guida, M., Esposito, G., Ciuffreda, L. P., Rossi, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21076-8 · Cited by 79
Exposure of BPA and its alternatives like BPB, BPF, and BPS impair subsequent reproductive potentials in adult female Sprague Dawley rats
Ijaz, S., Ullah, A., Shaheen, G., & Jahan, S. (2019) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2019.1652873 · Cited by 78
Cosmetics as endocrine disruptors: are they a health risk?
Nicolopoulou-Stamati, P., Hens, L., & Sasco, A. J. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9329-4 · Cited by 78
Bisphenol A: Targeting metabolic tissues
Chevalier, N., & Fénichel, P. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9333-8 · Cited by 77
Determination of bisphenol A and bisphenol S concentrations and assessment of estrogen- and anti-androgen-like activities in thermal paper receipts from Brazil, France, and Spain
Molina-Molina, J.-M., Jiménez-Díaz, I., Fernández, M. F., Rodríguez‐Carrillo, A., Peinado, F. M., Mustieles, V., Barouki, R., Piccoli, C., Olea, N., & Freire, C. (2018) · Environmental Research · doi:10.1016/j.envres.2018.12.046 · Cited by 82
The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes
Land, K. L., Miller, F. G., Fugate, A. C., & Hannon, P. R. (2022) · Molecular Reproduction and Development · doi:10.1002/mrd.23652 · Cited by 81
An Investigation of the Endocrine-Disruptive Effects of Bisphenol A in Human and Rat Fetal Testes
Maamar, M. B., Lesné, L., Lethimonier, C., Coiffec, I., Lassurguère, J., Lavoué, V., Deceuninck, Y., Antignac, J., Bizec, B. L., Perdu-Durand, E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117226 · Cited by 83
Removal strategies for endocrine disrupting chemicals using cellulose-based materials as adsorbents: A review
Tapia-Orozco, N., IbarraCabrera, R., Tecante, A., Gimeno, M., Parra‐Saldívar, R., & García‐Arrazola, R. (2016) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2016.06.025 · Cited by 77
Urinary Bisphenol A (BPA) Concentrations among Workers in Industries that Manufacture and Use BPA in the USA
Hines, C. J., Jackson, M. V., Deddens, J. A., Clark, J. C., Ye, X., Christianson, A. L., Meadows, J. W., & Calafat, A. M. (2016) · Annals of Work Exposures and Health · doi:10.1093/annweh/wxw021 · Cited by 76
Exposures to Endocrine Disrupting Chemicals in Consumer Products—A Guide for Pediatricians
Wong, K. H., & Durrani, T. S. (2017) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2017.04.002 · Cited by 80
Long-term exposure to very low doses of bisphenol S affects female reproduction
Nevoral, J., Kolinko, Y., Moravec, J., Žalmanová, T., Hošková, K., Prokešová, Š., Klein, P., Ghaibour, K. C., Hošek, P., Štiavnická, M., et al. (2018) · Reproduction · doi:10.1530/rep-18-0092 · Cited by 75
The Mechanisms of Plastic Food-Packaging Monomers’ Migration into Food Matrix and the Implications on Human Health
Muzeza, C., Ngole-Jeme, V. M., & Msagati, T. A. M. (2023) · Foods · doi:10.3390/foods12183364 · Cited by 76
Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy
Ferguson, K. K., Cantonwine, D. E., McElrath, T. F., Mukherjee, B., & Meeker, J. D. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.002 · Cited by 78
Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth
Zhang, Y., Mustieles, V., Williams, P. L., Wylie, B. J., Souter, I. C., Calafat, A. M., Demokritou, M., Lee, A., Vagios, S., Hauser, R. B., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106440 · Cited by 72
Self-citation
Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of male mice
Rahman, M. S., Pang, W., Ryu, D., Park, Y.-J., Ryu, B., & Pang, M. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125791 · Cited by 74
Does BPA alter steroid hormone synthesis in human granulosa cellsin vitro?
Mansur, A., Adir, M., Yerushalmi, G., Hourvitz, A., Gitman, H., Yung, Y., Orvieto, R., & Machtinger, R. (2016) · Human Reproduction · doi:10.1093/humrep/dew088 · Cited by 77
Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review
Žalmanová, T., Hošková, K., Nevoral, J., Prokešová, Š., Zámostná, K., Kott, T., & Petr, J. (2016) · Czech Journal of Animal Science · doi:10.17221/81/2015-cjas · Cited by 74
Prenatal Exposure to Bisphenol A, E, and S Induces Transgenerational Effects on Male Reproductive Functions in Mice
Shi, M., Whorton, A. E., Sekulovski, N., MacLean, J. A., & Hayashi, K. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz207 · Cited by 73
Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure
Jorgensen, E. M., Alderman, M. H., & Taylor, H. S. (2016) · The FASEB Journal · doi:10.1096/fj.201500089r · Cited by 75
Self-citation

Authors: Peretz, J., Vrooman, L., Ricke, W. A., Hunt, P. A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H. S., Swan, S. H., VandeVoort, C. A., & Flaws, J. A.
Affiliations: University of Illinois Urbana-Champaign (US)
Washington State University (US)
University of Wisconsin–Madison (US)
Cincinnati Children's Hospital Medical Center (US)
Harvard University (US)
University of Michigan (US)
Yale University (US)
Icahn School of Medicine at Mount Sinai (US)
University of California, Davis (US)
Corresponding author: Flaws, Jodi A.
ORCID: Peretz, Jackye
Vrooman, Lisa
Ricke, William A.
Hunt, Patricia A.
Ehrlich, Shelley
Hauser, Russ
Padmanabhan, Vasantha
Taylor, Hugh S.
Swan, Shanna H.
VandeVoort, Catherine A.
Flaws, Jodi A.
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2014-06-04
Volume: 122
Issue: 8
Pages: 775-786
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.1307728
PMC: PMC4123031
OpenAlex: W2020338693
Cited by: 555
References: 140
Citations by year: 2026: 28 · 2025: 32 · 2024: 34 · 2023: 51 · 2022: 38 · 2021: 46 · 2020: 51 · 2019: 43 · 2018: 56 · 2017: 43 · 2016: 68 · 2015: 56 · 2014: 7
FWCI: 6.00
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/licenses/by/4.0/ (vor, 1304 d)
Locations: Environmental Health Perspectives (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
eScholarship (California Digital Library) (submittedVersion, public-domain)
Funders: National Institutes of Health (P51OD011107)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572)
National Institute of Environmental Health Sciences (R01ES16541, RC2ES18764, R01ES009718, R01ES016770, R01ES9718, R01ES016541, R01ES019178, P20ES018163, R01ES16770, P01ES022844, R01ES017005, R01ES013527, R01 ES13527, P01ES022848, R01ES17005, RC2ES018764, P30ES023515, P30ES017885)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: bisphenol A, reproductive toxicity, endocrine disruptors, female reproduction, male reproduction, ovarian toxicity, uterine toxicity, testicular toxicity, meiosis, steroidogenesis, oocyte quality, in vitro fertilization, endometrial proliferation, endometrial receptivity, implantation failure, birth outcomes, hyperandrogenism, sexual dysfunction, mechanism of action
MeSH terms: Bisphenol A Compounds, Animals, Benzhydryl Compounds, Female, Humans, Male, Embryo Implantation, Phenols, Pregnancy, Reproduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks