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High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
Open accessAbstract
Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breast cancer study and in a reproductive study, respectively. Adipose samples (n = 32) were analyzed by low-resolution mass spectrometry in negative-ion chemical ionization mode, whereas serum samples (n = 50) were analyzed by dual-column gas chromatography with electron capture detection. The results confirmed our earlier findings. Concentrations of 2,2,4,4 -tetrabromodiphenyl ether (BDE-47) in contemporary California women ranged between 5 and 510 ng/g lipid, with a median (16.5 ng/g lipid) 3-10 times higher than those reported from Europe. In contrast, PBDEs were not measurable in any of 420 archived serum samples collected in the 1960s from San Francisco Bay Area women participating in a study of child development. BDE-47 concentrations did not increase with age or with concentrations of a polychlorinated biphenyl (PCB-153), suggesting other routes of exposure in addition to diet. Rising body burdens of endocrine-disrupting chemicals such as PBDEs may pose a potential public health threat.
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Cited by
Harrad, S., de Wit, C. A., Abdallah, M. A.-E., Bergh, C., Björklund, J. A., Covaci, A., Darnerud, P. O., de Boer, J., Diamond, M., Huber, S., et al. (2010) · Environmental Science & Technology · doi:10.1021/es903476t · Cited by 300
Zota, A. R., Rudel, R. A., Morello-Frosch, R. A., & Brody, J. G. (2008) · Environmental Science & Technology · doi:10.1021/es801792z · Cited by 227
Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study
Hertz-Picciotto, I., Bergman, Å., Fängström, B., Rose, M., Krakowiak, P., Pessah, I., Hansen, R., & Bennett, D. H. (2011) · Environmental Health · doi:10.1186/1476-069x-10-1 · Cited by 167
Dingemans, M. M. L., Ramakers, G. M. J., Gardoni, F., van Kleef, R. G. D. M., Bergman, Å., Di Luca, M., van den Berg, M., Westerink, R. H. S., & Vijverberg, H. P. M. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9860 · Cited by 133
Shah, A., Coburn, C. G., Watson-Siriboe, A., Whitley, R., Shahidzadeh, A., Gillard, E. R., Nichol, R., Leon-Olea, M., Gaertner, M., Kodavanti, P. R. S., et al. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.014 · Cited by 24
Metadata
- Authors
- Petreas, M., She, J., Brown, F. R., Winkler, J., Windham, G., Rogers, E., Zhao, G., Bhatia, R., & Charles, M. J.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-07
- Volume
- 111
- Issue
- 9
- Pages
- 1175-1179
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2005416593
- Cited by
- 182
- References
- 0
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Petreas, M., She, J., Brown, F. R., Winkler, J., Windham, G., Rogers, E., Zhao, G., Bhatia, R., & Charles, M. J. (2003). High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women. Environmental Health Perspectives. https://doi.org/10.1289/ehp.6220
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