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Toxicology of chlorinated dibenzo-p-dioxins.
Open accessAbstract
Severe toxicological responses have been associated with certain chlorodibenzodioxins. One of these responses is chloracne, a folliculosis first associated with skin contamination by chlorohydrocarbons in 1899 (1)). Serious outbreaks of chloracne-like lesions associated with runaway reactions in the production of 2,4,5-trichlorophenol occurred in Germany in the early 1950's (2). 2,4,5Trichlorophenol itself does not cause acne (3), but the contaminants which may be formed in the uncontrolled production of 2,4,5-trichlorophenol are extremely potent acnegens (2). 2,3,7,8-Tetrachlorodibenzo-pdioxin and triand tetrachlorodibenzofuran were isolated from the contaminants formed in 2,4,5-trichlorophenol production and were demonstrated to be strongly positive acnegens when applied to rabbit ears (3). By using the rabbit ear test, the acnegenic potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) was confirmed in 1962 (4). In addition, 2,3,7,8-TCDD is extremely toxic in the chick embryo assay (5) and is highly embryotoxic in rats (6). Another chlorodibenzodioxin, hexachlorodibenzo-pdioxin (HCDD), is known to be positive for the chick edema factor, a condition characterized by hydropericardium, ascites, and anasarca (5, 7).
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“In some cases, receptor structural variation within a species corresponds to differing affinities for ligand, sensitivity to ligand-induced responses, or receptor stability (Schwetz et al. 1973; Henck et al. 1981; Jain et al. 1994; Poland et al. 1994; Andreasen et al. 2002).”
Background
Metadata
- Authors
- Schwetz, B. A., Norris, J. M., Sparschu, G. L., Rowe, U. K., Gehring, P. J., Emerson, J. L., & Gerbig, C. G.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1973-09
- Volume
- 5
- Pages
- 87-99
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2008143869
- Cited by
- 492
- References
- 0
- FWCI
- 17.01
- Type
- journal article
- Language
- en
- Open access
- gold
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