The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Tubular and Glomerular Kidney Effects in Swedish Women with Low Environmental Cadmium Exposure
Open accessAbstract
Cadmium is a well-known nephrotoxic agent in food and tobacco, but the exposure level that is critical for kidney effects in the general population is not defined. Within a population-based women's health survey in southern Sweden (Women's Health in the Lund Area, WHILA), we investigated cadmium exposure in relation to tubular and glomerular function, from 1999 through early 2000 in 820 women (71% participation rate) 53-64 years of age. Multiple linear regression showed cadmium in blood (median, 0.38 microg/L) and urine (0.52 microg/L; density adjusted = 0.67 microg/g creatinine) to be significantly associated with effects on renal tubules (as indicated by increased levels of human complex-forming protein and N-acetyl-beta-D-glucosaminidase in urine), after adjusting for age, body mass index, blood lead, diabetes, hypertension, and regular use of nephrotoxic drugs. The associations remained significant even at the low exposure in women who had never smoked. We also found associations with markers of glomerular effects: glomerular filtration rate and creatinine clearance. Significant effects were seen already at a mean urinary cadmium level of 0.6 microg/L (0.8 microg/g creatinine). Cadmium potentiated diabetes-induced effects on kidney. In conclusion, tubular renal effects occurred at lower cadmium levels than previously demonstrated, and more important, glomerular effects were also observed. Although the effects were small, they may represent early signs of adverse effects, affecting large segments of the population. Subjects with diabetes seem to be at increased risk.
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Cites
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Serum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis
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Self-citationCalculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L
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Low level exposure to cadmium and early kidney damage: the OSCAR study
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Self-citationUrinary Cadmium, Impaired Fasting Glucose, and Diabetes in the NHANES III
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Acetaminophen, Aspirin, and Chronic Renal Failure
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Cited by
Current status of cadmium as an environmental health problem
Järup, L., & Åkesson, A. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.04.020 · Cited by 2,355
Self-citationEnvironmental factors in cardiovascular disease
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Lead-related nephrotoxicity: A review of the epidemiologic evidence
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Recommendations for Medical Management of Adult Lead Exposure
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Metadata
- Authors
- Åkesson, A., Lundh, T., Vahter, M., Bjellerup, P., Lidfeldt, J., Nerbrand, C., Samsioe, G., Strömberg, U., & Skerfving, S.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-11
- Volume
- 113
- Issue
- 11
- Pages
- 1627-1631
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1983037167
- Cited by
- 465
- References
- 30
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- Åkesson, A., Lundh, T., Vahter, M., Bjellerup, P., Lidfeldt, J., Nerbrand, C., Samsioe, G., Strömberg, U., & Skerfving, S. (2005). Tubular and Glomerular Kidney Effects in Swedish Women with Low Environmental Cadmium Exposure. Environmental Health Perspectives. https://doi.org/10.1289/ehp.8033
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