Cited by 245Indoor Air Quality and Microbial ExposureAsthma and respiratory diseasesOccupational exposure and asthma

Reduction in Asthma Morbidity in Children as a Result of Home Remediation Aimed at Moisture Sources

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Kercsmar, Carolyn M., Dearborn, Dorr G., Schluchter, Mark, Xue, Lintong, Kirchner, H. Lester, Sobolewski, John, Greenberg, Stuart J., Vesper, Stephen J. +1 more·2006·Environmental Health Perspectives

Abstract

Objective: Home dampness and the presence of mold and allergens have been associated with asthma morbidity. We examined changes in asthma morbidity in children as a result of home remediation aimed at moisture sources. Design: In this prospective, randomized controlled trial, symptomatic, asthmatic children (n = 62), 2–17 years of age, living in a home with indoor mold, received an asthma intervention including an action plan, education, and individualized problem solving. The remediation group also received household repairs, including reduction of water infiltration, removal of water-damaged building materials, and heating/ventilation/air-conditioning alterations. The control group received only home cleaning information. We measured children’s total and allergen-specific serum immuno-globulin E, peripheral blood eosinophil counts, and urinary cotinine. Environmental dust samples were analyzed for dust mite, cockroach, rodent urinary protein, endotoxin, and fungi. The follow-up period was 1 year. Results: Children in both groups showed improvement in asthma symptomatic days during the preremediation portion of the study. The remediation group had a significant decrease in symptom days (p = 0.003, as randomized; p = 0.004, intent to treat) after remodeling, whereas these parameters in the control group did not significantly change. In the postremediation period, the remediation group had a lower rate of exacerbations compared with control asthmatics (as treated: 1 of 29 vs. 11 of 33, respectively, p = 0. 003; intent to treat: 28.1% and 10.0%, respectively, p = 0.11). Conclusion: Construction remediation aimed at the root cause of moisture sources and combined with a medical/behavioral intervention significantly reduces symptom days and health care use for asthmatic children who live in homes with a documented mold problem.

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  • Even in US homes with central heating, poorly designed ventilation systems have been linked to idiopathic pulmonary hemorrhage and fatalities.

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  1. Institute of Medicine of the National Academies 2004. Damp Indoor Spaces and Health. Washington, DC:National Academies Press. 25009878

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Authors
Kercsmar, C. M., Dearborn, D. G., Schluchter, M., Xue, L., Kirchner, H. L., Sobolewski, J., Greenberg, S. J., Vesper, S. J., & Allan, T.
Affiliations
  • Rainbow Babies & Children's Hospital (US)
  • Cuyahoga County Board of Health (US)
  • Environmental Health Watch, Cleveland, Ohio, USA
  • Environmental Protection Agency (US)
Corresponding author
Kercsmar, Carolyn M.
Venue
Environmental Health Perspectives
Published
2006-04-25
Volume
114
Issue
10
Pages
1574-1580
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
OpenAlex
W2064547912
Cited by
245
References
26
Citations by year
2026: 6 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 14 · 2021: 12 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 15 · 2016: 14 · 2015: 17 · 2014: 12 · 2013: 15 · 2012: 17
FWCI
8.37
Type
journal article
Language
en
Open access
Locations
  • Environmental Health Perspectives (publishedVersion, public-domain)
  • Europe PMC (PubMed Central) (publishedVersion, public-domain)
  • PubMed (publishedVersion)
Funders
  • U.S. Environmental Protection Agency
  • U.S. Department of Housing and Urban Development
  • National Institutes of Health
  • National Center for Research Resources (M01RR000080, M01RR00080)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
childhood asthma, indoor mold, moisture control, dampness, asthma exacerbations, asthma action plan, specific IgE, eosinophils, urinary cotinine, house dust mites, cockroach allergens, rodent allergens, endotoxin, water infiltration
MeSH terms
Adolescent, Allergens, Asthma, Child, Child, Preschool, Dust, Housing, Humans, Humidity, Prospective Studies

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