Fish acute toxicity syndromes and their use in the QSAR approach to hazard assessment

Quantitative structure-activity relationships in fish toxicity studies Part 1: Relationship for 50 industrial pollutants

Könemann, H. (1981) · Toxicology · doi:10.1016/0300-483x(81)90130-x · Cited by 631

Structure–Toxicity Relationships for the Fathead Minnow, Pimephales promelas: Narcotic Industrial Chemicals

Veith, G. D., Call, D. J., & Brooke, L. T. (1983) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f83-096 · Cited by 573

The use of chemical potentials as indices of toxicity

Ferguson, J. F. (1939) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1939.0030 · Cited by 559

Evaluation of Tests with Early Life Stages of Fish for Predicting Long-Term Toxicity

McKim, J. M. (1977) · Journal of the Fisheries Research Board of Canada · doi:10.1139/f77-172 · Cited by 493

Mechanisms of Selective Action of Pyrethroid Insecticides

Casida, J. E., Gammon, D. W., Glickman, A. H., & Lawrence, L. J. (1983) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.23.040183.002213 · Cited by 414

The Control of Respiration and Circulation in Fish During Exercise and Hypoxia

Randall, D. J. (1982) · Journal of Experimental Biology · doi:10.1242/jeb.100.1.275 · Cited by 412

Some Physical Mechanisms in Narcosis.

Mullins, L. J. (1954) · Chemical Reviews · doi:10.1021/cr60168a003 · Cited by 344

The Circulatory System

Nilsson, S. (1983) · Zoophysiology · doi:10.1007/978-3-642-81974-2_7 · Cited by 321

Effects of copper on branchial ionoregulation in the rainbow trout,Salmo gairdneri Richardson

Laurén, D. J., & McDonald, D. G. (1985) · Journal of Comparative Physiology B · doi:10.1007/bf00694455 · Cited by 293

Morphometrics of fish gills

Hughes, G. M. (1972) · Respiration Physiology · doi:10.1016/0034-5687(72)90014-x · Cited by 250

Phenol mechanism of toxic action classification and prediction: a decision tree approach

Ren, S. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(03)00236-4 · Cited by 29

Predicting toxic action mechanisms of phenols using AdaBoost Learner

Niu, B., Jin, Y., Lu, W., & Li, G. (2008) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2008.11.003 · Cited by 29

Ecotoxicity prediction using mechanism- and non-mechanism-based QSARs: a preliminary study

Ren, S. (2003) · Chemosphere · doi:10.1016/s0045-6535(03)00573-3 · Cited by 29

Computational Methods to Predict Toxicity

Cronin, M., & Yoon, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813697-3.00031-7 · Cited by 28

Modelling acute oral mammalian toxicity. 1. Definition of a quantifiable baseline effect

Koleva, Y. K., Cronin, M., Madden, J. C., & Schwöbel, J. A. H. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.04.015 · Cited by 27

Toxicity of some prevalent organic chemicals to tadpoles and comparison with toxicity to fish based on mode of toxic action

Wang, S., Yan, L. C., Zheng, S. S., Li, T. T., Fan, L. Y., Huang, T., Li, C., & Zhao, Y. H. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.09.105 · Cited by 27

Acute toxicity and behavioral effects of acrylates and methacrylates to juvenile fathead minnows

Russom, C. L., Drummond, R. A., & Huffman, A. D. (1988) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf02021005 · Cited by 26

Discriminating toxicant classes by mode of action: 4. Baseline and excess toxicity

Nendza, M., Müller, M., & Wenzel, A. (2014) · SAR and QSAR in environmental research · doi:10.1080/1062936x.2014.907205 · Cited by 25

Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected β-olefinic alcohols

Przybylak, K. R., Schultz, T. W., Richarz, A.-N., Mellor, C. L., Escher, S. E., & Cronin, M. (2016) · Computational Toxicology · doi:10.1016/j.comtox.2016.11.001 · Cited by 25

Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected 2-alkyl-1-alkanols

Schultz, T. W., Przybylak, K. R., Richarz, A.-N., Mellor, C. L., Bradbury, S. P., & Cronin, M. (2017) · Computational Toxicology · doi:10.1016/j.comtox.2017.02.005 · Cited by 25

Discriminating toxicant classes by mode of action: 3. Substructure indicators

Nendza, M., & Müller, M. (2007) · SAR and QSAR in environmental research · doi:10.1080/10629360601054354 · Cited by 25

The use of Mechanisms and Modes of Toxic Action in Integrated Testing Strategies: The Report and Recommendations of a Workshop held as part of the European Union OSIRIS Integrated Project

Vonk, J. A., Benigni, R., Hewitt, M., Nendza, M., Segner, H. E., van de Meent, D., & Cronin, M. (2009) · Alternatives to Laboratory Animals · doi:10.1177/026119290903700512 · Cited by 25

Population growth impairment of aliphatic alcohols to Tetrahymena

Schultz, T. W., Seward, J. R., Foster, K. A., & Tucker, V. A. (2004) · Environmental Toxicology · doi:10.1002/tox.10145 · Cited by 25

Acute aquatic toxicity of alkyl phenol ethoxylates

Schüürmann, G. (1991) · Ecotoxicology and Environmental Safety · doi:10.1016/0147-6513(91)90024-j · Cited by 25

QSAR for methyl- and/or chloro-substituted anilines and the polar narcosis mechanism of toxicity

Arnold, L. M., Lin, D. T. S., & Schultz, T. W. (1990) · Chemosphere · doi:10.1016/0045-6535(90)90390-f · Cited by 25

Scientific and Regulatory Perspectives on Chemical Risk Assessment of Pesticides in the European Union

Buonsenso, F. (2025) · Journal of Xenobiotics · doi:10.3390/jox15050173 · Cited by 27

Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected n-alkanols

Schultz, T. W., Przybylak, K. R., Richarz, A.-N., Mellor, C. L., Escher, S. E., Bradbury, S. P., & Cronin, M. (2017) · Computational Toxicology · doi:10.1016/j.comtox.2017.02.002 · Cited by 24

An exploratory study of the use of multivariate techniques to determine mechanisms of toxic action

Ren, S., Frymier, P. D., & Schultz, T. W. (2003) · Ecotoxicology and Environmental Safety · doi:10.1016/s0147-6513(02)00132-x · Cited by 24

Determination of “fitness-for-purpose” of quantitative structure-activity relationship (QSAR) models to predict (eco-)toxicological endpoints for regulatory use

Belfield, S. J., Enoch, S. J., Firman, J. W., Madden, J. C., Schultz, T. W., & Cronin, M. (2021) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2021.104956 · Cited by 23

Prediction of environmental toxicity based on structure-activity relationships using mechanistic information

Hermens, J. L. M. (1995) · The Science of The Total Environment · doi:10.1016/0048-9697(95)04684-5 · Cited by 23

Model-based QSAR for ionizable compounds: Toxicity of phenols against Tetrahymena pyriformis

Piršelová, K., Baláž, Š., & Schultz, T. W. (1996) · Archives of Environmental Contamination and Toxicology · doi:10.1007/bf00215795 · Cited by 23

Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT

Varga, E., Prause, H.-C., Riepl, M., Hochmayr, N., Berk, D., Attakpah, E., Kiss, E., Medić, N., Favero, G. D., Larsen, T. O., et al. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03663-5 · Cited by 22

Pharmacokinetics and metabolism of triclopyr butoxyethyl ester in coho salmon

Barron, M. G., Mayes, M. A., Murphy, P. G., & Nolan, R. J. (1990) · Aquatic Toxicology · doi:10.1016/0166-445x(90)90074-y · Cited by 22

Classification of baseline toxicants for QSAR predictions to replace fish acute toxicity studies

Nendza, M., Müller, M., & Wenzel, A. (2017) · Environmental Science Processes & Impacts · doi:10.1039/c6em00600k · Cited by 21

Discriminating Redox Cycling and Arylation Pathways of Reactive Chemical Toxicity in Trout Hepatocytes

Schmieder, P. K. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg016 · Cited by 21

Safety of azamethiphos in eel, seabass and trout

Intorre, L. (2003) · Pharmacological Research · doi:10.1016/j.phrs.2003.08.002 · Cited by 21

Comparative Assessment of Multiresponse Regression Methods for Predicting the Mechanisms of Toxic Action of Phenols

Ren, S., & Kim, H. (2003) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci034092y · Cited by 21

QSARs for selected aliphatic and aromatic amines

Schultz, T. W., Wilke, T. S., Bryant, S. E., & Hosein, L. M. (1991) · The Science of The Total Environment · doi:10.1016/0048-9697(91)90211-v · Cited by 20

Defence mechanisms: the role of physiology in current and future environmental protection paradigms

Glover, C. N. (2018) · Conservation Physiology · doi:10.1093/conphys/coy012 · Cited by 19

Target site model: Application of the polyparameter target lipid model to predict aquatic organism acute toxicity for various modes of action

Boone, K. S., & Toro, D. M. D. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4278 · Cited by 19

Structure-Toxicity Relationships for Aminoalkanols: A Comparison with Alkanols and Alkanamines

Sinks, G. D., Carver, T. A., & Schultz, T. W. (1998) · SAR and QSAR in environmental research · doi:10.1080/10629369808039157 · Cited by 19

MOA-based linear and nonlinear QSAR models for predicting the toxicity of organic chemicals to Vibrio fischeri

Zhang, S., Wang, N., Su, L., Xu, X., Li, C., Qin, W., & Zhao, Y. H. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06681-y · Cited by 18

Development of an Enhanced Mechanistically Driven Mode of Action Classification Scheme for Adverse Effects on Environmental Species

Sapounidou, M., Ebbrell, D. J., Bonnell, M. A., Campos, B., Firman, J. W., Gutsell, S., Hodges, G., Roberts, J. F., & Cronin, M. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c06551 · Cited by 17

Toxicity of 3,4-dichloroaniline to perch (Perca fluviatilis) in acute and early life stage exposures

Schäfers, C., & Nagel, R. (1993) · Chemosphere · doi:10.1016/0045-6535(93)90109-i · Cited by 17

Toxicity of aryl- and benzylhalides to Daphnia magna and classification of their mode of action based on quantitative structure–activity relationship

Marchini, S., Passerini, L., Hoglund, M. D., Pino, A., & Nendza, M. (1999) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620181216 · Cited by 17

Sublethal Effect Concentrations for Nonpolar Narcosis in the Zebrafish Embryo

Massei, R., Knapen, D., Covaci, A., Blust, R., Mayer, P., & Vergauwen, L. (2021) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5170 · Cited by 16

Classification of Contaminants by Mode of Action Based onin vitroAssays

Nendza, M., Wenzel, A., & Wienen, G. (1995) · SAR and QSAR in environmental research · doi:10.1080/10629369508234013 · Cited by 16

The Internal Critical Level Concept of Nonspecific Toxicity

Chaisuksant, Y., Yu, Q., & Connell, D. (1999) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4612-1528-8_1 · Cited by 15

Molecular composition of hydroxyl radical-resistant organics in municipal solid waste leachate

Chen, W., Gu, Z., He, C., & Li, Q. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.137014 · Cited by 14

Construction of an In Silico Structural Profiling Tool Facilitating Mechanistically Grounded Classification of Aquatic Toxicants

Firman, J. W., Ebbrell, D. J., Bauer, F. J., Sapounidou, M., Hodges, G., Campos, B., Roberts, J. F., Gutsell, S., Thomas, P. C., Bonnell, M. A., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c03736 · Cited by 14

MULTICLASS CLASSIFIER FROM A COMBINATION OF LOCAL EXPERTS: TOWARD DISTRIBUTED COMPUTATION FOR REAL-PROBLEM CLASSIFIERS

König, C., Gini, G. C., Crăciun, M., & Benfenati, E. (2004) · International Journal of Pattern Recognition and Artificial Intelligence · doi:10.1142/s0218001404003423 · Cited by 13

Cytochrome P450 Expression in Rainbow Trout: An Overview

Buhler, D. R. (1995) · Springer eBooks · doi:10.1007/978-3-642-79528-2_8 · Cited by 13

The distribution, elimination, and in vivo biotransformation of aldicarb in the rainbow trout (Oncorhynchus mykiss)

Schlenk, D. (1992) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(92)90205-v · Cited by 13

Determination of LD50 of some essential oils and histopathological changes in short-term exposure to one of them in rainbow trout (Oncorhynchus mykiss)

Tabarraei, H., Hassan, J., & Mosavi, S. S. (2019) · Toxicology Research and Application · doi:10.1177/2397847318820719 · Cited by 12

The Use of Fish Physiology Literature for Predicting Fish Acute Toxicity Syndromes

Niemi, G. J., Bradbury, S., & McKim, J. (1991) · doi:10.1520/stp23576s · Cited by 12

Complex factors in hydrocarbon/water, soil/water and fish/water partitioning

Magee, P. S. (1991) · The Science of The Total Environment · doi:10.1016/0048-9697(91)90176-f · Cited by 12

Toxicity of Arsenic to Photobacterium phosphoreum, Daphnia magna, and Danio rerio at Different pH Levels

He, Q., Qu, R., Wang, X., Wei, Z., Sun, P., & Wang, Z. (2015) · CLEAN - Soil Air Water · doi:10.1002/clen.201400124 · Cited by 11

Chapter 5 Predicting toxic effects of contaminants in ecosystems using single species investigations

Altenburger, R., & Schmitt‐Jansen, M. (2003) · Trace metals and other contaminants in the environment · doi:10.1016/s0927-5215(03)80135-2 · Cited by 11

Classifying class I and class II compounds by hydrophobicity and hydrogen bonding descriptors

Ren, S. (2002) · Environmental Toxicology · doi:10.1002/tox.10074 · Cited by 11

Wirkungsforschung in der Chemischen Ökotoxikologie

Schüürmann, G., & Segner, H. E. (1994) · Umweltwissenschaften und Schadstoff-Forschung · doi:10.1007/bf02937720 · Cited by 11

Growth Kinetics of Preexposed and Naive Populations ofTetrahymena pyriformisto 2-Decanone and Acetone

Bearden, A. P., Gregory, B. W., & Schultz, T. W. (1997) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1997.1547 · Cited by 11

Comparison of modes of action between fish and zebrafish embryo toxicity for baseline, less inert, reactive and specifically-acting compounds

Zhu, D., Li, T. T., Zheng, S. S., Yan, L. C., Wang, Y., Fan, L. Y., Li, C., & Zhao, Y. H. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.09.072 · Cited by 10

Predicting Toxicological and Ecotoxicological Endpoints

Worth, A. P., Netzeva, T. I., & Patlewicz, G. Y. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6102-8_10 · Cited by 10

Fathead minnow optomotor response as a behavioral endpoint in aquatic toxicity testing

de Peyster, A., & Long, W. F. (1993) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf00201005 · Cited by 10

Utility of the QSAR modeling system for predicting the toxicity of substances on the European inventory of existing commercial chemicals∗

Fiedler, H., Hutzinger, O., & Giesy, J. P. (1990) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772249009357600 · Cited by 10

Ecotoxicology dilemmas: issues with dose, causality, response, mixtures, and modifying factors

McCarty, L. S. (2025) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgae025 · Cited by 9

Bridging chemistry and toxicology: Chemometric-driven prediction and prioritization of various drugs addressing hazardous effects for human safety

Das, S., & Ojha, P. K. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.139134 · Cited by 9

Read-across of 90-day rodent repeated-dose toxicity: A case study for selected simple aryl alcohol alkyl carboxylic acid esters

Firman, J. W., Patel, A., Date, M. S., Cronin, M., & Schultz, T. W. (2018) · Computational Toxicology · doi:10.1016/j.comtox.2018.05.001 · Cited by 9

Toward Less Hazardous Industrial Compounds: Coupling Quantum Mechanical Computations, Biomarker Responses, and Behavioral Profiles To Identify Bioactivity of SN2 Electrophiles in Alternative Vertebrate Models

Steele, W. B., Kristofco, L. A., Corrales, J., Saari, G. N., Corcoran, E. J., Hill, B. N., Mills, M. G., Gallagher, E. P., Kavanagh, T. J., Melnikov, F., et al. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00290 · Cited by 9

Modeling Toxicity

Nikinmaa, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411574-3.00018-9 · Cited by 9

Quantitative Structure-Activity Relationships for Acute Aquatic Toxicity

Cronin, M. (2003) · CRC Press eBooks · doi:10.1201/9780203010822.ch8 · Cited by 9

Volume Fraction Analyses for Selected Mechanisms of Toxic Action

Schultz, T., Jaworska, J., & Hunter, R. S. (1995) · doi:10.1520/stp12690s · Cited by 9

Toxicity of aliphatic amines on the embryos of zebrafish Danio rerio - experimental studies and QSAR

Brust, K. (2001) · Cited by 9

Multivariate Analysis of the Input and Output Data in the Fugacity Model Level I

Devillers, J., Thioulouse, J., Domine, D., Chastrette, M., & Karcher, W. (1991) · Euro courses. Chemical and environmental science · doi:10.1007/978-94-011-3198-8_9 · Cited by 9

Mixture toxicity assessment of selected insecticides to silver perch fingerling, Bidyanus bidyanus

Arora, S., & Kumar, A. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112790 · Cited by 8

Toxicological effects of aqueous extract of Genipa americana L. leaves on adult zebrafish (Danio rerio): Chemical profile, histopathological effects and lack of genotoxicity

Claro, R. O., Rivero-Wendt, C. L. G., Miranda‐Vilela, A. L., Grisólia, C. K., Facco, G. G., Moreira, D. D. L., Guilhermino, J. D. F., & Matias, R. (2023) · Toxicon · doi:10.1016/j.toxicon.2023.107305 · Cited by 8

Properties of Chemicals and Estimation Methodologies

Nendza, M., & Hermens, J. L. M. (1995) · Springer eBooks · doi:10.1007/978-94-015-8520-0_7 · Cited by 8

Mode of Action Assignment of Chemicals Using Toxicogenomics: A Case Study with Oxidative Uncouplers

Hawliczek, A., Cenijn, P. H., Legler, J., Segner, H. E., & Legradi, J. (2017) · Frontiers in Environmental Science · doi:10.3389/fenvs.2017.00080 · Cited by 7

Use of QSARs to Promote More Cost-Effective Use of Chemical Monitoring Resources. 2. Screening Chemicals for Hydrolysis Half-Lives, Henry's Law Constants, Ultimate Biodegradation Potential, Modes of Toxic Action and Bioavailability

Walker, J. D., Dimitrova, N. H., Dimitrov, S. D., Mekenyan, O. G., & Plewak, D. (2004) · Water Quality Research Journal · doi:10.2166/wqrj.2004.007 · Cited by 7

Structure–Toxicity Relationships for Selected Lactones to Tetrahymena pyriformis

Schultz, T. W. (1999) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s001289900898 · Cited by 7

The application of QSARs, extrapolation and equilibrium partitioning in aquatic effects assessment for narcotic pollutants

van Leeuwen, K., Zandt, P. T. J. V. D., Aldenberg, T., Verhaar, H. J. M., & Hermens, J. L. M. (1991) · The Science of The Total Environment · doi:10.1016/0048-9697(91)90222-z · Cited by 7

Ecological Risk Assessment of Wetlands

Kent, D. M., Jenkins, K. D., & Hobson, J. F. (2000) · CRC Press eBooks · doi:10.1201/9781420032956.ch4 · Cited by 7

QSAR in environmental sciences and drug design

Hermens, J. L. M. (1991) · The Science of The Total Environment · doi:10.1016/0048-9697(91)90165-b · Cited by 7

Structure-Toxicity Relationships of Para-Position Alkyl- and Halogen-Substituted Monoaromatic Compounds

Schultz, T., Cajina-Quezada, M., Chang, M., Lin, D., & Jain, R. (1988) · doi:10.1520/stp10304s · Cited by 7

Revolutionizing toxicity predictions of diverse chemicals to protect human health: Comparative QSAR and q-RASAR modeling

Das, S., & Ojha, P. K. (2025) · Toxicology Letters · doi:10.1016/j.toxlet.2025.06.019 · Cited by 6

Use of model parameter estimations from standard fish toxicity tests to indicate toxic mechanisms

van Wijk, R. J., & Kraaij, R. (1994) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf00192029 · Cited by 6

Detrimental impacts and QSAR baseline toxicity assessment of Japanese medaka embryos exposed to methylparaben and its halogenated byproducts

Yoon, Y., & Cho, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.171448 · Cited by 5

Behavioral and hypothalamic transcriptome analyses reveal sex-specific responses to phenanthrene exposure in the fathead minnow (Pimephales promelas)

Loughery, J. R., Crowley, E., Kidd, K. A., & Martyniuk, C. J. (2021) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2021.100905 · Cited by 5

Acute toxicity assessment and QSAR modeling of zebrafish embryos exposed to methyl paraben and its halogenated byproducts

Yoon, Y., Lee, Y., & Cho, M. (2024) · Journal of Environmental Management · doi:10.1016/j.jenvman.2024.122844 · Cited by 5

Computational Tools and Techniques to Predict Aquatic Toxicity of Some Halogenated Pollutants

Satpathy, R. (2018) · Advances in environmental engineering and green technologies book series · doi:10.4018/978-1-5225-6111-8.ch018 · Cited by 5

Modeling mode of action of industrial chemicals: Application using chemicals on Canada's Domestic Substances List (DSL)

Dimitrov, S. D., Koleva, Y. K., Lewis, M. A., Breton, R. L., Veith, G. M., & Mekenyan, O. G. (2003) · QSAR & Combinatorial Science · doi:10.1002/qsar.200390006 · Cited by 5

Models for risk assessment of reactive chemicals in aquatic toxicology

Freidig, A. P. (2000) · Utrecht University Repository (Utrecht University) · Cited by 5

Quantitative Structure—Activity Relationships (QSARs): An Integrated Multivariate Approach for Risk Assessment Studies

Tosato, M. L., Chiorboli, C., Eriksson, L., Jönsson, J., Marchini, S., Passerini, L., Pino, A., & Viganò, L. (1990) · Journal of the American College of Toxicology · doi:10.3109/10915819009078768 · Cited by 5

Suppressed swimming activity in Zebrafish (Danio rerio) exposed to 1,4,5-oxadithiepane, a sulphur mustard degradation product

Storgaard, M. S., Sanderson, H., Henriksen, P., Fauser, P., Östin, A., & Baatrup, E. (2017) · Global Security Health Science and Policy · doi:10.1080/23779497.2017.1336933 · Cited by 4

CHRONIC EFFECTS OF NONPOLAR NARCOTICS ON A MODEL MICROBIAL COMMUNITY

Jaworska, J. S., Hallam, T. B., & Schultz, T. W. (1996) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620150705 · Cited by 4

Multivariate Association of Graph-Theoretic Variables and Physicochemical Properties

Boecklen, W. J., & Niemi, G. J. (1994) · SAR and QSAR in environmental research · doi:10.1080/10629369408028841 · Cited by 4

Predicted toxicities of aryl alkanols and related compounds

Schultz, T. W., Lin, D. T. S., & Culberson, R. W. (1993) · Journal of Applied Toxicology · doi:10.1002/jat.2550130610 · Cited by 4

Development of in silico models for the prediction of toxicity incorporating ADME information

Piechota, P. (2016) · Liverpool John Moores University · doi:10.24377/ljmu.t.00004554 · Cited by 4

Modes of Action of Chemical Pollutants

Escher, B. I. (2013) · Springer eBooks · doi:10.1007/978-94-007-5704-2_68 · Cited by 4

Advancing Computational Toxicology in a Regulatory Setting: A Selected Review of the Accomplishments of Gilman D. Veith (1944–2013)

Bradbury, S. P., Russom, C. L., Schmieder, P. K., Schultz, T. W., Diderich, R., & Auer, C. M. (2015) · Applied In Vitro Toxicology · doi:10.1089/aivt.2014.0002 · Cited by 3

Developing predictive models for assessing LC of organic contaminants in Gammarus species using interpretable structural parameters

Karimi, M., Kolvari, E., Keshavarz, M. H., & Koukabi, N. (2025) · Aquatic Toxicology · doi:10.1016/j.aquatox.2025.107235 · Cited by 2

Predictive q-RASAR modeling of intrinsic toxicity of pharmaceuticals and bioactive compounds in cats

Das, S., & Ojha, P. K. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141274 · Cited by 2

A QSAR STUDY ON THIOUREA DERIVATIVES - NEW APPROACHES IN DRUG DEVELOPMENT

Roman, R. (2022) · FARMACIA · doi:10.31925/farmacia.2022.2.7 · Cited by 2

Essai n° 203: Poisson, essai de toxicité aiguë

OCDE (2009) · Lignes directrices de l'OCDE pour les essais de produits chimiques. Section 2: Effets sur les systèmes biologiques · doi:10.1787/9789264069978-fr · Cited by 2

Two‐step Multivariate Classification of the Mechanisms of Toxic Action of Phenols

Ren, S. (2003) · QSAR & Combinatorial Science · doi:10.1002/qsar.200330818 · Cited by 2

The toxicity of pulse-exposed insecticides and their mixtures to Melanotaenia fluviatilis and Daphnia carinata

Raymond, S. (2011) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27340557 · Cited by 2

U.S. EPA Document “A Framework for Ecological Risk Assessment”

(1998) · CRC Press eBooks · doi:10.1201/noe1566702652.axb · Cited by 2

Chemometric Modeling of Pesticide Aquatic Toxicity

Bora, A., & Funar‐Timofei, S. (2021) · doi:10.1002/9781119681397.ch19 · Cited by 2

The Effect of pH Value on Fertilized Eggs, Larva Fish and Juvenile Fish of Takifugu obscurusPreprint

Kong, X., He, F., & Li, H. (2023) · Preprints.org · doi:10.20944/preprints202303.0261.v1 · Cited by 2

A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

Udin, S. M., Maarof, H., & Rahman, N. A. (2023) · ChemistrySelect · doi:10.1002/slct.202301022 · Cited by 1

Fish acute toxicity syndromes and their use in the QSAR approach to hazard assessment. Environ. Health Perspect. 71

Mckim, J. M., Bradbury, S. P., & Niemit, G. J. (1987)

Predicting modes of toxic action from chemical structure: Acute toxicity in the fathead minnow ( Pimephales promelas )

Russom, C. L., Bradbury, S. P., Broderius, S. J., Hammermeister, D. E., & Drummond, R. A. (1997) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620160514 · Cited by 564

Study on the acute toxicity of chemicals to fish by QSAR model

Shen, S. (2011) · Xiandai huagong

Prediction of acute toxicity in fish by using QSAR methods and chemical modes of action

Lozano, S., Lescot, E., Halm‐Lemeille, M., Lepailleur, A., Bureau, R., & Rault, S. (2009) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756360903169857 · Cited by 18

Predicting modes of toxic action from chemical structure: Acute toxicity in the fathead minnow (Pimephales promelas). Environmental Toxicology and Chemistry 16

Russom, C. L., Bradbury, S. P., Broderius, S. J., Hammermeister, D. E., & Drummond, R. A. (1997)