The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of the differentiation of PC12 pheochromocytoma cells.
Open accessAbstract
The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla, has become a premiere model for the study of neuronal differentiation. When treated in culture with nanomolar concentrations of nerve growth factor, PC12 cells stop dividing, elaborate processes, become electrically excitable, and will make synapses with appropriate muscle cells in culture. The changes induced by nerve growth factor lead to cells that, by any number of criteria, resemble mature sympathetic neurons. These changes are accompanied by a series of biochemical alterations occurring in the membrane, the cytoplasm, and the nucleus of the cell. Some of these events are independent of changes in transcription, while others clearly involve changes in gene expression. A number of the alterations seen in the cells involve increases or decreases in the phosphorylation of key cellular proteins. The information available thus far allows the construction of a hypothesis regarding the biochemical basis of PC12 differentiation.
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Cites
Gene transfer and molecular cloning of the rat nerve growth factor receptor
Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., & Shooter, E. M. (1987) · Nature · doi:10.1038/325593a0 · Cited by 938
Gene Transfer and Molecular Cloning of the Human NGF Receptor
Chao, M. V., Bothwell, M. A., Ross, A. H., Koprowski, H., Lanahan, A. A., Buck, C. R., & Sehgal, A. (1986) · Science · doi:10.1126/science.3008331 · Cited by 449
Cited by
PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions
Wiatrak, B., Kubis-Kubiak, A., Piwowar, A., & Barg, E. (2020) · Cells · doi:10.3390/cells9040958 · Cited by 334
Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.
Lyons, W. E., George, E. B., Dawson, T. M., Steiner, J. P., & Snyder, S. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3191 · Cited by 285
Vetter, M. L., Martin-Zanca, D., Parada, L. F., Bishop, J. M., & Kaplan, D. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5650 · Cited by 270
Organic electrode coatings for next-generation neural interfaces
Aregueta-Robles, U. A., Woolley, A. J., Poole-Warren, L. A., Lovell, N. H., & Green, R. A. (2014) · Frontiers in Neuroengineering · doi:10.3389/fneng.2014.00015 · Cited by 254
Developmental Neurotoxicity of Perfluorinated Chemicals Modeled in Vitro
Slotkin, T. A., MacKillop, E. A., Melnick, R. L., Thayer, K. A., & Seidler, F. J. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11253 · Cited by 225
Metadata
- Authors
- Fujita, K., Lazarovici, P., & Guroff, G.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1989-03
- Volume
- 80
- Pages
- 127-142
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2031398528
- Cited by
- 309
- References
- 2
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- gold
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