The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water
Open accessAbstract
BACKGROUND: Neurotoxic effects are known to occur with inhalation of manganese particulates, but very few data are available on exposure to Mn in water. We undertook a pilot study in a community in Quebec (Canada) where naturally occurring high Mn levels were present in the public water system. Our objective was to test the hypothesis that greater exposure to Mn via drinking water would be reflected in higher Mn content in hair which, in turn, would be associated with increased level of hyperactive behaviors. METHODS: Forty-six children participated in the study, 24 boys and 22 girls, 6-15 years of age (median, 11 years). Their homes received water from one of two wells (W) with different Mn concentrations: WI: mean 610 microg/L; W2: mean 160 microg/L. The Revised Conners' Rating Scale for parents (CPRS-R) and for teachers (CTRS-R) were administered, providing T-scores on the following subscales: Oppositional, Hyperactivity, Cognitive Problems/Inattention, and ADHD Index. RESULTS: Children whose houses were supplied by WI had higher hair Mn (MnH) than those supplied by W2 (mean 6.2+/-4.7 microg/g vs. 3.3+/-3.0 microg/g, p = 0.025). MnH was significantly associated with T-scores on the CTRS-R Oppositional (p = 0.020) and Hyperactivity (p = 0.002) subscales, after adjustment for age, sex, and income. All children with Oppositional and Hyperactivity T-scores > 65 had MnH > 3.0 microg/g. CONCLUSIONS: The findings of this pilot study are sufficiently compelling to warrant more extensive investigations into the risks of Mn exposure in drinking water.
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Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
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Conners' rating scales-revised : technical manual
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Prevalence and Assessment of Attention-Deficit/Hyperactivity Disorder in Primary Care Settings
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Self-citationSachdev, H., Gera, T., & Nestel, P. (2005) · Public Health Nutrition · doi:10.1079/phn2004677 · Cited by 378
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Manganese Poisoning in Moroccan Miners
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Grandjean, P., & Landrigan, P. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70278-3 · Cited by 1,886
Peres, T. V., Schettinger, M. R. C., Chen, P., Carvalho, F., Avila, D. S., Bowman, A. B., & Aschner, M. (2016) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-016-0099-0 · Cited by 386
Early Postnatal Blood Manganese Levels and Children's Neurodevelopment
Claus Henn, B., Ettinger, A. S., Schwartz, J., Téllez-Rojo, M. M., Lamadrid-Figueroa, H., Hernández-Avila, M., Schnaas, L., Amarasiriwardena, C., Bellinger, D. C., Hu, H., et al. (2010) · Epidemiology · doi:10.1097/ede.0b013e3181df8e52 · Cited by 274
Self-citationMechanisms of lead and manganese neurotoxicity
Neal, A. P., & Guilarte, T. R. (2013) · Toxicology Research · doi:10.1039/c2tx20064c · Cited by 211
Manganese exposure: cognitive, motor and behavioral effects on children a review of recent findings
Zoni, S., & Lucchini, R. G. (2013) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32835e906b · Cited by 121
Metadata
- Authors
- Bouchard, M., Laforest, F., Vandelac, L., Bellinger, D., & Mergler, D.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-01
- Volume
- 115
- Issue
- 1
- Pages
- 122-127
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2003195563
- Cited by
- 422
- References
- 26
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bouchard, M., Laforest, F., Vandelac, L., Bellinger, D., & Mergler, D. (2007). Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water. Environmental Health Perspectives. https://doi.org/10.1289/ehp.9504
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