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Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study
Open accessAbstract
BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men's exposure is understudied. OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men. METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use. RESULTS: -value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66-156%) and hand/body lotion (79-147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254-1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant. CONCLUSIONS: We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374.
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Cites
Multiple imputation using chained equations: Issues and guidance for practice
White, I. R., Royston, P., & Wood, A. M. (2011) · Statistics in Medicine · doi:10.1002/sim.4067 · Cited by 9,792
Sterne, J. A. C., White, I. R., Carlin, J. B., Spratt, M., Royston, P., Kenward, M. G., Wood, A. M., & Carpenter, J. R. (2009) · BMJ · doi:10.1136/bmj.b2393 · Cited by 7,299
Estimation of Relationships for Limited Dependent Variables
Tobin, J. (1958) · Econometrica · doi:10.2307/1907382 · Cited by 6,996
Estimation of Average Concentration in the Presence of Nondetectable Values
Hornung, R. W., & Reed, L. D. (1990) · Applied Occupational and Environmental Hygiene · doi:10.1080/1047322x.1990.10389587 · Cited by 3,495
Carrico, C. K., Gennings, C., Wheeler, D. C., & Factor-Litvak, P. R. (2014) · Journal of Agricultural Biological and Environmental Statistics · doi:10.1007/s13253-014-0180-3 · Cited by 1,361
Epidemiologic evaluation of measurement data in the presence of detection limits
Lubin, J. H., Colt, J. S., Camann, D., Davis, S., Cerhan, J. R., Severson, R. K., Bernstein, L., & Hartge, P. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7199 · Cited by 1,021
Assessing exposure to phthalates – The human biomonitoring approach
Wittassek, M., Koch, H. M., Angerer, J., & Brüning, T. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000121 · Cited by 747
Guo, Y., & Kannan, K. (2013) · Environmental Science & Technology · doi:10.1021/es4042034 · Cited by 627
Zota, A. R., Calafat, A. M., & Woodruff, T. J. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1306681 · Cited by 585
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Dodson, R. E., NISHIOKA, M. G., Standley, L. J., Perovich, L. J., Brody, J. G., & Rudel, R. A. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104052 · Cited by 568
Possible endocrine disrupting effects of parabens and their metabolites
Boberg, J., Taxvig, C., Christiansen, S., & Hass, U. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.03.011 · Cited by 513
Phthalates and diet: a review of the food monitoring and epidemiology data
Serrano, S. E., Braun, J. M., Trasande, L., Dills, R. L., & Sathyanarayana, S. (2014) · Environmental Health · doi:10.1186/1476-069x-13-43 · Cited by 505
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O’Brien, K. M., Upson, K., Cook, N. R., & Weinberg, C. R. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509693 · Cited by 498
Urinary Concentrations of Four Parabens in the U.S. Population: NHANES 2005–2006
Calafat, A. M., Ye, X., Wong, L.-Y., Bishop, A. M., & Needham, L. L. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901560 · Cited by 452
Self-citationQuantification of 22 phthalate metabolites in human urine☆
SILVA, M., SAMANDAR, E., PREAUJR, J., REIDY, J., NEEDHAM, L., & CALAFAT, A. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.10.023 · Cited by 445
Self-citationKoch, H. M., Lorber, M., Christensen, K. L. Y., Pälmke, C., Koslitz, S., & Brüning, T. (2013) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2012.12.002 · Cited by 328
Personal Care Product Use Predicts Urinary Concentrations of Some Phthalate Monoesters
Duty, S. M., Ackerman, R. M., Calafat, A. M., & Hauser, R. B. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8083 · Cited by 308
Self-citationJanjua, N. R., Mortensen, G. K., Andersson, A.-M., Kongshoj, B., Niels E. Skakkebæk, A., & Wulf, H. C. (2007) · Environmental Science & Technology · doi:10.1021/es0628755 · Cited by 302
Braun, J. M., Just, A. C., Williams, P. L., Smith, K. W., Calafat, A. M., & Hauser, R. B. (2013) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2013.69 · Cited by 298
Self-citationUrinary excretion of phthalates and paraben after repeated whole‐body topical application in humans
Janjua, N. R., Frederiksen, H. W., Skakkebæk, N. E., Wulf, H. C., & Andersson, A. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00841.x · Cited by 277
Baby Care Products: Possible Sources of Infant Phthalate Exposure
Sathyanarayana, S., Karr, C. J., Lozano, P., Brown, E. R., Calafat, A. M., Liu, F., & Swan, S. H. (2008) · PEDIATRICS · doi:10.1542/peds.2006-3766 · Cited by 266
Self-citationZhou, X., Kramer, J. P., Calafat, A. M., & Ye, X. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.11.009 · Cited by 261
Self-citationKoch, H. M., Christensen, K. L. Y., Harth, V., Lorber, M., & Brüning, T. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0908-1 · Cited by 245
Harley, K. G., Kogut, K. R., Madrigal, D. S., Cardenas, M., Vera, I., Meza-Alfaro, G., She, J., Gavin, Q., Zahedi, R., Bradman, A., et al. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1510514 · Cited by 244
Smith, K. W., Braun, J. M., Williams, P. L., Ehrlich, S., Correia, K. F. B., Calafat, A. M., Ye, X., Ford, J. B., Keller, M. G., Meeker, J. D., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104614 · Cited by 219
Self-citationWeschler, C. J., Bekö, G., Koch, H. M., Salthammer, T., Schripp, T., Toftum, J., & Clausen, G. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409151 · Cited by 209
Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology
Calafat, A. M., Longnecker, M. P., Koch, H. M., Swan, S. H., Hauser, R. B., Goldman, L. R., Lanphear, B. P., Rudel, R. A., Engel, S. M., Teitelbaum, S. L., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1510041 · Cited by 179
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Romero-Franco, M., Hernández‐Ramírez, R. U., Calafat, A. M., Cebrián, M. E., Needham, L. L., Teitelbaum, S. L., Wolff, M. S., & López‐Carrillo, L. (2011) · Environment International · doi:10.1016/j.envint.2011.02.014 · Cited by 167
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Buckley, J. P., Weber, R. P., Matuszewski, J., Herring, A. H., Baird, D. D., Hartmann, K. E., & Hoppin, J. A. (2012) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2012.33 · Cited by 164
Moos, R. K., Angerer, J., Dierkes, G., Brüning, T., & Koch, H. M. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1636-0 · Cited by 158
Philippat, C., Bennett, D. H., Calafat, A. M., & Hertz‐Picciotto, I. (2015) · Environmental Research · doi:10.1016/j.envres.2015.04.009 · Cited by 151
Self-citationJust, A. C., Adibi, J. J., Rundle, A., Calafat, A. M., Camann, D., Hauser, R. B., Silva, M. J., & Whyatt, R. M. (2010) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2010.13 · Cited by 148
Self-citationLioy, P. J., Hauser, R. B., Gennings, C., Koch, H. M., Mirkes, P. E., Schwetz, B. A., & Kortenkamp, A. (2015) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2015.33 · Cited by 147
Self-citationA path forward in the debate over health impacts of endocrine disrupting chemicals
Zoeller, R. T., Bergman, Å., Becher, G., Bjerregaard, P., Bornman, R. M. S., Brandt, I., Iguchi, T., Jobling, S., Kidd, K. A., Kortenkamp, A., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-118 · Cited by 141
Orton, F., Ermler, S., Kugathas, S., Rosivatz, E., Scholze, M., & Kortenkamp, A. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.09.008 · Cited by 130
Howdeshell, K. L., Hotchkiss, A. K., & Gray, L. E. (2016) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2016.11.007 · Cited by 128
Koch, H. M., Aylward, L. L., Hays, S. M., Smolders, R., Moos, R. K., Cocker, J., Jones, K., Warren, N. D., Levy, L., & Bevan, R. J. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.06.023 · Cited by 120
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Christensen, K. L. Y., Carrico, C. K., Sanyal, A. J., & Gennings, C. (2013) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2013.01.005 · Cited by 104
Hannas, B. R., Lambright, C. S., Furr, J., Evans, N., Foster, P. M. D., Gray, L. E., & Wilson, V. S. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr315 · Cited by 99
Ferguson, K. K., Colacino, J. A., Lewis, R. C., & Meeker, J. D. (2016) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2016.27 · Cited by 97
Moos, R. K., Angerer, J., Wittsiepe, J., Wilhelm, M., Brüning, T., & Koch, H. M. (2014) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2014.06.003 · Cited by 94
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Martina, C. A., Weiss, B., & Swan, S. H. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.05.016 · Cited by 67
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Moos, R. K., Koch, H. M., Angerer, J., Apel, P., Schröter‐Kermani, C., Brüning, T., & Kolossa‐Gehring, M. (2015) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2015.07.005 · Cited by 66
Dodge, L. E., Williams, P. L., Williams, M. A., Missmer, S. A., Toth, T. L., Calafat, A. M., & Hauser, R. B. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408605 · Cited by 64
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Metadata
- Authors
- Nassan, F. L., Coull, B. A., Gaskins, A. J., Williams, M. A., Skakkebaek, N. E., Ford, J. B., Ye, X., Calafat, A. M., Braun, J. M., & Hauser, R.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Department of Growth and Reproduction & EDMaRC, Rigshospitalet University of Copenhagen, Copenhagen, Denmark
- Centers for Disease Control and Prevention (US)
- Brown University (US)
- Corresponding author
- Nassan, Feiby L.
- ORCID
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-08-16
- Volume
- 125
- Issue
- 8
- Pages
- 087012-087012
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC5783668
- OpenAlex
- W2750725786
- Cited by
- 101
- References
- 49
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 14 · 2022: 12 · 2021: 11 · 2020: 23 · 2019: 12 · 2018: 9 · 2017: 1
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nd)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- U.S. Department of Health and Human Services (R01 ES024381, P30ES000002, ES000002, ES009718)
- Harvard T.H. Chan School of Public Health (ES000002, P30 ES000002)
- National Institutes of Health (ES 000002)
- Centers for Disease Control and Prevention (R01 ES024381)
- National Institute of Environmental Health Sciences (R01ES009718, ES000002., ES009718, R01ES024381, P30ES000002, ES024381)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- personal care products, phthalate metabolites, parabens, methylparaben, propylparaben, butylparaben, urinary biomarkers, endocrine disruptors
- MeSH terms
- Adult, Cosmetics, Environmental Exposure, Humans, Male, Parabens, Phthalic Acids, Hazardous Substances
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