CoChat
Sign Up
Cited by 146Mercury impact and mitigation studiesHeavy Metal Exposure and ToxicityBlood Pressure and Hypertension Studies

Mercury exposure, blood pressure, and hypertension: A systematic review and dose–response meta-analysis

Open access
Hu, Xue Feng, Singh, Kavita, Chan, Hing Man·2018·Environmental Health Perspectives
DOI 10.1289/ehp2863PMC PMC6108832
Open this paper in CoChat — free accountOpen PDF

Abstract

Background: Body burden of mercury has been linked to hypertension in populations exposed to high mercury levels. Objectives: We summarized, extracted, and pooled the results of published studies that investigated mercury biomarkers and hypertension or blood pressure (BP) measurements to examine this potential relationship. Methods: We searched PubMed, Embase, and TOXLINE and selected studies according to a priori defined inclusion criteria. Study quality was assessed by the Newcastle-Ottawa scale for cohort and case–control studies and the Quality Assessment Tool for cross-sectional studies. Study estimates were pooled using inverse-variance weighted random-effects models. Dose–response meta-analysis was performed with studies reporting hypertension and systolic BP for at least three mercury categories. Results: A total of 29 studies were included in the meta-analysis. The pooled odds ratio (OR) for hypertension, comparing the highest and lowest mercury exposure categories, was 1.35 [95% confidence interval (CI): 0.99, 1.83] for populations with hair mercury ≥2μg/g in comparison with the OR of 1.12 (95% CI: 0.82, 1.52) for populations with hair mercury <2μg/g. Positive associations were also observed for highest versus lowest mercury exposure categories on systolic and diastolic BP. Heterogeneity was observed for mercury species and exposure groups across different studies. Associations estimated using different mercury biomarkers generally agree with each other in the same study. A nonlinear dose–response relationship with an inflection point at 3μg/g was identified, for both hypertension and systolic BP. Conclusions: A significant positive association between mercury and hypertension and between mercury and BP was identified. The exposure dose is an important factor in determining the toxic effects of mercury on hypertension. https://doi.org/10.1289/EHP2863

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1289/ehp2863

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 84

  1. Al-Saleh I, Shinwari N, Mashhour A, Mohamed GE-D, Ghosh MA, Shammasi Z, et al. 2006. Cadmium and mercury levels in Saudi women and its possible relationship with hypertension. Biol Trace Elem Res 112(1): 13– 29, PMID: 16943613, 10.1385/BTER:112:1:13. 16943613 · DOI
  2. Bartell SM, Ponce R. A, Sanga RN, Faustman EM 2000. Human variability in mercury toxicokinetics and steady state biomarker ratios. Environ Res 84(2): 127– 132, PMID: 11068925, 10.1006/enrs.2000.4104. 11068925 · DOI
  3. Bautista LE, Stein JH, Morgan BJ, Stanton N, Young T, Nieto FJ 2009. Association of blood and hair mercury with blood pressure and vascular reactivity. WMJ 108(5): 250– 252, PMID: 19743756, 10.1038/nbt.3121.ChIP-nexus. 19743756 PMC4593490 · DOI
  4. Berglund M, Lind B, Björnberg KA, Palm B, Einarsson Ö, Vahter M 2005. Inter-individual variations of human mercury exposure biomarkers: a cross-sectional assessment. Environ Health 4(1): 20, PMID: 16202128, 10.1186/1476-069X-4-20. 16202128 PMC1262739 · DOI
  5. Branco V, Caito S, Farina M, Teixeira da Rocha J, Aschner M, Carvalho C 2017. Biomarkers of mercury toxicity: past, present, and future trends. J Toxicol Environ Health B Crit Rev 20(3): 119– 154, PMID: 28379072, 10.1080/10937404.2017.1289834. 28379072 PMC6317349 · DOI
  6. Carmignani M, Boscolo P 1984. Cardiovascular homeostasis in rats chronically exposed to mercuric chloride. Arch Toxicol Suppl 7: 383– 388, PMID: 6596006. 6596006
  7. Carmignani M, Finelli V, Boscolo P 1983. Mechanisms in cardiovascular regulation following chronic exposure of male rats to inorganic mercury. Toxicol Appl Pharmacol 69(3): 442– 450, PMID: 6879611. 6879611
  8. Chan HM, Egeland G 2004. Fish consumption, mercury exposure, and heart diseases. Nutr Rev 62(2): 68– 72, PMID: 15080369, 10.1301/nr.2004.janr.68. 15080369 · DOI
  9. Choi AL, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Salonen JT, Tuomainen TP, et al. 2009. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect 117(3): 367– 372, PMID: 19337510, 10.1289/ehp.11608. 19337510 PMC2661905 · DOI
  10. Choi B, Yeum K-J, Park S-J, Kim K-N, Joo N-S 2015. Elevated serum ferritin and mercury concentrations are associated with hypertension; analysis of the fourth and fifth Korea national health and nutrition examination survey (KNHANES IV-2, 3, 2008–2009 and V-1, 2010). Environ Toxicol 30(1): 101– 108, PMID: 23929718, 10.1002/tox. 23929718 · DOI
  11. Clarkson TW, Magos L 2006. The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 36(8): 609– 662, PMID: 16973445, 10.1080/10408440600845619. 16973445 · DOI
  12. Crippa A, Orsini N 2016. Dose-response meta-analysis of differences in means. BMC Med Res Methodol 16: 91, PMID: 27485429, 10.1186/s12874-016-0189-0. 27485429 PMC4971698 · DOI
  13. Daneshmand R, Kurl S, Tuomainen T-P, Virtanen JK 2016. Associations of serum n-3 and n-6 PUFA and hair mercury with the risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). Br J Nutr 115(10): 1851– 1859, PMID: 26991769, 10.1017/S0007114516000982. 26991769 · DOI
  14. Dórea JG, De Souza JR, Rodrigues P, Ferrari Í, Barbosa AC 2005. Hair mercury (signature of fish consumption) and cardiovascular risk in Munduruku and Kayabi Indians of Amazonia. Environ Res 97(2): 209– 219, PMID: 15533337, 10.1016/j.envres.2004.04.007. 15533337 · DOI
  15. Driscoll CT, Mason RP, Chan HM, Jacob DJ, Pirrone N 2013. Mercury as a global pollutant: sources, pathways, and effects. Environ Sci Technol 47(10): 4967– 4983, PMID: 23590191, 10.1021/es305071v. 23590191 PMC3701261 · DOI
  16. Egger M, Smith GD, Sterne JAC 2001 Uses and abuses of meta-analysis. Clin Med (Lond) 1(6): 478– 484, 10.7861/clinmedicine.1-6-478. 11792089 PMC4953876 · DOI
  17. Eom S-Y, Choi S-H, Ahn S-J, Kim D-K, Kim D-W, Lim J-A, et al. 2014. Reference levels of blood mercury and association with metabolic syndrome in Korean adults. Int Arch Occup Environ Health 87(5): 501– 513, PMID: 23824410, 10.1007/s00420-013-0891-8. 23824410 · DOI
  18. Eum KD, Lee MS, Paek D 2008. Cadmium in blood and hypertension. Sci Total Environ 407(1): 147– 153, PMID: 18845316, 10.1016/j.scitotenv.2008.08.037. 18845316 · DOI
  19. Feng X, Li P, Qiu G, Wang S, Li G, Meng B, et al. 2008. Human exposure to methylmercury through rice intake in mercury mining areas, Guizhou Province, China. Environ Sci Technol 42(1): 326– 332, PMID: 18350916, 10.1021/es071948x. 18350916 · DOI
  20. Fillion M, Mergler D, Passos CJS, Larribe F, Lemire M, Guimarães JRD 2006. A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon. Environ Health 5: 29, PMID: 17032453, 10.1186/1476-069X-5-29. 17032453 PMC1617089 · DOI · Paper page
  21. Goodrich JM, Wang Y, Gillespie B, Werner R, Franzblau A, Basu N 2013. Methylmercury and elemental mercury differentially associate with blood pressure among dental professionals. Int J Hyg Environ Health 216(2): 195– 201, PMID: 22494934, 10.1016/j.ijheh.2012.03.001. 22494934 PMC3727420 · DOI
  22. Grandjean P, Murata K, Budtz-Jørgensen E, Weihe P 2004. Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort. J Pediatr 144(2): 169– 176, PMID: 14760255, 10.1016/j.jpeds.2003.10.058. 14760255 · DOI
  23. Guallar E, Sanz-Gallardo MI, van't Veer P, Bode P, Aro A, Gómez-Aracena J, et al. 2002. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med 347(22): 1747– 1754, PMID: 12456850, 10.1056/NEJMoa020157. 12456850 · DOI
  24. Ha E, Basu N, Bose-O'Reilly S, Dórea JG, McSorley E, Sakamoto M, et al. 2017. Current progress on understanding the impact of mercury on human health. Environ Res 152: 419– 433, PMID: 27444821, 10.1016/j.envres.2016.06.042. 27444821 · DOI
  25. Higgins JPT, Thompson SG 2002. Quantifying heterogeneity in a meta-analysis. Stat Med 21(11): 1539– 1558, PMID: 12111919, 10.1002/sim.1186. 12111919 · DOI · Paper page
  26. Hong D, Cho SH, Park SJ, Kim SY, Park SB 2013. Hair mercury level in smokers and its influence on blood pressure and lipid metabolism. Environ Toxicol Pharmacol 36(1): 103– 107, PMID: 23603462, 10.1016/j.etap.2013.03.007. 23603462 · DOI
  27. Houston MC 2011. Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. J Clin Hypertens (Greenwich) 13(8): 621– 627, PMID: 21806773, 10.1111/j.1751-7176.2011.00489.x. 21806773 PMC8108748 · DOI
  28. Hu XF, Eccles K, Chan HM 2017 High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada. Environ Int 102: 200– 206, 10.1016/j.envint.2017.03.002. 28279481 · DOI
  29. Johansson N, Basun H, Winblad B, Nordberg M 2002. Relationship between mercury concentration in blood, cognitive performance, and blood pressure, in an elderly urban population. Biometals 15: 189– 195, PMID: 12046928. 12046928
  30. Kalish BT, Rifas-Shiman SL, Wright RO, Amarasiriwardena CJ, Jayawardene I, Gillman MW, et al. 2014. Associations of prenatal maternal blood mercury concentrations with early and mid-childhood blood pressure: a prospective study. Environ Res 133: 327– 333, PMID: 25019468, 10.1016/j.envres.2014.06.004. 25019468 PMC4364915 · DOI
  31. Kobal AB, Horvat M, Prezelj M, Briški AS, Krsnik M, Dizdarevič T, et al. 2004. The impact of long-term past exposure to elemental mercury on antioxidative capacity and lipid peroxidation in mercury miners. J Trace Elem Med Biol 17(4): 261– 274, PMID: 15139389, 10.1016/S0946-672X(04)80028-2. 15139389 · DOI
  32. Kweon S, Kim Y, Jang M, Kim Y, Kim K, Choi S, et al. 2014. Data resource profile: the Korea National Health and Nutrition Examination Survey (KNHANES). Int J Epidemiol 43(1): 69– 77, PMID: 24585853, 10.1093/ije/dyt228. 24585853 PMC3937975 · DOI
  33. Laird BD, Goncharov AB, Egeland GM, Chan HM 2013. Dietary advice on Inuit traditional food use needs to balance benefits and risks of mercury, selenium, and n3 fatty acids 1–3. J Nutr 143(6): 923– 930, PMID: 23616502, 10.3945/jn.112.173351.923. 23616502 · DOI
  34. Lee B-K, Kim Y 2013. Blood cadmium, mercury, and lead and metabolic syndrome in South Korea: 2005–2010 Korean National Health and Nutrition Examination Survey. Am J Ind Med 56(6): 682– 692, PMID: 22911659, 10.1002/ajim.22107. 22911659 · DOI
  35. Lee B-K, Kim Y 2011. Relationship between blood manganese and blood pressure in the Korean general population according to KNHANES 2008. Environ Res 111(6): 797– 803, PMID: 21601843, 10.1016/j.envres.2011.05.005. 21601843 · DOI
  36. Lee JS, Kim J 2010. Vegetable intake in Korea: data from the Korean National Health and Nutrition Examination Survey 1998, 2001 and 2005. Br J Nutr 103(10): 1499– 1506, PMID: 20128936, 10.1017/S0007114509993527. 20128936 · DOI
  37. Liberda EN, Tsuji LJ, Martin ID, Ayotte P, Dewailly E, Nieboer E 2014. The complexity of hair/blood mercury concentration ratios and its implications. Environ Res 134: 286– 294, PMID: 25194499, 10.1016/j.envres.2014.08.007. 25194499 · DOI
  38. Liu Q, Cook NR, Bergström A, Hsieh CC 2009 A two-stage hierarchical regression model for meta-analysis of epidemiologic nonlinear dose–response data. Comput Stat Data Anal 53(12): 4157– 4167, 10.1016/j.csda.2009.05.001. · DOI
  39. Lorscheider FL, Vimy MJ, Summers AO 1995. Mercury exposure from “silver” tooth fillings: emerging evidence questions a traditional dental paradigm. FASEB J 9(7): 504– 508, PMID: 7737458. 7737458
  40. Magos L, Peristianis GC, Clarkson TW, Brown A, Preston S, Snowden RT 1981. Comparative study of the sensitivity of male and female rats to methylmercury. Arch Toxicol 48(1): 11– 20, PMID: 7283745. 7283745
  41. Malm O 1998. Gold mining as a source of mercury exposure in the Brazilian Amazon. Environ Res 77(2): 73– 78, PMID: 9600798, 10.1006/enrs.1998.3828. 9600798 · DOI · Paper page
  42. Mergler D, Anderson HA, Chan LHM, Mahaffey KR, Murray M, Sakamoto M, et al. 2007. Methylmercury exposure and health effects in humans: a worldwide concern. AMBIO 36(1): 3– 11, PMID: 17408186, 10.1579/0044-7447(2007)36[3:MEAHEI]2.0.CO;2. 17408186 · DOI
  43. Moher D, Liberati A, Tetzlaff J, Altman DG, et al. 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7): e1000097, PMID: 19621072, 10.1371/journal.pmed.1000097. 19621072 PMC2707599 · DOI · Paper page
  44. Mordukhovich I, Wright RO, Hu H, Amarasiriwardena C, Baccarelli A, Litonjua A, et al. 2012. Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the Normative Aging Study. Environ Health Perspect 120(1): 98– 104, PMID: 21878420, 10.1289/ehp.1002805. 21878420 PMC3261928 · DOI
  45. Mortensen ME, Caudill SP, Caldwell KL, Ward CD, Jones RL 2014. Total and methyl mercury in whole blood measured for the first time in the U.S. population: NHANES 2011–2012. Environ Res 134: 257– 264, PMID: 25173092, 10.1016/j.envres.2014.07.019. 25173092 PMC5584810 · DOI
  46. Mozaffarian D, Rimm EB 2006. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 296(15): 1885– 1900, PMID: 17047219, 10.1001/jama.296.15.1885. 17047219 · DOI · Paper page
  47. Mozaffarian D, Shi P, Morris JS, Grandjean P, Siscovick DS, Spiegelman D, et al. 2012. Mercury exposure and risk of hypertension in US men and women in 2 prospective cohorts. Hypertension 60(3): 645– 652, PMID: 22868395, 10.1161/HYPERTENSIONAHA.112.196154. 22868395 PMC3466587 · DOI · Paper page
  48. NRC (National Research Council). 2000 Toxicological Effects of Methylmercury. Washington, DC: The National Academies Press. 25077280
  49. Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ 2007. Lead exposure and cardiovascular disease - a systematic review. Environ Health Perspect 115(3): 472– 482, PMID: 17431501, 10.1289/ehp.9785. 17431501 PMC1849948 · DOI
  50. Nielsen ABS, Davidsen M, Bjerregaard P 2012. The association between blood pressure and whole blood methylmercury in a cross-sectional study among Inuit in Greenland. Environ Health 11(1): 44, PMID: 22747793, 10.1186/1476-069X-11-44. 22747793 PMC3403910 · DOI
  51. Ohno T, Sakamoto M, Kurosawa T, Dakeishi M, Iwata T, Murata K 2007. Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function. Environ Res 103(2): 191– 197, PMID: 16890218, 10.1016/j.envres.2006.06.009. 16890218 · DOI
  52. Oka T, Matsukura M, Okamoto M, Harada N, Kitano T, Miike T, et al. 2002. Autonomic nervous functions in fetal type Minamata disease patients: assessment of heart rate variability. Tohoku J Exp Med 198(4): 215– 221, PMID: 12630553, 10.1620/tjem.198.215. 12630553 · DOI
  53. Orsini N, Li R, Wolk A, Khudyakov P, Spiegelman D 2012. Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software. Am J Epidemiol 175(1): 66– 73, PMID: 22135359, 10.1093/aje/kwr265. 22135359 PMC3244608 · DOI
  54. Park S, Choi H-S, Bae J-H 2016. Instant noodles, processed food intake, and dietary pattern are associated with atopic dermatitis in an adult population (KNHANES 2009-2011.). Asia Pac J Clin Nutr 25: 602– 613, PMID: 27440696, 10.6133/apjcn.092015.23. 27440696 · DOI
  55. Park S, Choi N-K 2016. Associations of blood heavy metal levels with intraocular pressure. Ann Epidemiol 26(8): 546– 550, PMID: 27497680, 10.1016/j.annepidem.2016.07.002. 27497680 · DOI
  56. Park SK, Lee S, Basu N, Franzblau A 2013. Associations of blood and urinary mercury with hypertension in U.S. adults: the NHANES 2003-2006. Environ Res 123: 25– 32, PMID: 23472608, 10.1016/j.envres.2013.02.003. 23472608 PMC3644317 · DOI
  57. Pedersen EB, Jorgensen ME, Pedersen MB, Siggaard C, Sorensen TB, Mulvad G, et al. 2005. Relationship between mercury in blood and 24-h ambulatory blood pressure in Greenlanders and Danes. Am J Hypertens 18(5 Pt 1): 612– 618, PMID: 15882543, 10.1016/j.amjhyper.2004.11.022. 15882543 · DOI
  58. Perry HMJ, Erlanger MW 1974. Metal-induced hypertension following chronic feeding of low doses of cadmium and mercury. J Lab Clin Med 83(4): 541– 547, PMID: 4817779. 4817779
  59. Perry HM Jr, Erlanger M, Yunice A, Perry EF 1967. Mechanisms of the acute hypertensive effect of intra-arterial cadmium and mercury in anesthetized rats. J Lab Clin Med 70(6): 963– 972, PMID: 6059406, 10.5555/uri:pii:002221436790159X. 6059406 · DOI
  60. Rajaee M, Sánchez BN, Renne EP, Basu N 2015. An investigation of organic and inorganic mercury exposure and blood pressure in a small-scale gold mining community in Ghana. Int J Environ Res Public Health 12(8): 10020– 10038, PMID: 26308023, 10.3390/ijerph120810020. 26308023 PMC4555326 · DOI
  61. Roman HA, Walsh TL, Coull BA, Dewailly É, Guallar E, Hattis D, et al. 2011. Evaluation of the cardiovascular effects of methylmercury exposures: current evidence supports development of a dose–response function for regulatory benefits analysis. Environ Health Perspect 119(5): 607– 614, PMID: 21220222, 10.1289/ehp.1003012. 21220222 PMC3094409 · DOI
  62. Salonen JT, Seppanen K, Lakka TA, Salonen R, Kaplan GA 2000. Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland. Atherosclerosis 148(2): 265– 273, PMID: 10657561. 10657561
  63. Saudny H, Leggee D, Egeland G 2012. Design and methods of the Adult Inuit Health Survey 2007–2008. Int J Circumpolar Health 71(1): 19752– 19759, PMID: 23166895, 10.3402/ijch.v71i0.19752. 23166895 PMC3500824 · DOI
  64. Shiue I 2014. Higher urinary heavy metal, arsenic, and phthalate concentrations in people with high blood pressure: US NHANES, 2009–2010. Blood Press 23(6): 363– 369, PMID: 24945898, 10.3109/08037051.2014.925228. 24945898 · DOI
  65. Siblerud RL 1990. The relationship between mercury from dental amalgam and the cardiovascular system. Sci Total Environ 99(1–2): 23– 35, PMID: 2270468. 2270468
  66. Sørensen N, Murata K, Budtz-Jørgensen E, Weihe P, Grandjean P 1999. Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age. Epidemiology 10(4): 370– 375, PMID: 10401870. 10401870
  67. Sterne JAC, Jüni P, Schulz KF, Altman DG, Bartlett C, Egger M 2002. Statistical methods for assessing the influence of study characteristics on treatment effects in “meta-epidemiological” research. Stat Med 21(11): 1513– 1524, PMID: 12111917, 10.1002/sim.1184. 12111917 · DOI · Paper page
  68. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. 2000. Meta-analysis of observational studies in epidemiology - a proposal for reporting. JAMA 283(15): 2008– 2012, PMID: 10789670. 10789670
  69. Tamashiro H, Arakaki M, Akagi H, Hirayama K, Murao K, Smolensky MH 1986. Sex differential of methylmercury toxicity in spontaneously hypertensive rats (SHR). Bull Environ Contam Toxicol 37(6): 916– 924, PMID: 3790765, 10.1007/BF01607858. 3790765 · DOI
  70. Thomas DJ, Fisher HL, Hall LL, Mushak P 1982. Effects of age and sex on retention of mercury by methyl mercury-treated rats. Toxicol Appl Pharmacol 62(3): 445– 454, PMID: 7071859, 10.1016/0041-008X(82)90145-4. 7071859 · DOI
  71. Valera B, Dewailly E, Poirier P 2008 Cardiac autonomic activity and blood pressure among Nunavik Inuit adults exposed to environmental mercury: a cross-sectional study. Environ Health 7(1): 29, 10.1186/1476-069X-7-29. 18538022 PMC2443124 · DOI
  72. Valera B, Dewailly E, Poirier P 2011a. Impact of mercury exposure on blood pressure and cardiac autonomic activity among Cree adults (James Bay, Quebec, Canada). Environ Res 111(8): 1265– 1270, PMID: 21962568, 10.1016/j.envres.2011.09.001. 21962568 · DOI
  73. Valera B, Dewailly É, Poirier P 2013. Association between methylmercury and cardiovascular risk factors in a native population of Quebec (Canada): a retrospective evaluation. Environ Res 120: 102– 108, PMID: 22959488, 10.1016/j.envres.2012.08.002. 22959488 · DOI
  74. Valera B, Dewailly E, Poirier P 2009. Environmental mercury exposure and blood pressure among Nunavik Inuit adults. Hypertension 54(5): 981– 986, PMID: 19805642, 10.1161/HYPERTENSIONAHA.109.135046. 19805642 · DOI
  75. Valera B, Dewailly E, Poirier P, Counil E, Suhas E 2011b. Influence of mercury exposure on blood pressure, resting heart rate and heart rate variability in French Polynesians: a cross-sectional study. Environ Health 10(1): 99, PMID: 22078280, 10.1186/1476-069X-10-99. 22078280 PMC3228671 · DOI
  76. Virtanen JK, Laukkanen JA, Mursu J, Voutilainen S, Tuomainen T-P 2012a. Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. PLoS One 7(7): e41046, PMID: 22815906, 10.1371/journal.pone.0041046. 22815906 PMC3397970 · DOI · Paper page
  77. Virtanen JK, Nyantika AN, Kauhanen J, Voutilainen S, Tuomainen T-P 2012b. Serum long-chain n-3 polyunsaturated fatty acids, methylmercury and blood pressure in an older population. Hypertens Res 35(10): 1000– 1004, PMID: 22673531, 10.1038/hr.2012.80. 22673531 · DOI
  78. Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen T-P, Korhonen MJ, et al. 2005. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arterioscler Thromb Vasc Biol 25(1): 228– 233, PMID: 15539625, 10.1161/01.ATV.0000150040.20950.61. 15539625 · DOI
  79. Vupputuri S, Longnecker MP, Daniels JL, Guo X, Sandler DP 2005. Blood mercury level and blood pressure among US women: results from the National Health and Nutrition Examination Survey 1999-2000. Environ Res 97(2): 195– 200, PMID: 15533335, 10.1016/j.envres.2004.05.001. 15533335 · DOI
  80. Wakita Y 1987. Hypertension induced by methyl mercury in rats. Toxicol Appl Pharmacol 89(1): 144– 147, PMID: 3590186. 3590186
  81. Wells EM, Herbstman JB, Hong Y, Hibbeln JR, Halden RU, Witter FR, et al. 2017. Methyl mercury, but not inorganic mercury, associated with higher blood pressure during pregnancy. Environ. Res 154: 247– 252, PMID: 28110211, 10.1016/j.envres.2017.01.013. 28110211 PMC5328834 · DOI
  82. Wennberg M, Strömberg U, Bergdahl IA, Jansson JH, Kauhanen J, Norberg M, et al. 2012. Myocardial infarction in relation to mercury and fatty acids from fish: a risk-benefit analysis based on pooled Finnish and Swedish data in men. Am J Clin Nutr 96(4): 706– 713, PMID: 22894940, 10.3945/ajcn.111.033795.706. 22894940 · DOI
  83. Yorifuji T, Tsuda T, Kashima S, Takao S, Harada M 2010. Long-term exposure to methylmercury and its effects on hypertension in Minamata. Environ Res 110(1): 40– 46, PMID: 19922910, 10.1016/j.envres.2009.10.011. 19922910 · DOI
  84. Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh C-C, Spiegelman D, et al. 2002 Mercury and the risk of coronary heart disease in men. N Engl J Med 347(22): 1755– 1760, 10.1056/NEJMoa021437. 12456851 · DOI

Cited by

Sorted by citations

Authors
Hu, X. F., Singh, K., & Chan, H. M.
Affiliations
University of Ottawa (CA)
Corresponding author
Chan, Hing Man
ORCID
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
2018-07-01
Volume
126
Issue
7
Pages
076002-076002
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp2863
PMC
PMC6108832
OpenAlex
W2886397848
Cited by
146
References
3
Citations by year
2026: 6 · 2025: 15 · 2024: 17 · 2023: 22 · 2022: 24 · 2021: 30 · 2020: 23 · 2019: 8 · 2018: 1
FWCI
1.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Environmental Health Perspectives (publishedVersion, public-domain)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Government of Canada
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Mercury impact and mitigation studies
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
mercury exposure, hypertension, blood pressure, hair mercury, dose-response relationship, mercury toxicity, systolic blood pressure, diastolic blood pressure
MeSH terms
Blood Pressure, Dose-Response Relationship, Drug, Environmental Exposure, Environmental Pollutants, Humans, Hypertension, Mercury, Prevalence, Proportional Hazards Models, Odds Ratio

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review