The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Significance of Hyperuricemia on the Early Detection of Renal Failure in a Cohort of Screened Subjects.
Open accessAbstract
A high level of serum creatinine (S-Cr) is a predictor of end-stage renal disease (ESRD), but only a few studies have investigated the prevalence of high S-Cr and its correlates in a large population. We analyzed the data collected from 6,403 subjects (4,222 men and 2,181 women) who participated in the Okinawa General Health Maintenance Association (OGHMA) screening both at 1997 and 1999. The computer-saved data included sex, age, blood chemistries, blood pressure, medical histories, and lifestyles. Multivariate Cox proportional hazard analyses were performed to identify the correlates of developing high S-Cr levels: > or = 1.4 mg/dl in men and > or = 1.2 mg/dl in women. The prevalence of high S-Cr was 3.0% (N=193), which was 4.1% in men (N=175) and 0.8% in women (N=18), and increased with age in both sexes at the 1997 screening. Among those who showed normal levels of S-Cr in 1997 (N=6,210), 241 subjects (223 men and 18 women) developed high S-Cr. The 2-year cumulative incidence of high S-Cr was 5.5% in men and 0.8% in women. Other than sex, serum uric acid was the most significant correlate for developing high S-Cr. The adjusted relative risk (95% confidence interval) of those with serum uric acid 8.0 mg/dl and over was 2.91 (1.79-4.75) in men and 10.39 (1.91-56.62) in women when compared to those with serum uric acid less than 5.0 mg/dl. Prevalence of high levels of S-Cr was relatively high in men. Other than gender, serum uric acid was a significant positive correlate of developing high S-Cr in this sample of the Japanese population.
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Cites
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The Protective Effect of Moderate Alcohol Consumption on Ischemic Stroke
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Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients
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Cited by
Johnson, R. J., Segal, M. S., Sautin, Y., Nakagawa, T., Feig, D. I., Kang, D.-H., Gersch, M. S., Benner, S., & Sánchez-Lozada, L. G. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.899 · Cited by 1,075
Siu, Y.-P., Leung, K.-T., Tong, M. K.-H., & Kwan, T.-H. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.10.006 · Cited by 834
Uric Acid and Incident Kidney Disease in the Community
Weiner, D. E., Tighiouart, H., Elsayed, E. F., Griffith, J. L., Salem, D. N., & Levey, A. S. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007101075 · Cited by 462
Uric acid, hyperuricemia and vascular diseases
Jin, M. (2012) · Frontiers in Bioscience · doi:10.2741/3950 · Cited by 406
Metabolomic Analysis of Livers and Serum from High-Fat Diet Induced Obese Mice
Kim, H.-J., Kim, J. H., Noh, S., Hur, H. J., Sung, M. J., Hwang, J.-T., Park, J. H., Yang, H. J., Kim, M.-S., Kwon, D. Y., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr100892r · Cited by 376
Metadata
- Authors
- ISEKI, K., OSHIRO, S., TOZAWA, M., ISEKI, C., IKEMIYA, Y., & TAKISHITA, S.
- Venue
- Hypertension Research
- Publisher
- Japanese Society of Hypertension
- Published
- 2001
- Volume
- 24
- Issue
- 6
- Pages
- 691-697
- ISSN
- 0916-9636 (ISSN-L)
- OpenAlex
- W2048113580
- Cited by
- 386
- References
- 27
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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