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Cited by 441

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients

Open access
Alderman, Michael H., Cohen, Hillel, Madhavan, Shantha, Kivlighn, Salah·1999·Hypertension
DOI 10.1161/01.hyp.34.1.144
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Abstract

Abstract —To determine whether pretreatment and/or in-treatment serum uric acid (SUA) is independently and specifically associated with cardiovascular events in hypertensive patients, we examined the 20-year experience of 7978 mild-to-moderate hypertensive participants in a systematic worksite treatment program. Clinical evaluation and treatment were protocol-directed. SUA was measured at entry and annually thereafter. Subjects were stratified according to gender-specific quartile of baseline SUA. Blood pressures at entry and in-treatment were, respectively, 152.5/95.6 and 138.9/85.4 mm Hg. SUA was normally distributed with a mean of 0.399±0.0893 and 0.321±0.0833 mmol/L for men and women, respectively. Subjects with highest SUA were heavier, had greater evidence of cardiovascular disease (CVD), higher systolic blood pressure, higher creatinine, more frequent diuretic use, and lower prevalence of diabetes. During an average follow-up of 6.6 years (52 751 patient-years), 548 CVD events (183 mortal) and 116 non-CVD events occurred. In bivariate analysis, the association of SUA to CVD was more robust in nonwhites than whites and in patients at low versus high CVD risk. In multivariate analysis, CVD incidence was significantly associated with SUA with a hazard ratio of 1.22 (95% confidence interval 1.11 to 1.35), controlling for other known cardiovascular risk factors, including serum creatinine, body mass index, and diuretic use. Despite blood pressure control, SUA levels increased during treatment and were significantly and directly associated with CVD events, independently of diuretic use and other cardiovascular risk factors.

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Metadata

Authors
Alderman, M. H., Cohen, H., Madhavan, S., & Kivlighn, S.
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-07
Volume
34
Issue
1
Pages
144-150
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.34.1.144
OpenAlex
W1997145262
Cited by
441
References
22
FWCI
12.86
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients. https://app.cochat.ai/papers/10.1161/01.hyp.34.1.144
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Alderman, M. H., Cohen, H., Madhavan, S., & Kivlighn, S. (1999). Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients. Hypertension. https://doi.org/10.1161/01.hyp.34.1.144

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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