Enhancement of resistance to bacterial infection in mice by vitamin B2
Open accessAbstract
We found that the intramuscular injection of vitamin B2 enhanced host resistance to E. coli infection in a dose-dependent manner (6.25 mg/kg-100 mg/kg). Furthermore, VB2 exhibited the protective activity against Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Actinobacillus pleuropneumoniae. The mechanism of action of VB2 for enhancing resistance in mice may be, at least in part, its ability to stimulate the multiplication of neutrophils and monocytes, and to activate macrophages.
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The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.
“The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.59, 60, 61, 62, 63,64”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [62]
Microbial metabolites produced in the gut directly interact with intestinal epithelial cells and immune cells and impact host health.
“Microbial metabolites produced in the gut directly interact with IECs and immune cells and impact host health.61,62”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [62]
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Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
Effects of metabolites derived from gut microbiota and hosts on pathogens
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- Authors
- ARAKI, S., SUZUKI, M., FUJIMOTO, M., & KIMURA, M.
- Affiliations
- Eisai (Japan) (JP)
- ORCID
- KIMURA, Makoto
- Venue
- Journal of Veterinary Medical Science
- Published
- 1995
- Volume
- 57
- Issue
- 4
- Pages
- 599-602
- ISSN
- 0916-7250 (ISSN-L)
- 1347-7439
- OpenAlex
- W2313415952
- Cited by
- 45
- References
- 18
- Citations by year
- 2026: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Veterinary Medical Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- riboflavin, bacterial infection resistance, host defense, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Actinobacillus pleuropneumoniae, neutrophils, monocytes, macrophage activation, dose-dependent effects, mice
- MeSH terms
- Actinobacillus Infections, Animals, Bacterial Infections, Escherichia coli Infections, Immunity, Innate, Injections, Intramuscular, Klebsiella Infections, Klebsiella pneumoniae, Leukocyte Count, Male, Mice, Inbred ICR, Mice, Inbred Strains, Phagocytosis, Pseudomonas aeruginosa, Pseudomonas Infections, Riboflavin, Staphylococcal Infections, Staphylococcus aureus, Actinobacillus pleuropneumoniae, Macrophages, Peritoneal, Mice
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