Effects of metabolites derived from gut microbiota and hosts on pathogens
Open accessAbstract
Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, amino acids and vitamins, the metabolites derived from gut microbiota are also essential for intestinal homeostasis. In addition, some metabolites are only generated and released by gut microbiota, such as bacteriocins, short-chain fatty acids, and quorum-sensing autoinducers. In this review, we summarize recent studies regarding the crosstalk between pathogens and metabolites from different sources, including the influence on bacterial development and the activation/inhibition of immune responses of hosts. All of these functions would affect the colonization of and infection by pathogens. This review provides clear ideas and directions for further exploring the regulatory mechanisms and effects of metabolites on pathogens.
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The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.
“The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.59, 60, 61, 62, 63,64”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [61]
Microbial metabolites produced in the gut directly interact with intestinal epithelial cells and immune cells and impact host health.
“Microbial metabolites produced in the gut directly interact with IECs and immune cells and impact host health.61,62”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [61]
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Regulation of Intestinal Barrier Function by Microbial Metabolites
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- Authors
- Li, Z., Quan, G., Jiang, X., Yang, Y., Ding, X., Zhang, D., Wang, X., Hardwidge, P. R., Ren, W., & Zhu, G.
- Affiliations
- Yangzhou University (CN)
- Kansas State University (US)
- South China Agricultural University (CN)
- Corresponding author
- Ren, Wenkai
- Zhu, Guoqiang
- ORCID
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2018-09-14
- Volume
- 8
- Pages
- 314-314
- ISSN
- 2235-2988 (ISSN-L)
- PMC
- PMC6152485
- OpenAlex
- W2891444379
- Cited by
- 157
- References
- 135
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 20 · 2023: 16 · 2022: 24 · 2021: 35 · 2020: 25 · 2019: 10
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31270171, 30771603, 31072136, 31672579, 2016YFD0500905, YZ2018154, 30571374)
- YangZhou Science and Technology Bureau
- National Key Research and Development Program of China (2017YFD 0500105, 30771603, 30571374, 31672579, YZ2018154, 31270171, 2016YFD0500905)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota metabolites, host metabolites, intestinal metabolites, short-chain fatty acids, bacteriocins, free fatty acids, amino acids, vitamins, host immunity, intestinal homeostasis, bacterial colonization, host-pathogen interaction
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Bacterial Infections, Biological Factors, Body Fluids, Humans, Intestines, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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