Cited by 157Gut microbiota and healthAnimal Nutrition and PhysiologyProbiotics and Fermented Foods

Effects of metabolites derived from gut microbiota and hosts on pathogens

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Li, Zhendong, Quan, Guomei, Jiang, Xinyi, Yang, Yang, Ding, Xueyan, Zhang, Dong, Wang, Xiuqing, Hardwidge, Philip R. +2 more·2018·Frontiers in Cellular and Infection Microbiology

Abstract

Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, amino acids and vitamins, the metabolites derived from gut microbiota are also essential for intestinal homeostasis. In addition, some metabolites are only generated and released by gut microbiota, such as bacteriocins, short-chain fatty acids, and quorum-sensing autoinducers. In this review, we summarize recent studies regarding the crosstalk between pathogens and metabolites from different sources, including the influence on bacterial development and the activation/inhibition of immune responses of hosts. All of these functions would affect the colonization of and infection by pathogens. This review provides clear ideas and directions for further exploring the regulatory mechanisms and effects of metabolites on pathogens.

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Crossref · 10.3389/fcimb.2018.00314

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  • The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.

    “The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.59, 60, 61, 62, 63,64”
  • Microbial metabolites produced in the gut directly interact with intestinal epithelial cells and immune cells and impact host health.

    “Microbial metabolites produced in the gut directly interact with IECs and immune cells and impact host health.61,62”

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Authors
Li, Z., Quan, G., Jiang, X., Yang, Y., Ding, X., Zhang, D., Wang, X., Hardwidge, P. R., Ren, W., & Zhu, G.
Affiliations
  • Yangzhou University (CN)
  • Kansas State University (US)
  • South China Agricultural University (CN)
Corresponding author
  • Ren, Wenkai
  • Zhu, Guoqiang
Venue
Frontiers in Cellular and Infection Microbiology
Published
2018-09-14
Volume
8
Pages
314-314
ISSN
2235-2988 (ISSN-L)
OpenAlex
W2891444379
Cited by
157
References
135
Citations by year
2026: 9 · 2025: 18 · 2024: 20 · 2023: 16 · 2022: 24 · 2021: 35 · 2020: 25 · 2019: 10
FWCI
1.71
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (31270171, 30771603, 31072136, 31672579, 2016YFD0500905, YZ2018154, 30571374)
  • YangZhou Science and Technology Bureau
  • National Key Research and Development Program of China (2017YFD 0500105, 30771603, 30571374, 31672579, YZ2018154, 31270171, 2016YFD0500905)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota metabolites, host metabolites, intestinal metabolites, short-chain fatty acids, bacteriocins, free fatty acids, amino acids, vitamins, host immunity, intestinal homeostasis, bacterial colonization, host-pathogen interaction
MeSH terms
Gastrointestinal Microbiome, Animals, Bacteria, Bacterial Infections, Biological Factors, Body Fluids, Humans, Intestines, Host-Pathogen Interactions

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