Role of macrophages in normal wound healing: an overview
Abstract
Macrophages play an essential role during inflammation in normal wound healing. They promote the recruitment and proliferation of fibroblasts, and express some of the key growth factors that stimulate angiogenesis.
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By 48-72 h post-injury, macrophages dominate the cell population at injury site.
“By 48–72 h post-injury, however, macrophages begin to dominate the cell population at the site of injury [93].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [93]
Macrophages are recognized as the most long-lived and central cell population in dermal wound healing, largely through production of cytokines, growth factors, and MMPs.
“Macrophages, however, have been recognized as the most long-lived and central cell population that plays a role in dermal wound healing largely through the production of the cytokines, growth factors, and MMPs described above [93,103,104].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [93]
Cites
Inflammatory cells during wound repair: the good, the bad and the ugly
Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340 · see citing works
Accelerated wound closure in neutrophil-depleted mice
Dovi, J. V., He, L.-K., & DiPietro, L. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802406 · Cited by 525 · see citing works
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Brown, B. N., Ratner, B. D., Goodman, S. B., Amar, S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.034 · Cited by 926 · see citing works
“Macrophages, however, have been recognized as the most long-lived and central cell population that plays a role in dermal wound healing largely through the production of the cytokines, growth factors, and MMPs described above [93,103,104].”
BackgroundBrown, B. N., Londono, R., Tottey, S., Zhang, L., Kukla, K. A., Wolf, M. T., Daly, K. A., Reing, J. E., & Badylak, S. F. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.11.031 · Cited by 745 · see citing works
Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers
Klopfleisch, R. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.003 · Cited by 298 · see citing works
The neglected role of copper ions in wound healing
Kornblatt, A. P., Nicoletti, V. G., & Travaglia, A. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.02.012 · Cited by 221 · see citing works
- Authors
- Adamson, R.
- Affiliations
- Gloucestershire Primary Care Trust, UK.
- Corresponding author
- Adamson, R.
- Venue
- Journal of Wound Care
- Publisher
- Mark Allen Group
- Published
- 2009-08
- Volume
- 18
- Issue
- 8
- Pages
- 349-351
- ISSN
- 0969-0700 (ISSN-L)
- 2052-2916
- OpenAlex
- W2323233305
- Cited by
- 104
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 13 · 2016: 14 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 14
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Wound Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- macrophages, wound healing, inflammation, fibroblast recruitment, fibroblast proliferation, angiogenesis, growth factors
- MeSH terms
- Animals, Debridement, Disease Models, Animal, Fibroblasts, Guinea Pigs, Humans, Inflammation, Macrophages, Neutrophils, Wound Healing, Wounds and Injuries, Skin Care, Neovascularization, Physiologic, Intercellular Signaling Peptides and Proteins, Mice, Rats
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