Cited by 525Wound Healing and TreatmentsNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathways

Accelerated wound closure in neutrophil-depleted mice

Dovi, Julia V, He, Li-Ke, DiPietro, Luisa A·2003·Journal of Leukocyte Biology

Abstract

The infiltration of neutrophils into injured tissue is known to protect wounds from invading pathogens. However, more recent studies suggest that neutrophils might inhibit the wound repair process. To investigate the role of neutrophils in wounds, mice were neutrophil-depleted by injection with rabbit anti-mouse neutrophil serum. Remarkably, epidermal healing, measured by wound closure, proceeded significantly faster in neutropenic than control mice (77.7+14.2% vs. 41.2+0.9%, P<0.02 at day 2). Dermal healing was not affected by neutrophil depletion, as neither collagen deposition nor wound-breaking strength was significantly different between neutropenic and control mice. As the delayed repair of diabetic individuals exhibits robust inflammation, the effect of neutrophil depletion on diabetic wound healing was investigated. Similar to the observations in wild-type mice, wound closure was accelerated by nearly 50% in neutropenic, diabetic mice. The results suggest that although neutrophils may provide protection against infection, they may retard wound closure.

Integrity signals

Registry

Crossref · 10.1189/jlb.0802406

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Mice depleted of neutrophils using a rabbit antineutrophil serum show faster wound healing than controls.

    “By contrast with the CXCR2−/− mice, mice depleted of neutrophils using a rabbit antineutrophil serum show faster wound healing than controls.50”

    From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [50]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Dovi, J. V., He, L.-K., & DiPietro, L. A.
Affiliations
Loyola University Medical Center (US)
Corresponding author
DiPietro, Luisa A
Venue
Journal of Leukocyte Biology
Published
2003-04-01
Volume
73
Issue
4
Pages
448-455
ISSN
  • 0741-5400 (ISSN-L)
  • 1938-3673
OpenAlex
W2163105501
Cited by
525
References
28
Citations by year
2026: 6 · 2025: 16 · 2024: 16 · 2023: 28 · 2022: 26 · 2021: 26 · 2020: 22 · 2019: 32 · 2018: 30 · 2017: 39 · 2016: 30 · 2015: 28 · 2014: 33 · 2013: 26 · 2012: 22
FWCI
13.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Leukocyte Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
neutrophils, wound healing, neutrophil depletion, skin wound healing, collagen deposition, wound tensile strength, diabetic wound healing, inflammation
MeSH terms
Animals, Collagen, Diabetes Mellitus, Epithelial Cells, Female, Flow Cytometry, Macrophages, Mice, Inbred BALB C, Mice, Inbred C57BL, Peroxidase, Neutropenia, Neutrophils, Rabbits, Skin, Wound Healing, Wounds and Injuries, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review