Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers
Abstract
Unlabelled The foreign body reaction (FBR) is a response of the host tissue against more or less degradation-resistant foreign macromolecular material. The reaction is divided into five different phases which involve most aspects of the innate and the adaptive immune system: protein adsorption, acute and chronic inflammation, foreign body giant cell formation and fibrosis. It is long known, that macrophages play a central role in all of these phases except for protein adsorption. Initially it was believed that the macrophage driven FBR has a complete negative effect on biocompatibility. Recent progress in biomaterial and macrophage research however describe macrophages as more than pure antigen phagocytosing and presenting cells and thus pro-inflammatory cells involved in biomaterial encapsulation and failure. Quite contrary, both, pro-inflammatory M1 macrophages, the diverse regulatory M2 macrophage subtypes and even foreign body giant cells (FBGC) are after necessary for integration of non-degradable biomaterials and degradation and replacement of degradable biomaterials. This review gives a comprehensive overview on the taxonomy of the currently known macrophage subtypes. Their diverging functions, metabolism and markers are summarized and the relevance of this more diverse macrophage picture for the design of biomaterials is shortly discussed.Statement of significance The view on role of macrophages in the foreign body reaction against biomaterials is rapidly changing. Despite the initial idea that macrophage are mainly involved in undesired degradation and biomaterial rejection it becomes now clear that they are nevertheless necessary for proper integration of non-degradable biomaterials and degradation of placeholder, degradable biomaterials. As a pathologist I experienced a lack on a good summary on the current taxonomy, functions and phenotypes of macrophages in my recent projects on the biocompatibility of biomaterials in the mouse model. The submitted review therefore intends to gives a comprehensive overview on the taxonomy of the currently known macrophage subtypes. Their diverging functions, metabolism and markers are summarized and the relevance of this more diverse macrophage picture for the design of biomaterials is shortly discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Within a few days, attracted macrophages, mostly M1, form foreign body giant cells, which release potent enzymes and accelerate graft degradation.
“Within a few days, attracted macrophages, mostly from inflammatory phenotype (M1 macrophages), form foreign body giant cells, which release potent enzymes and accelerate graft degradation [23].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [23]
M2 macrophages decrease inflammatory activity by releasing anti-inflammatory cytokines such as IL-10.
“M2 macrophages decrease inflammatory activity by releasing anti-inflammatory cytokines such as IL-10 (Klopfleisch, 2016).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Klopfleisch, 2016
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542 · see citing works
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · see citing works
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · see citing works
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138 · see citing works
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689 · see citing works
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · see citing works
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541 · see citing works
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · see citing works
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160 · see citing works
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570 · see citing works
Martínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,336 · see citing works
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067 · see citing works
Jha, A. K., Huang, S. C.-C., Sergushichev, A., Lampropoulou, V., Ivanova, Y., Loginicheva, E., Chmielewski, K., Stewart, K. M., Ashall, J., Everts, B., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.005 · Cited by 2,066 · see citing works
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002 · see citing works
the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972 · see citing works
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
Kelly, B., & O'Neill, L. A. (2015) · Cell Research · doi:10.1038/cr.2015.68 · Cited by 1,876 · see citing works
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840 · see citing works
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
Rőszer, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/816460 · Cited by 1,762 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES
van Furth, R., & Cohn, Z. A. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.3.415 · Cited by 1,564 · see citing works
Inflammatory processes in muscle injury and repair.
Tidball, J. (2005) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00454.2004 · Cited by 1,392 · see citing works
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
Krausgruber, T., Blazek, K. D., Smallie, T., Alzabin, S., Lockstone, H. E., Sahgal, N., Hussell, T., Feldmann, M., & Udalova, I. A. (2011) · Nature Immunology · doi:10.1038/ni.1990 · Cited by 1,296 · see citing works
Quintin, J., Saeed, S., Martens, J. H. A., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., Jacobs, L., Jansen, T., Kullberg, B.-J., Wijmenga, C., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.06.006 · Cited by 1,289 · see citing works
Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages
Rath, M., ller, I. M. ⁄., Kropf, P., Closs, E. I., & Munder, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00532 · Cited by 1,271 · see citing works
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · see citing works
Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100 · see citing works
Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055 · see citing works
Macrophages in Tumor Microenvironments and the Progression of Tumors
Hao, N.-B., Lü, M.-H., Fan, Y.-H., Cao, Y.-L., Zhang, Z.-R., & Yang, S.-M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/948098 · Cited by 1,003 · see citing works
The role of macrophage phenotype in vascularization of tissue engineering scaffolds
Spiller, K. L., Anfang, R. R., Spiller, K. J., Ng, J., Nakazawa, K. R., Daulton, J. W., & Vunjak-Novakovic, G. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.012 · Cited by 948 · see citing works
Bain, C. C., Scott, C. L., Uronen‐Hansson, H., Guðjónsson, S., Jansson, O., Grip, O., Guilliams, M., MALISSEN, B., Agace, W. W., & Mowat, A. M. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.89 · Cited by 947 · see citing works
Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials · doi:10.1038/nmat4290 · Cited by 897 · see citing works
Brown, B. N., Valentin, J. E., Stewart-Akers, A. M., McCabe, G. P., & Badylak, S. F. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.11.040 · Cited by 896 · see citing works
Biochemical and functional characterization of three activated macrophage populations
Edwards, J. P., Zhang, X., Frauwirth, K. A., & Mosser, D. M. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0406249 · Cited by 863 · see citing works
MicroRNAs: the fine-tuners of Toll-like receptor signalling
O'Neill, L. A. J., Sheedy, F. J., & McCoy, C. E. (2011) · Nature reviews. Immunology · doi:10.1038/nri2957 · Cited by 851 · see citing works
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816 · see citing works
Hoeffel, G., Wang, Y., Greter, M., See, P., Teo, P., Malleret, B., Leboeuf, M., Low, D., Oller, G., Almeida, F., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120340 · Cited by 786 · see citing works
Human macrophage activation programs induced by bacterial pathogens
Nau, G., Richmond, J., Schlesinger, A., Jennings, E., Lander, E., & Young, R. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.022649799 · Cited by 781 · see citing works
Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal
Carlin, L. M., Stamatiades, E. G., Auffray, C., Hanna, R. N., Glover, L., Vizcay‐Barrena, G., Hedrick, C. C., Cook, H. T., Diebold, S. S., & Geissmann, F. (2013) · Cell · doi:10.1016/j.cell.2013.03.010 · Cited by 764 · see citing works
Brown, B. N., Londono, R., Tottey, S., Zhang, L., Kukla, K. A., Wolf, M. T., Daly, K. A., Reing, J. E., & Badylak, S. F. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.11.031 · Cited by 745 · see citing works
Comparison of gene expression profiles between human and mouse monocyte subsets
Ingersoll, M. A., Spanbroek, R., Lottaz, C., Gautier, E. L., Frankenberger, M., Hoffmann, R. F. G., Lang, R., Haniffa, M. A., Collin, M. P., Tacke, F., et al. (2009) · Blood · doi:10.1182/blood-2009-07-235028 · Cited by 731 · see citing works
Macrophage Phenotype as a Determinant of Biologic Scaffold Remodeling
Badylak, S. F., Valentin, J. E., Ravindra, A. K., McCabe, G. P., & Stewart-Akers, A. M. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0264 · Cited by 729 · see citing works
Dyken, S. J. V., & Locksley, R. M. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095906 · Cited by 714 · see citing works
Titanium surface characteristics, including topography and wettability, alter macrophage activation
Hotchkiss, K. M., Reddy, G. B., Hyzy, S. L., Schwartz, Z., Boyan, B. D., & Olivares‐Navarrete, R. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.12.003 · Cited by 686 · see citing works
Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages
Chávez‐Galán, L., Olleros, M. L., Vesin, D., & Garcia, I. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00263 · Cited by 653 · see citing works
Consequences of ineffective decellularization of biologic scaffolds on the host response
Keane, T. J., Londono, R., Turner, N. J., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.054 · Cited by 613 · see citing works
Bazzoni, F., Rossato, M., Fabbri, M., Gaudiosi, D., Mirolo, M., Mori, L., Tamassia, N., Mantovani, A., Cassatella, M. A., & Locati, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810909106 · Cited by 548 · see citing works
Defining GM-CSF– and Macrophage-CSF–Dependent Macrophage Responses by In Vitro Models
Lacey, D. C., Achuthan, A. A., Fleetwood, A. J., Dinh, H., Roiniotis, J., Scholz, G. M., Chang, M. W., Beckman, S. K., Cook, A. D., & Hamilton, J. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103426 · Cited by 529 · see citing works
Henson, P. M. (1971) · PubMed · Cited by 514 · see citing works
Wound Macrophages as Key Regulators of Repair
Brancato, S. K., & Albina, J. E. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.08.003 · Cited by 508 · see citing works
Macrophages During the Fibrotic Process: M2 as Friend and Foe
Braga, T. T., Agudelo, J. S. H., & Câmara, N. O. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00602 · Cited by 462 · see citing works
Garg, K., Pullen, N. A., Oskeritzian, C. A., Ryan, J. J., & Bowlin, G. L. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.065 · Cited by 457 · see citing works
Ontogeny of the Hematopoietic System
Cumano, A., & Godin, I. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141538 · Cited by 432 · see citing works
Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor‐κΒ
LANGEN, R. C. J., Schols, A. M. W. J., KELDERS, M. C. J. M., Wouters, E. F. �., & Janssen-Heininger, Y. M. W. (2001) · The FASEB Journal · doi:10.1096/fj.00-0463 · Cited by 423 · see citing works
Belkina, A. C., Nikolajczyk, B. S., & Denis, G. V. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202838 · Cited by 421 · see citing works
EXTRACELLULAR MATRIX BIOSCAFFOLDS FOR ORTHOPAEDIC APPLICATIONS
Valentin, J. E., Badylak, J. S., McCabe, G. P., & Badylak, S. F. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.e.01008 · Cited by 410 · see citing works
Ferrante, C. J., Pinhal-Enfield, G., Elson, G., Cronstein, B. N., Hasko, G., Outram, S., & Leibovich, S. J. (2013) · Inflammation · doi:10.1007/s10753-013-9621-3 · Cited by 375 · see citing works
Tidball, J. G., & Wehling‐Henricks, M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.118265 · Cited by 375 · see citing works
Ifrim, D. C., Quintin, J., Joosten, L. A. B., Jacobs, C. W. M., Jansen, T., Jacobs, L., Gow, N. A. R., Williams, D. L., van der Meer, J. W. M., & Netea, M. G. (2014) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00688-13 · Cited by 358 · see citing works
The Immunologic Release of Constituents from Neutrophil Leukocytes
Henson, P. M. (1971) · The Journal of Immunology · doi:10.4049/jimmunol.107.6.1535 · Cited by 347 · see citing works
Chen, Z., Wu, C., Gu, W., Klein, T. J., Crawford, R., & Xiao, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.014 · Cited by 324 · see citing works
OsteoMacs: Key players around bone biomaterials
Miron, R. J., & Bosshardt, D. D. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.017 · Cited by 321 · see citing works
Ma, Q.-L., Zhao, L.-Z., Liu, R.-R., Jin, B.-Q., Song, W., Wang, Y., Zhang, Y.-S., Chen, L.-H., & Zhang, Y.-M. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.025 · Cited by 319 · see citing works
Molecular and epigenetic basis of macrophage polarized activation
Porta, C., Riboldi, E., Ippolito, A., & Sica, A. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.003 · Cited by 319 · see citing works
Zhao, Q., Topham, N., Anderson, J. M., Hiltner, A., Lodoen, G., & Payet, C. R. (1991) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820250205 · Cited by 318 · see citing works
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation
Mullican, S. E., Gaddis, C. A., Alenghat, T., Nair, M. G., Giacomin, P. R., Everett, L. J., Feng, D., Steger, D. J., Schug, J., Artis, D., et al. (2011) · Genes & Development · doi:10.1101/gad.175950.111 · Cited by 314 · see citing works
Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells.
McInnes, A., & Rennick, D. M. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.2.598 · Cited by 310 · see citing works
Contribution of metabolic reprogramming to macrophage plasticity and function
Kasmi, K. C. E., & Stenmark, K. R. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.09.001 · Cited by 276 · see citing works
Osteoimmunomodulatory properties of magnesium scaffolds coated with β-tricalcium phosphate
Chen, Z., Mao, X., Tan, L., Friis, T., Wu, C., Crawford, R., & Xiao, Y. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.038 · Cited by 267 · see citing works
Macrophages specifically regulate the concentration of their own growth factor in the circulation.
Bartocci, A., Mastrogiannis, D. S., Migliorati, G., Stockert, R. J., Wolkoff, A. W., & Stanley, E. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.17.6179 · Cited by 267 · see citing works
Rey-Giraud, F., Hafner, M., & Ries, C. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042656 · Cited by 256 · see citing works
Kawakami, N., Nägerl, U. V., Odoardi, F., Bonhoeffer, T., Wekerle, H., & Flügel, A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050011 · Cited by 248 · see citing works
MicroRNAs in Immune Response and Macrophage Polarization
Liu, G., & Abraham, E. H. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300068 · Cited by 243 · see citing works
Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression
DeFife, K. M., Jenney, C. R., McNally, A. K., Colton, E., & Anderson, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3385 · Cited by 228 · see citing works
Biocompatibility of implants: lymphocyte/macrophage interactions
Anderson, J. M., & McNally, A. K. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0244-1 · Cited by 226 · see citing works
Giant cell formation and function
Brodbeck, W. G., & Anderson, J. M. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32831ac52e · Cited by 222 · see citing works
Wang, Q., Ni, H., Lan, L., Wei, X., Xiang, R., & Wang, Y. (2010) · Cell Research · doi:10.1038/cr.2010.52 · Cited by 219 · see citing works
Macrophage Arginine Metabolism to Ornithine/Urea or Nitric Oxide/Citrulline: A Life or Death Issue
Mills, C. D. (2001) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v21.i5.10 · Cited by 212 · see citing works
Du, F., Yu, F., Wang, Y., Hui, Y. Y., Carnevale, K. A., Fu, M., Lu, H. S., & Fan, D. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302701 · Cited by 209 · see citing works
Monocyte subsets in man and other species
Ziegler‐Heitbrock, L. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.03.019 · Cited by 200 · see citing works
The Monocyte to Macrophage Transition in the Murine Sterile Wound
Crane, M., Daley, J. M., Vanhoutte, O., Brancato, S. K., Henry, W., & Albina, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086660 · Cited by 195 · see citing works
Macrophage Fusion and Multinucleated Giant Cells of Inflammation
McNally, A. K., & Anderson, J. M. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0763-4_7 · Cited by 189 · see citing works
SOCS Proteins in Macrophage Polarization and Function
Wilson, H. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00357 · Cited by 188 · see citing works
Rethinking Regenerative Medicine: A Macrophage-Centered Approach
Brown, B., Sicari, B. M., & Badylak, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00510 · Cited by 185 · see citing works
Strain-dependent modulation of macrophage polarization within scaffolds
Ballotta, V., Driessen-Mol, A., Bouten, C. V. C., & Baaijens, F. P. T. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.002 · Cited by 182 · see citing works
Homeostasis in the mononuclear phagocyte system
Jenkins, S. J., & Hume, D. A. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.06.006 · Cited by 178 · see citing works
Regulation of macrophage functions by L-arginine.
Albina, J. E., Caldwell, M. D., Henry, W. L., & Mills, C. D. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.3.1021 · Cited by 173 · see citing works
Lehtonen, A., Ahlfors, H., Veckman, V., Miettinen, M., Lahesmaa, R., & Julkunen, I. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307194 · Cited by 163 · see citing works
Vasconcelos, D. P., Costa, M. M., Amaral, I. F., Barbosa, M. A., Águas, A. P., & Barbosa, J. N. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.035 · Cited by 153 · see citing works
Macrophage polarization following chitosan implantation
Vasconcelos, D. P., Fonseca, A. C., Costa, M. M., Amaral, I. F., Barbosa, M. A., Águas, A. P., & Barbosa, J. N. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.012 · Cited by 152 · see citing works
Iron levels in polarized macrophages: regulation of immunity and autoimmunity
Recalcati, S., Locati, M., Gammella, E., Invernizzi, P., & Cairo, G. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.03.003 · Cited by 150 · see citing works
Wu, C., Chen, Z., Yi, D., Chang, J., & Xiao, Y. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am4060035 · Cited by 144 · see citing works
The response of macrophages to titanium particles is determined by macrophage polarization
Pajarinen, J., Kouri, V., Jämsen, E., Li, T.-F., Mandelin, J., & Konttinen, Y. T. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.06.027 · Cited by 139 · see citing works
Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1β System by IL-13
Scotton, C. J., Martínez, F. O., Smelt, M. J., Sironi, M., Locati, M., Mantovani, A., & Sozzani, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.834 · Cited by 138 · see citing works
Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres
Bartneck, M., Heffels, K., Pan, Y., Bovi, M., Zwadlo‐Klarwasser, G., & Gröll, J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.050 · Cited by 133 · see citing works
The Effect of Biomaterials Used for Tissue Regeneration Purposes on Polarization of Macrophages
Boersema, G. S. A., Grotenhuis, N., Bayon, Y., Lange, J. F., & Bastiaansen-Jenniskens, Y. M. (2016) · BioResearch open access · doi:10.1089/biores.2015.0041 · Cited by 110 · see citing works
In vitro response of macrophage polarization to a keratin biomaterial
Fearing, B. V., & Dyke, M. E. V. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.04.003 · Cited by 109 · see citing works
van de Garde, M. D. B., Martínez, F. O., Melgert, B. N., Hylkema, M. N., Jonkers, R. E., & Hamann, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302138 · Cited by 108 · see citing works
Role of macrophages in normal wound healing: an overview
Adamson, R. (2009) · Journal of Wound Care · doi:10.12968/jowc.2009.18.8.43636 · Cited by 104 · see citing works
Kajahn, J., Franz, S., Rueckert, E., Forstreuter, I., Hintze, V., Moeller, S. J., & Simon, J. C. (2012) · Biomatter · doi:10.4161/biom.22855 · Cited by 101 · see citing works
Extrinsic and intrinsic control of macrophage inflammatory responses
Cohen, H. B., & Mosser, D. M. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0413236 · Cited by 101 · see citing works
Beljaars, L., Schippers, M., Reker‐Smit, C., Martínez, F. O., Helming, L., Poelstra, K., & Melgert, B. N. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00430 · Cited by 97 · see citing works
Franz, S., Allenstein, F., Kajahn, J., Forstreuter, I., Hintze, V., Möller, S., & Simon, J. C. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.11.016 · Cited by 96 · see citing works
Induction of specific macrophage subtypes by defined micro-patterned structures
Bartneck, M., Schulte, V. A., Paul, N. E., Diez, M., Lensen, M. C., & Zwadlo-Klarwasser, G. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.04.025 · Cited by 87 · see citing works
Macrophage phenotypes in the collagen-induced foreign body reaction in rats
van Putten, S. M., Ploeger, D. T. A., Popa, E. R., & Bank, R. A. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.01.022 · Cited by 82 · see citing works
The Elusive Antifibrotic Macrophage
Adhyatmika, A., Putri, K. S. S., Beljaars, L., & Melgert, B. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00081 · Cited by 74 · see citing works
A culture model to analyze the acute biomaterial-dependent reaction of human primary macrophages
Grotenhuis, N., Bayon, Y., Lange, J. F., van Osch, G. J. V. M., & Bastiaansen-Jenniskens, Y. M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.02.054 · Cited by 71 · see citing works
The second touch hypothesis: T cell activation, homing and polarization
Ley, K. F. (2014) · F1000Research · doi:10.12688/f1000research.3-37.v2 · Cited by 71 · see citing works
McNally, A. K., & Anderson, J. M. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63474-8 · Cited by 69 · see citing works
Microsphere size influences the foreign body reaction
Zandstra, J., Hiemstra, C., Petersen, A., Zuidema, J., van Beuge, M., Rodríguez, S., Lathuile, A., Veldhuis, G. J., Steendam, R., Bank, R. A., et al. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a23 · Cited by 66 · see citing works
Response of human macrophages to wound matrices in vitro
Witherel, C. E., Graney, P. L., Freytes, D. O., Weingarten, M. S., & Spiller, K. L. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12423 · Cited by 65 · see citing works
Regulation of macrophage phenotype by long-term exposure to IL-10
Park‐Min, K., Antoniv, T. T., & Ivashkiv, L. B. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.002 · Cited by 58 · see citing works
Exploiting the inflammatory response on biomaterials research and development
Anderson, J. M. (2015) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-015-5423-5 · Cited by 52 · see citing works
Predicting In Vivo Responses to Biomaterials via Combined In Vitro and In Silico Analysis
Wolf, M. T., Yoram Vodovotz, B., Tottey, S., Brown, B. N., & Badylak, S. F. (2014) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2014.0167 · Cited by 51 · see citing works
Akilbekova, D., Philiph, R., Graham, A., & Bratlie, K. M. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35169 · Cited by 47 · see citing works
Human monocytes and macrophages differ in their mechanisms of adaptation to hypoxia
Fangradt, M., Hahne, M., Gaber, T., Strehl, C., Rauch, R., Hoff, P., Löhning, M., Burmester, G. R., & Buttgereit, F. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4011 · Cited by 45 · see citing works
Grotenhuis, N., van der Toom, H., Kops, N., Bayon, Y., Deerenberg, E. B., Mulder, I. M., van Osch, G. J. V. M., Lange, J. F., & Bastiaansen-Jenniskens, Y. M. (2014) · British journal of surgery · doi:10.1002/bjs.9523 · Cited by 43 · see citing works
Palmer, J. A., Abberton, K. M., Mitchell, G. M., & Morrison, W. A. (2014) · Cells Tissues Organs · doi:10.1159/000363693 · Cited by 42 · see citing works
Kinetics of IL-10-induced gene expression in human macrophages
Antoniv, T. T., Park‐Min, K., & Ivashkiv, L. B. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.003 · Cited by 31 · see citing works
Bullers, S. J., Baker, S. C., Ingham, E., & Southgate, J. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0628 · Cited by 31 · see citing works
Lucke, S., Hoene, A., Walschus, U., Kob, A., Pissarek, J.-W., & Schlosser, M. (2015) · BioMed Research International · doi:10.1155/2015/938059 · Cited by 29 · see citing works
Characteristics of “Tip-DCs and MDSCs” and Their Potential Role in Leishmaniasis
Schmid, M., Wege, A. K., & Ritter, U. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00074 · Cited by 24 · see citing works
Wolf, M. F., Lossdörfer, S., Küpper, K., & Jäger, A. (2013) · European Journal of Orthodontics · doi:10.1093/ejo/cjt037 · Cited by 23 · see citing works
Chin, L., Calabro, A. R., Rodríguez, E. R., Tan, C. D., Walker, E., & Derwin, K. A. (2011) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-011-4325-4 · Cited by 21 · see citing works
Ehashi, T., Takemura, T., Hanagata, N., Minowa, T., Kobayashi, H., Ishihara, K., & Yamaoka, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085132 · Cited by 20 · see citing works
Macrophage behavior on multilayered DNA‐coatings in vitro
van den Beucken, J. J. J. P., Walboomers, X. F., Vos, M. R. J., Sommerdijk, N. A. J. M., Nolte, R. J. M., & Jansen, J. A. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30971 · Cited by 16 · see citing works
Ehashi, T., Kakinoki, S., & Yamaoka, T. (2014) · Journal of Artificial Organs · doi:10.1007/s10047-014-0791-z · Cited by 10 · see citing works
Flagged first, then by citations
2 of the 136 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
Carnicer-Lombarte, A., Chen, S.-T., Malliaras, G. G., & Barone, D. G. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.622524 · Cited by 454 · see citing works
“M2 macrophages decrease inflammatory activity by releasing anti-inflammatory cytokines such as IL-10 (Klopfleisch, 2016).”
BackgroundMartin, K. E., & Garcı́a, A. J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.038 · Cited by 375 · see citing works
Zou, J., Yang, W., Cui, W., Li, C., Ma, C., Ji, X., Hong, J., Qu, Z., Chen, J., Liu, A., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01778-6 · Cited by 318 · see citing works
Kasravi, M., Ahmadi, A., Babajani, A., Mazloomnejad, R., Hatamnejad, M. R., Shariatzadeh, S., Bahrami, S., & Niknejad, H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00348-z · Cited by 316 · see citing works
“Within a few days, attracted macrophages, mostly from inflammatory phenotype (M1 macrophages), form foreign body giant cells, which release potent enzymes and accelerate graft degradation [23].”
BackgroundHernandez, J. L., & Woodrow, K. A. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102087 · Cited by 270 · see citing works
Space-Selective Chemodynamic Therapy of CuFe5O8 Nanocubes for Implant-Related Infections
Guo, G., Zhang, H., Shen, H., Zhu, C., He, R., Tang, J. L., Wang, Y., Jiang, X., Wang, J., Bu, W., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c05255 · Cited by 210 · see citing works
Bone Repair Biomaterials: A Perspective from Immunomodulation
Wang, Y., Zhang, H., Hu, Y., Jing, Y., Geng, Z., & Su, J. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202208639 · Cited by 209 · see citing works
Xin, L., Lin, X.-N., Zhou, F., Li, C., Wang, X., Yu, H.-Y., Pan, Y., Fei, H., Ma, L., & Zhang, S.-Y. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.06.029 · Cited by 173 · see citing works
Huang, Q., Ouyang, Z., Tan, Y., Wu, H. P., & Liu, Y. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.09.030 · Cited by 188 · see citing works
Extracellular Vesicles in Fatty Liver Promote a Metastatic Tumor Microenvironment
Wang, Z.-J., Kim, S. Y., Tu, W., Kim, J., Xu, A. M., Yang, Y. M., Matsuda, M., Reolizo, L., Tsuchiya, T., Billet, S., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.013 · Cited by 181 · see citing works
Mao, Z., Bi, X., Yu, C., Chen, L., Shen, J., Huang, Y., Wu, Z., Qi, H. M., Guan, J., Shu, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48417-8 · Cited by 170 · see citing works
Ruiz, S., Tamayo, J. A., Delgado‐Ospina, J., Porras, D. P. N., Zapata, M. E. V., Hernández, J. H. M., Valencia-Llano, C. H., Zuluaga, F., & Grande‐Tovar, C. D. (2019) · Biomolecules · doi:10.3390/biom9030109 · Cited by 146 · see citing works
Yang, C., Zhao, C., Wang, X., Shi, M., Zhu, Y., Jing, L., Wu, C., & Chang, J. (2019) · Nanoscale · doi:10.1039/c9nr05730g · Cited by 145 · see citing works
Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration
Gao, A., Liao, Q., Xie, L., Wang, G., Zhang, W., Wu, Y., Li, P., Guan, M., Pan, H., Tong, L., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119642 · Cited by 144 · see citing works
The inflammasome in host response to biomaterials: Bridging inflammation and tissue regeneration
Vasconcelos, D. P., Águas, A. P., Barbosa, M. A., Pelegrı́n, P., & Barbosa, J. N. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.056 · Cited by 134 · see citing works
Advances in the repair of segmental nerve injuries and trends in reconstruction
Pan, D., Mackinnon, S. E., & Wood, M. D. (2019) · Muscle & Nerve · doi:10.1002/mus.26797 · Cited by 133 · see citing works
Brooks, P. J., Glogauer, M., & McCulloch, C. A. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.02.006 · Cited by 129 · see citing works
Schoenenberger, A. D., Tempfer, H., Lehner, C., Egloff, J., Mauracher, M., Bird, A., Widmer, J., Maniura-Weber, K., Fucentese, S. F., Traweger, A., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120034 · Cited by 130 · see citing works
Macrophage-targeted nanomedicine for chronic diseases immunotherapy
Song, Y., Huang, Y., Zhou, F., Ding, J., & Zhou, W. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.08.090 · Cited by 126 · see citing works
Liu, C., Zhang, X., Tan, Q., Xu, W.-X., Zhou, C., Luo, M., Li, X., Huang, R.-Y., & Zeng, X. Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188317 · Cited by 110 · see citing works
Li, L., Li, Q., Gui, L., Deng, Y., Wang, L., Jiao, J., Hu, Y., Lan, X., Hou, J., Li, Y., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.037 · Cited by 103 · see citing works
Liu, X., Chen, W.-L., Shao, B., Zhang, X., Wang, Y., Zhang, S., & Wu, W. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120998 · Cited by 101 · see citing works
Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy
Zhao, X., Li, Q., Guo, Z., & Li, Z. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02650-w · Cited by 99 · see citing works
Huang, Q., Li, X., Elkhooly, T. A., Liu, X., Zhang, R., Wu, H. P., Feng, Q., & Liu, Y. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.06.020 · Cited by 94 · see citing works
Meng, X., Duan, C., Pang, H., Chen, Q., Han, B. R., Zha, C., Dinislam, M., Wu, P., Li, Z., Zhao, S., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.067 · Cited by 91 · see citing works
Chen, J., Li, M., Yang, C., Yin, X., Duan, K., Wang, J., & Feng, B. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.01.007 · Cited by 86 · see citing works
Capella-Monsonís, H., Crum, R. J., Hussey, G. S., & Badylak, S. F. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115347 · Cited by 84 · see citing works
Modulating the foreign body response of implants for diabetes treatment
Kharbikar, B. N., Chendke, G. S., & Desai, T. A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.011 · Cited by 83 · see citing works
Poly-D,L-Lactic Acid Stimulates Angiogenesis and Collagen Synthesis in Aged Animal Skin
Oh, S., Seo, S. B., Kim, G., Batsukh, S., Son, K. H., & Byun, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097986 · Cited by 85 · see citing works
Rojo, J. M., Diez‐Orejas, R., Cicuéndez, M., Casarrubios, L., Rojo, J. M., & Portolés, M. T. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.12.063 · Cited by 78 · see citing works
Polypropylene mesh implantation for hernia repair causes myeloid cell–driven persistent inflammation
Heymann, F., von Trotha, K.-T., Preisinger, C., Lynen-Jansen, P., Roeth, A. A., Geiger, M., Geisler, L. J., Frank, A. K., Conze, J., Luedde, T., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123862 · Cited by 79 · see citing works
Effect of tissue microenvironment on fibrous capsule formation to biomaterial-coated implants
Hernandez, J. L., Park, J., Yao, S., Blakney, A. K., Nguyen, H. V., Katz, B. H., Jensen, J. T., & Woodrow, K. A. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120806 · Cited by 78 · see citing works
Time-course assessment of the aggregation and metabolization of magnetic nanoparticles
Rojas, J. M., Gavilán, H., del Dedo, V., Lorente-Sorolla, E., Sanz-Ortega, L., da Silva, G. B., Costo, R., Pérez-Yagüe, S., Talelli, M., Marciello, M., et al. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.05.047 · Cited by 76 · see citing works
Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization
Shayan, M., Padmanabhan, J., Morris, A. H., Cheung, B. H., Smith, R., Schroers, J., & Kyriakides, T. R. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.05.051 · Cited by 75 · see citing works
Antimicrobial Biomaterials for Chronic Wound Care
Miron, A., Giurcăneanu, C., Mihai, M. M., Beiu, C., Voiculescu, V. M., Popescu, M. N., Soare, E., & Popa, L. G. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061606 · Cited by 75 · see citing works
Nanoscale Drug Delivery Systems in Glioblastoma
Liu, Z., Ji, X., Dong, H., Zhang, R., Liu, Q., & Xin, T. (2022) · Nanoscale Research Letters · doi:10.1186/s11671-022-03668-6 · Cited by 70 · see citing works
Sun, A. R., Udduttula, A., Li, J., Liu, Y., Ren, P., & Zhang, P. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.07.004 · Cited by 70 · see citing works
Tan, J., Zhang, Q., Song, Y., Huang, K., Jiang, Y., Chen, J., Wang, R., Zou, C., Li, Q., Qin, B., et al. (2022) · Composites Part B Engineering · doi:10.1016/j.compositesb.2022.110149 · Cited by 68 · see citing works
Shi, X., Xu, C., Chen, Z., Li, M., Yin, Z., Wang, B., Li, Y., Wu, Y., Wu, X., & Xu, Y. (2025) · Bone Research · doi:10.1038/s41413-025-00471-8 · Cited by 75 · see citing works
The Influence of Polysaccharides‐Based Material on Macrophage Phenotypes
Li, Z., & Bratlie, K. M. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100031 · Cited by 66 · see citing works
The markers to delineate different phenotypes of macrophages related to metabolic disorders
Wei, Q., Deng, Y., Yang, Q., Zhan, A., & Wang, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1084636 · Cited by 63 · see citing works
Progress in the Field of Micro-Electrocorticography
Shokoueinejad, M., Park, D., Jung, Y. H., Brodnick, S. K., Novello, J., Dingle, A. M., Swanson, K. I., Baek, D.-H., Suminski, A. J., Lake, W. B., et al. (2019) · Micromachines · doi:10.3390/mi10010062 · Cited by 61 · see citing works
Kanaya, N., Chang, G., Wu, X., Saeki, K., Bernal, L., Shim, H.-J., Wang, J., Warden, C., Yamamoto, T., Li, J., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0618-9 · Cited by 62 · see citing works
Du, J., Chu, Y., Hu, Y., Liu, J., Liu, H., Wang, H., Yang, C., Wang, Z., Yu, A., & Ran, J. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.10.014 · Cited by 60 · see citing works
Barbeck, M., Kühnel, L., Witte, F., Pissarek, J., Precht, C., Xiong, X. B., Krastev, R., Wegner, N., Walther, F., & Jung, O. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093098 · Cited by 58 · see citing works
Mulens‐Arias, V., Rojas, J. M., Sanz-Ortega, L., Portilla, Y., Pérez-Yagüe, S., & Barber, D. F. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102063 · Cited by 58 · see citing works
Gao, H., Wang, L., Jin, H., Lin, Z., Li, Z., Kang, Y., Lyu, Y., Dong, W., Liu, Y., Shi, D., et al. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13040243 · Cited by 57 · see citing works
Das, M., Nariya, P., Joshi, A., Vohra, A., Devkar, R. V., Seshadri, S., & Thakore, S. I. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116751 · Cited by 57 · see citing works
Qi, D., Su, J. D., Li, S., Zhu, H., Cheng, L., Hua, S., Yuan, X., Jiang, J., Shu, Z., Shi, Y., et al. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212759 · Cited by 55 · see citing works
Wang, Z., Chu, Y., Du, J., Hu, Y., Wang, H., Liu, H., Yang, C., Wang, M., Ran, J., & Yu, A. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.123082 · Cited by 54 · see citing works
Activation of Macrophages in Response to Biomaterials
Rayahin, J., & Gemeinhart, R. A. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_13 · Cited by 55 · see citing works
The host response in tissue engineering: Crosstalk between immune cells and cell-laden scaffolds
Saleh, L. S., & Bryant, S. J. (2018) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2018.03.006 · Cited by 54 · see citing works
Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells
Dey, A. K., Gonon, A., Pécheur, E., Pezet, M., VILLIERS, C. L., & Marche, P. N. (2021) · Cells · doi:10.3390/cells10010096 · Cited by 56 · see citing works
Liang, L., Song, D., Wu, K., Ouyang, Z., Huang, Q., Lei, G., Zhou, K., Xiao, J. R., & Wu, H. P. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00262-w · Cited by 52 · see citing works
Polyphenolic-modified cellulose acetate membrane for bone regeneration through immunomodulation
Zhang, Q., Tan, J., Huang, K., Nie, R., Feng, Z.-Y., Zou, C., Li, Q., Chen, J., Sheng, N., Qin, B., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120546 · Cited by 52 · see citing works
Mao, L., Zhou, H., Chen, L., Niu, J., Zhang, L., Yuan, G., & Song, C. (2017) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2017.05.280 · Cited by 52 · see citing works
Heterogeneity and Actin Cytoskeleton in Osteoclast and Macrophage Multinucleation
Takito, J., & Nakamura, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186629 · Cited by 50 · see citing works
de Bakker, E., van den Broek, L. J., Ritt, M. J. P. F., Gibbs, S., & Niessen, F. B. (2018) · Aesthetic Plastic Surgery · doi:10.1007/s00266-018-1211-1 · Cited by 48 · see citing works
Dutta, S. D., Patil, T. V., Ganguly, K., Randhawa, A., & Lim, K. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.05.014 · Cited by 52 · see citing works
In vitro and in vivo models for assessing the host response to biomaterials
Saleh, L., & Bryant, S. J. (2017) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2018.04.002 · Cited by 44 · see citing works
Darzi, S., Deane, J. A., Nold‐Petry, C. A., Edwards, S. E., Gough, D. J., Mukherjee, S., Gurung, S., Tan, K., Vashi, A. V., Werkmeister, J. A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24919-6 · Cited by 45 · see citing works
Dharmadhikari, S., Liu, L., Shontz, K. M., Wiet, M. G., White, A., Goins, A., Akula, H., Johnson, J. K., Reynolds, S. D., Breuer, C. K., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.11.008 · Cited by 45 · see citing works
Immune response of macrophages on super-hydrophilic TiO 2 nanotube arrays
Gao, S., Lu, R., Wang, X., Chou, J., Wang, N., Huai, X., Wang, C., Zhao, Y., & Chen, S. (2020) · Journal of Biomaterials Applications · doi:10.1177/0885328220903249 · Cited by 45 · see citing works
Emerging applications of nanotechnology in context to immunology: A comprehensive review
Mobeen, H., Safdar, M., Fatima, A., Afzal, S., Zaman, H., & Mehdi, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1024871 · Cited by 44 · see citing works
The immunomodulatory role of sulfated chitosan in BMP-2-mediated bone regeneration
Shu, Y., Yu, Y., Zhang, S., Wang, J., Xiao, Y., & Liu, C. (2018) · Biomaterials Science · doi:10.1039/c8bm00701b · Cited by 44 · see citing works
Hu, Y., Tang, L., Wang, Z., Yan, H., Yi, X., Wang, H., Ma, L., Yang, C., Ran, J., & Yu, A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.11.015 · Cited by 43 · see citing works
Zhang, X., Yu, W., Zhang, Y., Zhang, W., Wang, J., Gu, M., Cheng, S., Ren, G., Zhao, B., & Yuan, W. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.05.222 · Cited by 43 · see citing works
Zhou, W., Liu, Y., Nie, X., Zhu, C., Xiong, L., Zhou, J., & Huang, W. H. (2025) · Nature Communications · doi:10.1038/s41467-025-58444-8 · Cited by 43 · see citing works
Grande‐Tovar, C. D., Castro, J. I., Valencia-Llano, C. H., Porras, D. P. N., Hernández, J. H. M., Zapata, M. E. V., Velásquez, J. D. J. D., & Chaur, M. N. (2019) · Biomolecules · doi:10.3390/biom9110684 · Cited by 43 · see citing works
Wang, Y., Jia, Q., Zhang, Y., Wei, J., & Liu, P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.590929 · Cited by 43 · see citing works
Deficiency of Calcitonin Gene-Related Peptide Affects Macrophage Polarization in Osseointegration
Yuan, Y., Jiang, Y., Wang, B., Guo, Y., Gong, P., & Xiang, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00733 · Cited by 42 · see citing works
Gao, L., Li, M., Yin, L., Zhao, C., Chen, J., Zhou, J., Duan, K., & Feng, B. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36391 · Cited by 42 · see citing works
Gurevich, D., French, K., Collin, J. D., Cross, S., & Martin, P. B. (2019) · Journal of Cell Science · doi:10.1242/jcs.236075 · Cited by 42 · see citing works
3D Printed Polyurethane Scaffolds for the Repair of Bone Defects
Cooke, M. E., Ramírez-GarcíaLuna, J. L., Rangel-Berridi, K., Park, H., Nazhat, S. N., Weber, M. H., Henderson, J. E., & Rosenzweig, D. H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.557215 · Cited by 42 · see citing works
Yu, J., Lin, Y., Wang, G., Song, J.-L., Hayat, U., Liu, C., Raza, A., Huang, X., Lin, H., & Wang, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.11.035 · Cited by 42 · see citing works
Biomaterials-Driven Sterile Inflammation
Chen, H., Agrawal, D. K., & Thankam, F. G. (2022) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2020.0253 · Cited by 41 · see citing works
Li, H., Sun, J., Yang, H., Han, X., Luo, X., Liao, L., Yang, B., Zhu, T., Huo, F., Guo, W., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.029 · Cited by 40 · see citing works
Formation and biological activities of foreign body giant cells in response to biomaterials
Cai, F., Jiang, B., & He, F. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.08.034 · Cited by 43 · see citing works
Mori, H., & Hara, M. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.05.021 · Cited by 40 · see citing works
Huang, Q., Li, X., Elkhooly, T. A., Xu, S., Liu, X., Feng, Q., Wu, H. P., & Liu, Y. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.05.010 · Cited by 40 · see citing works
Zhang, Q.-Y., Tan, J., Nie, R., Song, Y.-T., Zhou, X., Feng, Z.-Y., Huang, K., Zou, C.-Y., Yuan, Q.-J., Zhao, L.-M., et al. (2023) · Composites Part B: Engineering · doi:10.1016/j.compositesb.2023.110550 · Cited by 35 · see citing works
Liu, L., Chen, H., Zhao, X., Han, Q., Xu, Y., Liu, Y., Zhang, A., Li, Y., Zhang, W., Chen, B., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101410 · Cited by 42 · see citing works
Pathology of Bioabsorbable Implants in Preclinical Studies
Rousselle, S. D., Ramot, Y., Nyska, A., & Jackson, N. D. (2019) · Toxicologic Pathology · doi:10.1177/0192623318816681 · Cited by 39 · see citing works
Evaluation of Marine Agarose Biomaterials for Tissue Engineering Applications
Irastorza, A., Sánchez‐Porras, D., Ortiz‐Arrabal, O., de Frutos, M. J., Esteban, E., Fernández, J., Janer, A., Campos, A., Campos, F., & Alaminos, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041923 · Cited by 38 · see citing works
Tamayo, M. Z., Gregnanin, G., Cencetti, C., Meo, C. D., Gueguen, V., Letourneur, D., Meddahi‐Pellé, A., Pavon‐Djavid, G., & Matricardi, P. (2017) · Biomedical Materials · doi:10.1088/1748-605x/aa8a86 · Cited by 37 · see citing works
Macrophage Polarization in Response to Biomaterials for Vascularization
Wang, Y., Fan, Y., & Liu, H. (2021) · Annals of Biomedical Engineering · doi:10.1007/s10439-021-02832-w · Cited by 37 · see citing works
Bian, N., Chu, C., Rung, S., Huangphattarakul, V., Man, Y., Lin, J., & Hu, C. (2022) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-022-00491-z · Cited by 38 · see citing works
Li, W., Xu, F., Dai, F., Deng, T., Ai, Y., Xu, Z., He, C., Ai, F., & Li, S. (2023) · Biomaterials Science · doi:10.1039/d3bm00362k · Cited by 36 · see citing works
Zhang, W., Liu, L., Zhou, H., He, C., Yang, X., Fu, J., Wang, H., Liu, Y., & Zheng, Y. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.112151 · Cited by 36 · see citing works
Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction
Chen, Y., Luo, Z., Meng, W., Liu, K., Chen, Q., Cai, Y., Ding, Z., Huang, C., Zhou, Z., Jiang, M., et al. (2024) · Small · doi:10.1002/smll.202310325 · Cited by 38 · see citing works
van Dijk, L. A., Barbieri, D., Groot, F. B., Yuan, H., Oliver, R. A., Christou, C., Walsh, W. R., & de Bruijn, J. D. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34301 · Cited by 35 · see citing works
Li, Y., Guo, X., Dong, S., Zhu, T., Chen, Y., Zhao, S., Xie, G., Jiang, J., He, H., Liu, C., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.07.054 · Cited by 36 · see citing works
Steiner, D., Winkler, S., Heltmann‐Meyer, S., Trossmann, V. T., Fey, T., Scheibel, T., Horch, R. E., & Arkudas, A. (2021) · Biofabrication · doi:10.1088/1758-5090/ac0d9b · Cited by 35 · see citing works
Zhang, D., Lai, L., Fu, H., Fu, Q., & Chen, M. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c21629 · Cited by 35 · see citing works
Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface
Huo, S., & Yue, B. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i7.545 · Cited by 35 · see citing works
Junnan, Q., Huimin, L., Liu, G., & Chen, Y. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.151773 · Cited by 33 · see citing works
Gao, S., Wang, Y., Li, D., Guo, Y., Zhu, M.-F., Xu, S.-X., Mao, J., & Fan, G.-W. (2018) · Inflammation · doi:10.1007/s10753-018-0891-7 · Cited by 33 · see citing works
van Dijk, L. A., Duan, R., Luo, X., Barbieri, D., Pelletier, M. H., Christou, C., Rosenberg, A. J. W. P., Yuan, H., Groot, F. B., Walsh, W. R., et al. (2018) · JOR Spine · doi:10.1002/jsp2.1039 · Cited by 33 · see citing works
Amorphous Calcium Phosphate NPs Mediate the Macrophage Response and Modulate BMSC Osteogenesis
Chen, L., Qiao, P., Liu, H., & Shao, L. (2020) · Inflammation · doi:10.1007/s10753-020-01331-9 · Cited by 34 · see citing works
Yang, L., Wang, P., Zhang, Y., Jin, Z., Bi, X., Qian, Z., Hou, S., Li, L., & Fan, Y. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123289 · Cited by 33 · see citing works
- Authors
- Klopfleisch, R.
- Affiliations
- Freie Universität Berlin (DE)
- Corresponding author
- Klopfleisch, R.
- ORCID
- Klopfleisch, R.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 43
- Pages
- 3-13
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2470932651
- Cited by
- 298
- References
- 136
- Citations by year
- 2026: 7 · 2025: 25 · 2024: 36 · 2023: 32 · 2022: 49 · 2021: 43 · 2020: 40 · 2019: 28 · 2018: 25 · 2017: 12 · 2016: 1
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- macrophages, foreign body reaction, biomaterial biocompatibility, macrophage polarization, M1 macrophages, M2 macrophages, foreign body giant cells, biomaterial degradation, biomaterial integration, macrophage markers, macrophage metabolism, biomaterial design, mouse model
- MeSH terms
- Animals, Biocompatible Materials, Disease Models, Animal, Foreign-Body Reaction, Macrophages, Phenotype, Biomarkers, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review