Cannabis Treatments in Obstetrics and Gynecology: A Historical Review
Abstract
SUMMARY Cannabis has an ancient tradition of usage as a medicine in obstetrics and gynecology. This study presents that history in the literature to the present era, compares it to current ethnobotanical, clinical and epidemiological reports, and examines it in light of modern developments in cannabinoid research. The author believes that cannabis extracts may represent an efficacious and safe alternative for treatment of a wide range of conditions in women including dysmenorrhea, dysuria, hyperemesis gravidarum, and menopausal symptoms.
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Findings from the rat model and clinical studies strongly support the conclusion that this innervation contributes to endometriosis-associated pain.
“Findings from the rat model and clinical studies strongly support the conclusion that this innervation contributes to endometriosis-associated pain [21,45,48].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [45]
Cannabinoids were long used by women to alleviate dysmenorrhea.
“The endocannabinoid system plays a key role in pain mechanisms [42], and, previously, cannabinoids were long used by women to alleviate dysmenorrhea [45].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [45]
Studies were done when the rat was in proestrus, the estrous stage when hyperalgesia in the ENDO model is most severe.
“Studies were done when the rat was in proestrus, the estrous stage when hyperalgesia in the ENDO model is most severe [10,45,38].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [45]
All assessments were done >6 wks after surgery, when ENDO-induced hyperalgesia is fully-developed and stable.
“All assessments were done > 6 wks after the surgery; i.e., when ENDO-induced hyperalgesia is fully-developed and stable [10,45,38].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [45]
Exogenous cannabinoids were once used to alleviate endometriosis-associated pain.
“This situation, together with knowledge that the endocannabinoid system is involved in uterine function and dysfunction and that exogenous cannabinoids were once used to alleviate endometriosis-associated pain, suggests that the endocannabinoid system is involved in both endometriosis and its associated pain.”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [45]
The finding that a cannabinoid agent alleviates hyperalgesia in a rat model of endometriosis is consistent with the known efficacy of cannabinoid agents in women with endometriosis.
“is consistent with the known efficacy of cannabinoid agents in women with endometriosis [45]”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [45]
Approaches targeted at the endocannabinoid system represent a promising new direction for developing new treatments for pain suffered by women with endometriosis.
“the present results suggest that approaches targeted at the endocannbinoid system represent a promising new direction for developing badly-needed new treatments for pain suffered by women with endometriosis.”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [45]
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Self-citationA Systematic Review of Medical Cannabinoids Dosing in Human
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Future of Cannabis and Cannabinoids in Therapeutics
Russo, E. B. (2004) · Journal of Cannabis Therapeutics · doi:10.1300/j175v03n04_04 · Cited by 13 · see citing works
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What Every Pediatric Gynecologist Should Know About Marijuana Use in Adolescents
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The cannabis industry within the USA: the influence of gender on cannabis policy and sales
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Cannabis-Induced Neuroactivity: Research Trends and Commercial Prospects
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Role of Cannabinoids in Various Diseases: A Review
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Exploring the Management of Cannabis Use Among Women and During Pregnancy
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A Perspective on the Phytopharmaceuticals Responsible for the Therapeutic Applications
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Introduction: Cannabis: From Pariah to Prescription
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The Medicinal Use of Cannabis Documented by Muslim Scientists
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Should cannabis be used in the management of endometriosis?
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Future of Cannabis and Cannabinoids
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- Authors
- Russo, E.
- Affiliations
- University of Washington (US)
- Corresponding author
- Russo, Ethan
- ORCID
- Russo, Ethan
- Venue
- Journal of Cannabis Therapeutics
- Publisher
- Informa UK Limited
- Published
- 2002-06
- Volume
- 2
- Issue
- 3-4
- Pages
- 5-35
- ISSN
- 1529-9775 (ISSN-L)
- OpenAlex
- W1886815557
- Cited by
- 71
- References
- 87
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 7 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cannabis Therapeutics (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- cannabis, cannabinoids, obstetrics, gynecology, ethnobotany, dysmenorrhea, dysuria, hyperemesis gravidarum, menopausal symptoms, women's health, cannabis extracts
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