Osteolytic changes accompanying degradation of absorbable fracture fixation implants
Abstract
We analysed the radiographs of 67 patients with displaced malleolar fractures treated by open reduction and internal fixation using absorbable polyglycolide rods. Seventeen patients developed a discharging inflammatory foreign-body reaction, a complication unique to these fixation devices. In 34 patients ovoid osteolytic foci, usually 5 to 10 mm in diameter, appeared within the implant channels six to 12 weeks after the operation. The same lesion occurred in 14 of the 17 patients who developed a foreign-body reaction, whereas only 20 out of the 50 patients with an uneventful course showed osteolytic areas (p less than 0.01). In patients with a foreign-body reaction the osteolytic foci tended to occur in the deepest parts of the implant channels. However, after one year the normal structure of the bone was restored.
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In clinical studies where PGA was used as fracture fixation, foreign-body responses or osteolytic reactions have been reported.
“In clinical studies where PGA was used as fracture fixation, foreign-body responses or osteolytic reactions have been reported”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Böstman, 1991
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- Authors
- Bostman, O.
- Affiliations
- Helsinki University Central Hospital, Finland.
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 1991-07
- Volume
- 73-B
- Issue
- 4
- Pages
- 679-682
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W2153688535
- Cited by
- 294
- References
- 0
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 12 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 6 · 2012: 8
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Bone and Joint Surgery - British Volume (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Foot and Ankle Surgery
- Health Sciences › Medicine › Surgery › Facial Trauma and Fracture Management
- Keywords
- osteolysis, absorbable implants, fracture fixation, foreign body reaction, ankle fractures, implant degradation, bone regeneration
- MeSH terms
- Adult, Biodegradation, Environmental, Fibula, Follow-Up Studies, Foreign-Body Reaction, Fracture Fixation, Internal, Humans, Osteolysis, Polyglycolic Acid, Polymers, Radiography, Tibial Fractures, Ankle Injuries, Prostheses and Implants, Fractures, Bone
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