Recent Developments in Ring Opening Polymerization of Lactones for Biomedical Applications
Abstract
Aliphatic polyesters prepared by ring-opening polymerization of lactones are now used worldwide as bioresorbable devices in surgery (orthopaedic devices, sutures, stents, tissue engineering, and adhesion barriers) and in pharmacology (control drug delivery). This review presents the various methods of the synthesis of polyesters and tailoring the properties by proper control of molecular weight, composition, and architecture so as to meet the stringent requirements of devices in the medical field. The effect of structure on properties and degradation has been discussed. The applications of these polymers in the biomedical field are described in detail.
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ROP has been the method of choice for the synthesis of tailor-made drug delivery systems where complex architectures and precise molecular weights are essential to their performance.
“For this reason, ROP has been the method of choice for the synthesis of tailor-made drug delivery systems where complex architectures and precise molecular weights are essential to their performance.269,270”
From Catalysis as an Enabling Science for Sustainable Polymers (2018) · cites this paper as [269]
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“Their synthesis can be achieved by the ring-opening polymerization (ROP) of the cyclic esters lactide (LA) and ε-caprolactone (CL), respectively [4,5].”
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- Authors
- Albertsson, A.-C., & Varma, I. K.
- Affiliations
- Indian Institute of Technology Delhi (IN)
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-10-23
- Volume
- 4
- Issue
- 6
- Pages
- 1466-1486
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2034387102
- Cited by
- 1,582
- References
- 311
- Citations by year
- 2026: 31 · 2025: 34 · 2024: 43 · 2023: 52 · 2022: 48 · 2021: 71 · 2020: 73 · 2019: 75 · 2018: 79 · 2017: 81 · 2016: 99 · 2015: 89 · 2014: 111 · 2013: 95 · 2012: 111
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- ring-opening polymerization, lactones, aliphatic polyesters, bioresorbable polymers, biodegradation, structure-property relationships, molecular weight control, polymer architecture, orthopedic devices, sutures, stents, tissue engineering, anti-adhesion barrier, controlled drug delivery
- MeSH terms
- Biocompatible Materials, Biodegradation, Environmental, Catalysis, Lactones, Polyesters, Absorbable Implants
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