Cited by 1,582biodegradable polymer synthesis and propertiesSurgical Sutures and AdhesivesAdvanced Drug Delivery Systems

Recent Developments in Ring Opening Polymerization of Lactones for Biomedical Applications

Albertsson, Ann-Christine, Varma, Indra K.·2003·Biomacromolecules

Abstract

Aliphatic polyesters prepared by ring-opening polymerization of lactones are now used worldwide as bioresorbable devices in surgery (orthopaedic devices, sutures, stents, tissue engineering, and adhesion barriers) and in pharmacology (control drug delivery). This review presents the various methods of the synthesis of polyesters and tailoring the properties by proper control of molecular weight, composition, and architecture so as to meet the stringent requirements of devices in the medical field. The effect of structure on properties and degradation has been discussed. The applications of these polymers in the biomedical field are described in detail.

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Registry

Crossref · 10.1021/bm034247a

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311 of 311 references verified0 citation errors · 0 not checkable

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  • ROP has been the method of choice for the synthesis of tailor-made drug delivery systems where complex architectures and precise molecular weights are essential to their performance.

    “For this reason, ROP has been the method of choice for the synthesis of tailor-made drug delivery systems where complex architectures and precise molecular weights are essential to their performance.269,270”

    From Catalysis as an Enabling Science for Sustainable Polymers (2018) · cites this paper as [269]

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Authors
Albertsson, A.-C., & Varma, I. K.
Affiliations
Indian Institute of Technology Delhi (IN)
Venue
Biomacromolecules
Published
2003-10-23
Volume
4
Issue
6
Pages
1466-1486
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W2034387102
Cited by
1,582
References
311
Citations by year
2026: 31 · 2025: 34 · 2024: 43 · 2023: 52 · 2022: 48 · 2021: 71 · 2020: 73 · 2019: 75 · 2018: 79 · 2017: 81 · 2016: 99 · 2015: 89 · 2014: 111 · 2013: 95 · 2012: 111
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Biomacromolecules (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
ring-opening polymerization, lactones, aliphatic polyesters, bioresorbable polymers, biodegradation, structure-property relationships, molecular weight control, polymer architecture, orthopedic devices, sutures, stents, tissue engineering, anti-adhesion barrier, controlled drug delivery
MeSH terms
Biocompatible Materials, Biodegradation, Environmental, Catalysis, Lactones, Polyesters, Absorbable Implants

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