The level of vitamin D in the serum correlates with fatty degeneration of the muscles of the rotator cuff
Open accessAbstract
This study examined the role of vitamin D as a factor accounting for fatty degeneration and muscle function in the rotator cuff. There were 366 patients with disorders of the shoulder. A total of 228 patients had a full-thickness tear (group 1) and 138 patients had no tear (group 2). All underwent magnetic resonance arthrography and an isokinetic muscle performance test. The serum concentrations of vitamin D (25(OH)D(3)) were measured. In general, a lower serum level of vitamin D was related to higher fatty degeneration in the muscles of the cuff. Spearman's correlation coefficients were 0.173 (p = 0.001), -0.181 (p = 0.001), and -0.117 (p = 0.026) for supraspinatus, infraspinatus and subscapularis, respectively. In group 1, multivariate linear regression analysis revealed that the serum level of vitamin D was an independent variable for fatty degeneration of the supraspinatus and infraspinatus. The serum vitamin D level has a significant negative correlation with the fatty degeneration of the cuff muscle and a positive correlation with isokinetic muscle torque.
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The active form of vitamin D binds to a highly specific nuclear receptor in muscle tissue and leads to protein synthesis and growth of muscle tissue.
“the active form of vitamin D binds to a highly specific nuclear receptor in the muscle tissue [64,68] and leads to protein synthesis and growth of muscle tissue [64].”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [64]
Serum 25(OH)D levels had a significant negative correlation with fatty degeneration of rotator cuff muscles and a positive correlation with isokinetic muscle performance in men and women with rotator cuff disorders.
“Oh et al. [64] found that serum 25(OH)D levels had a significant negative correlation with fatty degeneration of rotator cuff muscles and a positive correlation with isokinetic muscle performance in men and women with rotator cuff disorders.”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [64]
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- Authors
- Oh, J. H., Kim, S. H., Kim, J. H., Shin, Y. H., Yoon, J. P., & Oh, C. H.
- Affiliations
- Seoul National University (KR)
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 2009-12
- Volume
- 91-B
- Issue
- 12
- Pages
- 1587-1593
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W2159010424
- Cited by
- 93
- References
- 45
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 2 · 2014: 4 · 2013: 10 · 2012: 4
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Bone and Joint Surgery - British Volume (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Shoulder Injury and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Keywords
- vitamin D, serum 25-hydroxyvitamin D, rotator cuff, steatosis, rotator cuff tear, supraspinatus, infraspinatus, subscapularis, shoulder disorders, muscle function
- MeSH terms
- Rotator Cuff Injuries, Adipose Tissue, Adult, Aged, Aged, 80 and over, Calcifediol, Female, Humans, Male, Middle Aged, Radiography, Rupture, Spontaneous, Vitamin D, Biomarkers, Range of Motion, Articular, Rotator Cuff, Young Adult
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