The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Value of p63 and Cytokeratin 5/6 as Immunohistochemical Markers for the Differential Diagnosis of Poorly Differentiated and Undifferentiated Carcinomas
Abstract
Microsatellite instability (MSI), characterized by contraction or expansion in microsatellite length or short tandem repeats compared with germline lengths, is found in 85% to 90% of colon cancer arising in hereditary nonpolyposis colorectal cancer families. These cancers commonly have characteristic histologic appearances, including medullary features with intense lymphoid infiltrates. In pancreatic cancer, a rare medullary histologic subtype more often demonstrates MSI than the more common adenocarcinoma subtype. We hypothesized that the medullary histologic pattern might correlate with MSI in additional tumor types and analyzed 8 cases of typical and atypical medullary carcinoma of the breast. Tumor and normal DNA was extracted from paraffinized tissue blocks of tumor and histologically uninvolved axillary lymph nodes, respectively. We analyzed the tumors for instability in 5 primary (BAT25, BAT26, D17S250, D5S346, D2S123) and 3 alternative (BAT40, D18S55, D18S58) microsatellites recommended at the National Cancer Institute--sponsored conference for diagnosis of MSI in colorectal cancer. All 8 tumors were microsatellite stable at the 8 loci, suggesting that MSI is not commonly associated with medullary or atypical medullary breast carcinoma, in contrast with the reported association with medullary tumors of the colon and pancreas.
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Cites
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Cited by
Travis, W. D., Brambilla, E., Noguchi, M., Nicholson, A. G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D. B., Franklin, W., et al. (2013) · Archives of Pathology and Laboratory Medicine · doi:10.5858/arpa.2012-0263-ra · Cited by 414
Ordóñez, N. G. (2003) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200308000-00001 · Cited by 406
Mukhopadhyay, S., & Katzenstein, A.-L. A. (2011) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3182036d05 · Cited by 314
TP63-mediated enhancer reprogramming drives the squamous subtype of pancreatic ductal adenocarcinoma
Somerville, T. D. D., Xu, Y., Miyabayashi, K., Tiriac, H., Cleary, C. R., Maia-Silva, D., Milazzo, J. P., Tuveson, D. A., & Vakoc, C. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.051 · Cited by 225
Metadata
- Authors
- Kaufmann, O., Fietze, E., Mengs, J., & Dietel, M.
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-12
- Volume
- 116
- Issue
- 6
- Pages
- 823-830
- ISSN
- 0002-9173 (ISSN-L)
- 1943-7722
- OpenAlex
- W2096726228
- Cited by
- 324
- References
- 16
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaufmann, O., Fietze, E., Mengs, J., & Dietel, M. (2001). Value of p63 and Cytokeratin 5/6 as Immunohistochemical Markers for the Differential Diagnosis of Poorly Differentiated and Undifferentiated Carcinomas. American Journal of Clinical Pathology. https://doi.org/10.1309/21tw-2ndg-jrk4-pfjx
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