Cited by 407Sexual function and dysfunction studiesTreatment of Major DepressionSchizophrenia research and treatment

The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.

Antidepressant-Induced Sexual Dysfunction

Gregorian, Razmic S, Golden, Katharine A, Bahce, Asena, Goodman, Clifford, Kwong, W Jacqueline, Khan, Zeba M·2002·Annals of Pharmacotherapy

DOI 10.1345/aph.1a195

Open this paper in CoChat — free account

Abstract

OBJECTIVE: To review the evidence regarding antidepressant-induced sexual dysfunction and address implications for treatment strategy and health plan coverage policies for antidepressant medications. DATA SOURCES: Primary articles were identified by a MEDLINE and HealthSTAR search to identify English-language studies published between January 1986 and July 2000. Search terms included sexual dysfunction or sexual function and antidepressants, fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, venlafaxine, nefazodone, bupropion, and mirtazapine. A cross-check of references cited in 10 published reviews yielded additional in-scope articles. STUDY SELECTION AND DATA EXTRACTION: Approximately 200 articles were identified, including 8 randomized controlled trials and numerous open-label studies, case series, and case reports. Of the randomized controlled trials, only 5 were designed to evaluate the incidence of sexual dysfunction associated with antidepressant treatment. Three additional randomized controlled trials included a structured assessment of sexual dysfunction within an efficacy trial. Data extraction excluded case reports, letters, and other limited study designs. A panel survey augmented published reports. DATA SYNTHESIS: Sexual dysfunction is a relatively common adverse effect of many of the antidepressants in common use today. Rates of sexual dysfunction observed in clinical practice may be higher than those reported in the product information for several agents. Selective serotonin-reuptake inhibitors (SSRIs) appear to be the class of antidepressants most likely to cause sexual dysfunction. Published studies suggest that between 30% and 60% of SSRI-treated patients may experience some form of treatment-induced sexual dysfunction. Bupropion and nefazodone appear to be much less likely to cause sexual dysfunction (≤10% of patients). Mirtazapine also appears to be associated with a low rate of sexual adverse effects. Panel results largely reflect the consensus of the literature. CONCLUSIONS: Sexual dysfunction is a common adverse effect of antidepressant treatment. Physicians should monitor their patients for antidepressant-induced sexual adverse effects, as these may affect compliance with therapy and ultimate treatment success. In addition to the consequences for patient health and well-being, managed-care organizations should be concerned with sexually related adverse effects of antidepressants, insofar as additional healthcare resources may be required to treat depressed patients in whom these adverse effects arise.

Integrity signals

Registry

Crossref · 10.1345/aph.1a195

Cites

207 of 207 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption‐II
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,597
A method for estimating the probability of adverse drug reactions
Naranjo, C. A., Busto, U., Sellers, E. M., Sandor, P., Ruiz, I., Roberts, E. A., Janecek, E., Domecq, C., & Greenblatt, D. J. (1981) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1981.154 · Cited by 11,914
A simulation study of the number of events per variable in logistic regression analysis
Peduzzi, P., Concato, J., Kemper, E., Holford, T. R., & Feinstein, A. R. (1996) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00236-3 · Cited by 9,655
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493
Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
(2001) · New England Journal of Medicine · doi:10.1056/nejmoa010746 · Cited by 6,470
Cancer Cell Cycles
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels
(1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391902 · Cited by 5,261
Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels: Results of AFCAPS/TexCAPS
Downs, J. R., Clearfield, M., Weis, S., Whitney, E., Shapiro, D. R., Beere, P. A., Langendorfer, A., Stein, E. A., Kruyer, W., Gotto, Jr., et al. (1998) · JAMA · doi:10.1001/jama.279.20.1615 · Cited by 5,236

Show all 71 references

Research works printed but not linked: 21

Preskorn SH, 1995, J Clin Psychiatry, 56, 12
Patterson WM, 1993, J Clin Psychiatry, 54, 71
Feiger A, 1996, J Clin Psychiatry, 57, 53
Zajecka J, 1991, J Clin Psychiatry, 52, 66
Herman JB, 1990, J Clin Psychiatry, 51, 25
Segraves RT, 1998, J Clin Psychiatry, 59, 48
Segraves RT, 1993, J Clin Psychiatry Monogr, 11, 57
Rothschild AJ, 2000, J Clin Psychiatry, 61, 28
Hirschfeld RM, 1999, J Clin Psychiatry, 60, 32
Reimherr FW, 1990, J Clin Psychiatry, 51, 18
1994, Diagnostic and statistical manual for psychiatric disorders
Harrison WM, 1985, Psychopharmacol Bull, 21, 85
Balon R, 1993, J Clin Psychiatry, 54, 209
Zajecka J, 1997, Psychopharmacol Bull, 33, 755
Jacobsen FM, 1992, J Clin Psychiatry, 53, 119
Walker PW, 1993, J Clin Psychiatry, 54, 459
1999, Delphi Panel investigation of antidepressant related sexual dysfunction and breakthrough symptoms
Balon R, 1993, J Clin Psychiatry, 54, 161
Hollander E, 1992, J Clin Psychiatry, 53, 207
Balogh S, 1992, J Clin Psychiatry, 53, 212
Sussman N, 1994, J Clin Psychiatry, 55, 45

Sorted by citations

Items 201–300 of 407

Frequency of treatment-emergent sexual dysfunction and treatment effectiveness during SSRI or duloxetine therapy: 8-week data from a 6-month observational study
Dueñas, H., Lee, A. C.-L., Brnabic, A. J. M., Chung, K., Lai, C., Badr, M. G., Uy-Ponio, T., Ruiz, J. R., Varrey, P., Hu, J., et al. (2011) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2011.572169 · Cited by 33
Safety and tolerability of atypical antipsychotics in patients with bipolar disorder: prevalence, monitoring and management
Chue, P., & Kovacs, C. S. (2003) · Bipolar Disorders · doi:10.1111/j.1399-2406.2003.00063.x · Cited by 32
Sexual Function in Nondepressed Women Using Escitalopram for Vasomotor Symptoms
Reed, S. D., Guthrie, K. A., Joffe, H., Shifren, J. L., Seguin‐Fowler, R. A., & Freeman, E. W. (2012) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3182475fa4 · Cited by 30
Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis
Lyons, D. J., Ammari, R., Hellysaz, A., & Broberger, C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4061-15.2016 · Cited by 32
Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior
Sarkar, J., Hiegel, C., Ginis, G. E., Hilbun, E., & Uphouse, L. L. (2007) · Brain Research · doi:10.1016/j.brainres.2007.11.033 · Cited by 30
Effects of aqueous extract of Cnestis ferruginea (Vahl ex De Cantolle) root on paroxetine-induced sexual dysfunction in male rats
Yakubu, T. M., & Nurudeen, Q. O. (2012) · Asian Pacific Journal of Reproduction · doi:10.1016/s2305-0500(13)60060-3 · Cited by 29
Role of 5-HT1A receptors in fluoxetine-induced lordosis inhibition
Guptarak, J., Sarkar, J., Hiegel, C., & Uphouse, L. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.003 · Cited by 28
Acute and long-term cardiovascular effects of stimulant, guanfacine, and combination therapy for attention-deficit/hyperactivity disorder
Sayer, G. R., McGough, J. J., Levitt, J., Cowen, J., Sturm, A., Castelo, E., & McCracken, J. T. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0264 · Cited by 28
Erectile Dysfunction: A Review of Historical Treatments With a Focus on the Development of the Inflatable Penile Prosthesis
Gurtner, K. E., Saltzman, A. F., Hebert, K. L., & Laborde, E. L. (2015) · American Journal of Men s Health · doi:10.1177/1557988315596566 · Cited by 27
“ED can also be a side effect of some medications such as antihypertensives, antidepressants, and antipsychotics (Gregorian et al., 2002; Hatzimouratidis et al., 2010).”
Background
Menopause-Related Quality of Life in Chronically Mentally ILL Women
Friedman, S. H., Sajatovic, M., Schuermeyer, I. N., Safavi, R., Hays, R. W., West, J. A., Ignacio, R. V., & Blow, F. C. (2005) · The International Journal of Psychiatry in Medicine · doi:10.2190/br03-8gyd-5l9j-lu17 · Cited by 27
“SSRIs may also induce sexual dysfunction [14].”
A Systematic Review of Interventions for Inappropriate Sexual Behavior of Children and Adolescents with Developmental Disabilities
McLay, L., Carnett, A., Tyler‐Merrick, G., & van der Meer, L. A. J. (2015) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-015-0058-5 · Cited by 26
Factors associated with sexual arousal, sexual sensation seeking and sexual satisfaction among female African American adolescents
Sales, J. M., Smearman, E., Brody, G. H., Milhausen, R. R., Philibert, R. A., & DiClemente, R. J. (2013) · Sexual Health · doi:10.1071/sh13005 · Cited by 27
Anxiety, depression, and psychosis in Parkinson's disease: unmet needs and treatment challenges
Chen, J. J. (2004) · Neurologic Clinics · doi:10.1016/j.ncl.2004.06.008 · Cited by 26
Thermosensitive hydrogel designed for improving the antidepressant activities of genipin via intranasal delivery
Qi, X., Xu, D. W., Tian, M., Zhou, J., Wang, Q., & Cui, Y. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.109816 · Cited by 25
A Retrospective Database Analysis of Neuropathic Pain and Oral Antidiabetic Medication Use and Adherence Among Texas Adults With Type 2 Diabetes Enrolled in Medicaid
Oladapo, A. O., Barner, J. C., Rascati, K. L., & Strassels, S. A. (2012) · Clinical Therapeutics · doi:10.1016/j.clinthera.2012.02.007 · Cited by 24
Factors influencing fluoxetine-induced sexual dysfunction in female rats
Adams, S., Heckard, D., Hassell, J. E., & Uphouse, L. L. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.029 · Cited by 24
Barriers to achieving treatment goals: A focus on sleep disturbance and sexual dysfunction
Morehouse, R. L., MacQUEEN, G. M., & Kennedy, S. H. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.047 · Cited by 25
Newly diagnosed major depressive disorder and the risk of erectile dysfunction: A population-based cohort study in Taiwan
Huang, S., Lin, C., Chan, C.-H., Loh, E., & Lan, T. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.06.012 · Cited by 25
Animal models of major depressive disorder and the implications for drug discovery and development
Demin, K. A., Sysoev, M., Chernysh, M. V., Savva, A. K., Koshiba, M., Wappler-Guzzetta, E. A., Song, C., de Abreu, M. S., Leonard, B. E., Parker, M. O., et al. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1575360 · Cited by 24
Dose Uniformity of Scored and Unscored Tablets: Application of the FDA Tablet Scoring Guidance for Industry
Ciavarella, A. B., Khan, M. A., Gupta, A., & Faustino, P. J. (2016) · PDA Journal of Pharmaceutical Science and Technology · doi:10.5731/pdajpst.2016.006411 · Cited by 23
Sexual Functioning in Patients With Recurrent Major Depressive Disorder Enrolled in the PREVENT Study
Gelenberg, A. J., Dünner, D. L., Rothschild, A. J., Pedersen, R., Dorries, K. M., & Ninan, P. T. (2013) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e318288d298 · Cited by 24
Lights on MsFLASH: a review of contributions
Reed, S. D., LaCroix, A. Z., Anderson, G. L., Ensrud, K. E., Caan, B. J., Carpenter, J. S., Cohen, L. S., Diem, S. J., Freeman, E. W., Joffe, H., et al. (2020) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001461 · Cited by 24
Views of family physicians on heterosexual sexual function in older adults
Levkovich, I., Gewirtz‐Meydan, A., Karkabi, K., & Ayalon, L. (2018) · BMC Family Practice · doi:10.1186/s12875-018-0770-1 · Cited by 27
“There are many biomedical reasons for erectile dysfunction (ED), such as medication [22], diseases and surgeries [23], diabetes [24], and cardiovascular problems [25].”
Background
Fresh onion juice enhanced copulatory behavior in male rats with and without paroxetine-induced sexual dysfunction
Allouh, M. Z., Daradka, H. M., Barbarawi, M. M. A., & Mustafa, A. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213508360 · Cited by 22
Antidepressant-Like Effects of Central BDNF Administration in Mice of Antidepressant Sensitive Catalepsy (ASC) Strain
Tikhonova, M. A., & Kulikov, A. V. (2012) · The Chinese Journal of Physiology · doi:10.4077/cjp.2012.baa041 · Cited by 22
Selective Serotonin Reuptake Inhibitors (SSRIs) in Pregnancy
Fleschler, R. G., & Peskin, M. F. (2008) · MCN The American Journal of Maternal/Child Nursing · doi:10.1097/01.nmc.0000341255.80426.7b · Cited by 22
Sertraline Suppresses Testis and Adrenal Steroid Production and Steroidogenic Gene Expression While Increasing LH in Plasma of Male Rats Resulting in Compensatory Hypogonadism
Munkboel, C. H., Larsen, L. W., Weisser, J. J., Kristensen, D. M., & Styrishave, B. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy059 · Cited by 22
Serotonin and Sexual Behavior
Uphouse, L. L., & Guptarak, J. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70089-8 · Cited by 21
The Use of Selective Serotonin Reuptake Inhibitors in Elderly Patients
Chemali, Z. N., Chahine, L. M., & Fricchione, G. L. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220903129798 · Cited by 21
Erratum
Dobkin, R. D., Menza, M. A., Marín, H., Allen, L. A., Rousso, R., & Leiblum, S. R. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000194623.07611.90 · Cited by 21
Effects of SNS Activation on SSRI-Induced Sexual Side Effects Differ by SSRI
Lorenz, T. K., & Meston, C. M. (2009) · Journal of Sex & Marital Therapy · doi:10.1080/00926230902851322 · Cited by 20
Use of psychopharmacologic agents in the elderly
Desai, A. K. (2003) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(03)00044-2 · Cited by 20
A novel approach for predicting antidepressant-induced sexual dysfunction in rats
Rizzo, S. J. S., Schechter, L. E., & Rosenzweig-Lipson, S. J. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0924-7 · Cited by 20
Statin-induced focal myositis of the upper extremity. A report of two cases
Wagner, M., Mühldorfer-Fodor, M., Prommersberger, K. J., & Schmitt, R. (2011) · European Journal of Radiology · doi:10.1016/j.ejrad.2010.12.031 · Cited by 19
Adjuvant administration of probiotic effects on sexual function in depressant women undergoing SSRIs treatment: a double-blinded randomized controlled trial
Hashemi-Mohammadabad, N., Taghavi, S.-A., Lambert, N., Moshtaghi, R., Bazarganipour, F., & Sharifi, M. (2024) · BMC Psychiatry · doi:10.1186/s12888-023-05429-w · Cited by 20
The Effect of Gepirone-ER in the Treatment of Sexual Dysfunction in Depressed Men
Fabre, L. F., Clayton, A. H., Smith, L. C., Goldstein, I., & Derogatis, L. R. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02624.x · Cited by 18
Sexual function improves as depressive symptoms decrease during treatment with escitalopram: results of a naturalistic study of patients with major depressive disorder
Weber, S., Frøkjær, V. G., Armand, S., Nielsen, J. H., Knudsen, G. M., Jørgensen, M. B., Stenbæk, D. S., & Giraldi, A. G. E. (2023) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdac016 · Cited by 17
Understanding Excessive Crying in Neurologic Disorders: Nature, Pathophysiology, Assessment, Consequences, and Treatment
Mark, R. E., van Hoek, A., & Vingerhoets, A. J. J. M. (2008) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e31816be8f8 · Cited by 16
Fluoxetine Chronic Treatment Inhibits Male Rat Sexual Behavior by Affecting Both Copulatory Behavior and the Genital Motor Pattern of Ejaculation
Hueletl-Soto, M. E., Carro-Juárez, M., & Rodrı́guez–Manzo, G. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02339.x · Cited by 17
Effect of Ascorbic Acid on Mental Depression Drug Therapy: Clinical Study
Aburawi, S. M. (2014) · Journal of Psychology & Psychotherapy · doi:10.4172/2161-0487.1000131 · Cited by 17
Psychopathology and Psychopharmacology in the Infertile Patient
Williams, K. E., & Zappert, L. N. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511547263.008 · Cited by 17
The association between erectile dysfunction, depressive symptoms and testosterone levels among middle-aged men
Suija, K., Kerkelä, M., Rajala, U., Jokelainen, J. J., Laakso, M., Härkönen, P. K., Keinanen-Kiukaanniemi, S. M., & Timonen, M. (2014) · Scandinavian Journal of Public Health · doi:10.1177/1403494814545103 · Cited by 16
“[24] Gregorian RS, Golden KA, Bahce A, et al.”
Background
Communicating with older adults about sexual issues: How are these issues handled by physicians with and without training in human sexuality?
Levkovich, I., Gewirtz‐Meydan, A., & Ayalon, L. (2020) · Health & Social Care in the Community · doi:10.1111/hsc.13172 · Cited by 19
“K E Y W O R D S aging, health aging, physicians, sexuality Although psychological factors such as depression and anxiety can influence sexual functioning at any age, these factors become more prevalent with ageing (Gregorian et al., 2002).”
Background
Management and rehabilitation of neurologic patients with sexual dysfunction
Basson, R. J., & Bronner, G. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63247-0.00024-9 · Cited by 16
SSRI-Related Modulation of Sexual Functioning is Predicted by Pre-treatment Resting State Functional Connectivity in Healthy Men
Metzger, C. D., Walter, M., Graf, H., & Abler, B. (2013) · Archives of Sexual Behavior · doi:10.1007/s10508-013-0103-3 · Cited by 15
“Decreased sexualdesire and interest in sexual activity along with erectile dysfunction are reported in as much as 60 % of the cases (Gregorian et al., 2002) with the highest rates of up to 64 % observed under paroxetine (Clayton et al., 2002), which is one of the frequently prescribed SSRIs.”
Background
Sexual Dysfunction in Patients with Multiple Sclerosis from Argentina: What are the Differences Between Women and Men?
Contentti, E. C., Pettinicchi, J. P., Caride, A., & López, P. A. (2019) · Sexuality and Disability · doi:10.1007/s11195-019-09603-5 · Cited by 17
Erectile Dysfunction in 45-Year-Old Heterosexual German Men and Associated Lifestyle Risk Factors and Comorbidities: Results from the German Male Sex Study
Hallanzy, J., Kron, M., Goethe, V. E., Köhn, F., Schmautz, M., Arsov, C., Hadaschik, B. A., Imkamp, F., Gschwend, J. E., & Herkommer, K. (2019) · Sexual Medicine · doi:10.1016/j.esxm.2018.11.004 · Cited by 15
Daily male exposure attenuates estrous cycle disruption by fluoxetine
Sarkar, J., Hiegel, C., Maswood, N., & Uphouse, L. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.12.011 · Cited by 14
Sexual Health Competence of International Medical Graduate Psychiatric Residents in the United States
Sciolla, A., Ziajko, L. A., & Salguero, M. L. (2010) · Academic Psychiatry · doi:10.1176/appi.ap.34.5.361 · Cited by 14
“function in 30% to 60% of patients (15).”
Background
Clinical utility of desvenlafaxine 50 mg/d for treating MDD: a review of two randomized placebo-controlled trials for the practicing physician
Reddy, S., Kane, C. P., Pitrosky, B., Musgnung, J. J., Ninan, P. T., & Guico‐Pabia, C. J. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990903408678 · Cited by 14
Sexual Dysfunction Induced by Antidepressants—A Pharmacovigilance Study Using Data from VigiBaseTM
Zeiss, R., Malejko, K., Connemann, B. J., Gahr, M., Durner, V., & Graf, H. (2024) · Pharmaceuticals · doi:10.3390/ph17070826 · Cited by 18
“This is consistent with previous research, which found an increased risk of sexual dysfunction for SSRIs in particular [31,32].”
Result
Change in symptoms of erectile dysfunction in depressed men initiating buprenorphine therapy
Cioe, P. A., Anderson, B. J., & Stein, M. D. (2013) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2013.06.004 · Cited by 13
“In the United States, SSRIs are widely used for the treatment of depression and 30–60% of patients generally report sexual dysfunction as an adverse effect of their use (Gregorian et al., 2002; Kennedy & Rizvi, 2009).”
Background
Drugs That Affect Male Sexual Function
Yang, B. K., & Donatucci, C. F. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-155-0_8 · Cited by 13
Female Sexual Dysfunction in Presymptomatic Mutation Carriers and Patients with Huntington’s Disease
Kolenc, M., Kobal, J., & Podnar, S. (2017) · Journal of Huntington s Disease · doi:10.3233/jhd-160224 · Cited by 13
Drogues, médicaments et sexualité
Lévy, J. J., & Garnier, C. (2007) · Drogues santé et société · doi:10.7202/015693ar · Cited by 13
Suggesting a testing strategy for possible endocrine effects of drug metabolites
Jacobsen, N. W., Brooks, B. W., & Halling‐Sørensen, B. (2012) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2012.02.003 · Cited by 12
Use of an operant paradigm for the study of antidepressant-induced sexual dysfunction
Uphouse, L. L., Pinkston, J. W., Baade, D., Solano, C., & Onaiwu, B. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000177 · Cited by 12
“Currently available antidepressants vary in their purported mechanism of action, but most lead to some degree of sexual dysfunction (Gregorian et al., 2002; Montgomery et al., 2002; Segraves, 2007; Schweitzer et al., 2009).”
Background
Sexualität bei Übergewicht und Adipositas
Abrahamian, H., & Kautzky‐Willer, A. (2016) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-016-0430-9 · Cited by 12
Sexual intimacy in later life: From the perspectives of older couples in Malaysia
Minhat, H. S., Din, H. M., Hamid, T. A., & Nudin, S. S. H. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13648 · Cited by 12
Sexual function after strokes
Boller, F., Agrawal, K., & Romano, A. E. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63247-0.00016-x · Cited by 12
Neurologist-induced sexual dysfunction
Devinsky, O. (2005) · Neurology · doi:10.1212/01.wnl.0000178385.31601.e4 · Cited by 12
Safety and Efficacy of Drug Holidays for Women with Sexual Dysfunction Induced by Selective Serotonin Reuptake Inhibitors (SSRIs) Other than Fluoxetine: An Open-Label Randomized Clinical Trial
Lalegani, E., Eissazade, N., Shalbafan, M., Salehian, R., Shariat, S. V., Askari, S., Orsolini, L., & Soraya, S. (2023) · Brain Sciences · doi:10.3390/brainsci13101397 · Cited by 11
“Overall, so far, the most promising adjuvant therapy appeared to be adding bupropion at higher doses (150 mg twice daily) in women [4,5,17–27].”
Background
Preconception planning to reduce the risk of perinatal depression and anxiety disorders
Avni-Barron, O., Hoagland, K., Ford, C., & Miller, L. J. (2010) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.10.27 · Cited by 11
Effects of Antidepressant Treatment on Sexual Arousal in Depressed Women: A Preliminary fMRI Study
Yang, J.-C., Park, J., Kim, G.-W., Eun, S. J., Lee, M.-S., Han, K.-L., Chae, J., & Jeong, G. (2012) · Psychiatry Investigation · doi:10.4306/pi.2012.9.4.379 · Cited by 11
Newly diagnosed panic disorder and the risk of erectile dysfunction: A population-based cohort study in Taiwan
Wang, Y.-T., Chen, H.-H., Lin, C., Lee, S.-H., Chan, C.-H., & Huang, S. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.07.037 · Cited by 11
Antidepressants
Jennings, L. (2018) · Springer eBooks · doi:10.1007/978-3-319-74604-3_4 · Cited by 12
Post-SSRI Sexual Dysfunction: Preclinical to Clinical. Is It Fact or Fiction?
Coşkuner, E. R., Çulha, M. G., Özkan, B., & Orhan, E. (2018) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.11.004 · Cited by 12
Sexual Dysfunction in Patients with Antidepressant-treated Anxiety or Depressive Disorders: a Pragmatic Multivariable Longitudinal Study
Preeti, S., Jayaram, S., & Andrade, C. (2018) · East Asian Archives of Psychiatry · doi:10.12809/eaap181664 · Cited by 11
Involuntary Emotional Expression Disorder: Treating the Untreated
Brooks, B. (2007) · CNS Spectrums · doi:10.1017/s1092852900025980 · Cited by 15
Reproductive Toxicity Induced by Serotonin‐Norepinephrine Reuptake Inhibitors: A Pharmacovigilance Analysis From 2004 to 2023 Based on the FAERS Database
Xi, Y., Bao, Z., Guo, Q., Wang, J., Jing, Z., Di, J., & Yang, K. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70176 · Cited by 19
Aframomum melegueta prevents the ejaculatory complications of propylthiouracil-induced hypothyroidism in sexually experienced male rats: Evidence from intravaginal and fictive ejaculations
Nguimatio, F. X. K., Deeh, P. B. D., Wankeu‐Nya, M., Ngadjui, E., Kamanyi, A., Kamtchouing, P., & Watcho, P. (2019) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2019.05.001 · Cited by 10
Paroxetine inhibited the relaxations induced by EFS in mice corpus cavernosum: is it a NOS inhibition?
Kadıoğlu, M., Muci, E., Özyavuz, R., Yariş, E., Kesim, M., & Kalyoncu, N. İ. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00742.x · Cited by 10
Enquête sur la sexualité en France
Laporte, A., & Beltzer, N. (2008) · La Découverte eBooks · doi:10.3917/dec.bajos.2008.01.0509 · Cited by 10
Neurobehavioral and toxicological effects of an aqueous extract of Turnera diffusa Willd (Turneraceae) in mice
María, D.-B. A., María, V. V. R., Mayagoitia-Novales, L., Martı́nez-Mota, L., Gutiérrez‐Pérez, O., & Estrada‐Reyes, R. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.02.036 · Cited by 11
Long-term use of sertraline leads to alterations in contractility of rat isolated vas deferens
Özyavuz, R., Kalyoncu, N. İ., & Karaoglu, S. (2004) · Urological Research · doi:10.1007/s00240-003-0368-4 · Cited by 10
“other antidepressant drugs, treatment with SSRIs may be accompanied by sexual dysfunction [3, 7, 9].”
Background
Finasteride and the Uncertainties of Establishing Harms
Moore, T. J. (2015) · JAMA Dermatology · doi:10.1001/jamadermatol.2015.37 · Cited by 10
Developmental effects on hypothalamic, hypophyseal, testicular and steroidogenic patterns of sertraline-exposed male rats by accumulated doses from juvenile to puberty
ElMazoudy, R. H., El-Abd, K., Mekkawy, D., & Kamel, K. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109840 · Cited by 9
Treatment with Selective Serotonin Reuptake Inhibitors and Mirtapazine Results in Differential Brain Activation by Visual Erotic Stimuli in Patients with Major Depressive Disorder
Kim, W. K., Jin, B., Yang, W.-S., Lee, K.-U., Juh, R.-H., Ahn, K. J., Chung, Y., & Chae, J. (2009) · Psychiatry Investigation · doi:10.4306/pi.2009.6.2.85 · Cited by 9
Sexual aspects of medical practice
Bancroft, J. (2009) · Elsevier eBooks · doi:10.1016/b978-0-443-05161-6.00013-6 · Cited by 9
The epidemiology of antidepressant use in South Korea: does short-term antidepressant use affect the relapse and recurrence of depressive episodes
Kim, M. J., Kim, N., Shin, D., Rhee, S. J., Park, C. H. K., Kim, H., Cho, S. J., Lee, J. W., Kim, E. Y., Yang, B., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0222791 · Cited by 8
Self-citation
Influence de l'âge sur la santé sexuelle masculine
Seisen, T., Morgan Rouprêt, A., Costa, P., & Giuliano, F. (2012) · The French Journal of Urology · doi:10.1016/s1166-7087(12)70029-5 · Cited by 8
Spontaneous unwelcome orgasms due to pramipexole and ropinirole
Kaut, O., Asmus, F., & Paus, S. (2012) · Movement Disorders · doi:10.1002/mds.25134 · Cited by 8
Depression and antidepressant prescribing in the elderly
Herron, J. W., & Mitchell, A. (2018) · Prescriber · doi:10.1002/psb.1654 · Cited by 9
II. Antidepressants and sexual behavior: Acute fluoxetine, but not ketamine, disrupts paced mating behavior in sexually experienced female rats
Marshall, G. E., Guarraci, F. A., & Meerts, S. H. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173040 · Cited by 8
Pharmaceutical management of sexual dysfunction in men on antidepressant therapy
Bakr, A. M., El‐Sakka, A. A., & El‐Sakka, A. I. (2022) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2022.2064218 · Cited by 8
Serotonin 1A receptors and sexual behavior in a genetic model of depression
Schijven, D., Sousa, V. C., Roelofs, J., Olivier, B., & Olivier, J. D. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.12.012 · Cited by 8
“This finding was surprising as it is well-known that depression results in sexual dysfunction (Gregorian et al., 2002; Mathew and Weinman, 1982; Williams and Reynolds, 2006) a finding that is also apparent in animal models for depression (Chan et al.”
BackgroundResult
A Comparison of Orlistat Use in a Veteran Population: A Pharmacist-Managed Pharmacotherapy Weight-Loss Clinic versus Standard Medical Care
Graham, M. R., Landgraf, C. G., & Lindsey, C. C. (2003) · Journal of Pharmacy Technology · doi:10.1177/875512250301900601 · Cited by 7
Sexual function in people with multiple sclerosis: a systematic review and meta-analysis
Panah, M. Y., Oraee, S., Fekri, M., Saberian, P., Afshin, S., Vaheb, S., Shaygannejad, V., & Mirmosayyeb, O. (2025) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdaf102 · Cited by 9
Challenging Normative Orthodoxies in Depression: Huxley's Utopia or Dante's Inferno?
Cutcliffe, J. R., & Lakeman, R. (2009) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2009.06.004 · Cited by 7
Serotonin and Sexual Dysfunction
Shankar, G. (2014) · Journal of Autacoids · doi:10.4172/2161-0479.1000e129 · Cited by 7
Tablets or Talk? A Critical Review of the Literature Comparing Antidepressants and Counseling for Treatment of Depression
Hagen, B. F., Wong‐Wylie, G., & Pijl, E. M. (2010) · Journal of Mental Health Counseling · doi:10.17744/mehc.32.2.al84578m4137768k · Cited by 7
“For example, while antidepressant package inserts state that rates of sexual side effects range ftom 5% to 15%, actual prevalence rates range from 30% to 60% (Consumer Reports, 2004; Gregorian et al., 2002).”
Background
Fluoxetine prevents 8-OH-DPAT-induced hyperphagia in Fischer inbred rats
Miryala, C. S. J., Maswood, N., & Uphouse, L. L. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.014 · Cited by 7
Sexualität und Pharmakotherapie
Hartmann, U. H., & Rüffer-Hesse, C. (2006) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-007-0113-9 · Cited by 7
“Trotz ihrer zum Teil heterogenen Ergebnisse wird deutlich, dass sexuelle Dysfunktionen zu den häufigsten Nebenwirkungen der SSRIs zählen, die zwischen 35 und 60 % der Patienten betreffen [3].”
Background
Mental Health
Procter, N. G., Hamer, H. P., McGarry, D. E., Wilson, R. L., & Froggatt, T. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316718278 · Cited by 6
Hormone replacement with 17β-estradiol plus dihydrotestosterone restores male sexual behavior in rats treated neonatally with clomipramine.
Limón-Morales, O., Soria-Fregozo, C., Arteaga-Silva, M., González, M. H., Vázquez-Palacios, G., & Bonilla-Jaime, H. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.09.014 · Cited by 6
Metabolische Nebenwirkungen von Psychopharmaka
Connemann, B. J., Cabanis, M., Denoix, N., & Gahr, M. (2016) · Nervenheilkunde · doi:10.1055/s-0037-1616420 · Cited by 6
Schlafstörungen und Beeinträchtigungen des Schlafs als Nebenwirkungen von Psychopharmaka: eine Bewertung der Daten aus Fachinformationen
Gahr, M., Connemann, B. J., Zeiss, R., & Fröhlich, A. (2018) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-0043-119800 · Cited by 6
ASSESSMENT
Covington, S. N., & Burns, L. H. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511547263.007 · Cited by 6
Understanding Women's Sexual Health: A Case-Based Approach
Marnach, M. L., & Casey, P. M. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.12.1382 · Cited by 6
Drugs that cause sexual dysfunction
Smith, S. M. (2004) · Psychiatry · doi:10.1383/psyt.3.2.20.30309 · Cited by 6

Authors: Gregorian, R. S., Golden, K. A., Bahce, A., Goodman, C., Kwong, W. J., & Khan, Z. M.
Affiliations: Lewin Group (United States) (US)
Icahn School of Medicine at Mount Sinai (US)
GlaxoSmithKline (United States) (US)
GlaxoSmithKline (United Kingdom) (GB)
Corresponding author: Goodman, Clifford
ORCID: Goodman, Clifford
Venue: Annals of Pharmacotherapy
Publisher: SAGE Publications
Published: 2002-10
Volume: 36
Issue: 10
Pages: 1577-1589
ISSN: 0012-6578 (ISSN-L)
1060-0280
1542-6270
DOI: 10.1345/aph.1a195
OpenAlex: W2171466849
Cited by: 320
References: 71
Citations by year: 2026: 3 · 2025: 5 · 2024: 11 · 2023: 9 · 2022: 18 · 2021: 4 · 2020: 9 · 2019: 10 · 2018: 15 · 2017: 6 · 2016: 12 · 2015: 13 · 2014: 17 · 2013: 22 · 2012: 22
FWCI: 7.68
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Annals of Pharmacotherapy (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: antidepressant-induced sexual dysfunction, selective serotonin reuptake inhibitors, adverse drug reactions, fluoxetine, sertraline, paroxetine, bupropion, nefazodone, mirtazapine, depression treatment, medication adherence
MeSH terms: Antidepressive Agents, Clinical Trials as Topic, Depressive Disorder, Female, Humans, Libido, Male, Selective Serotonin Reuptake Inhibitors, Sexual Dysfunctions, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Antidepressant-Induced Sexual Dysfunction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks