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Cited by 584

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Proposal for a New Tool to Evaluate Drug Interaction Cases

Horn, John R, Hansten, Philip D, Chan, Lingtak-Neander·2007·Annals of Pharmacotherapy

Abstract

The assessment of causation for a potential drug interaction requires thoughtful consideration of the properties of both the object and precipitant drugs, patient-specific factors, and the possible contribution of other drugs that the patient may be taking. The Naranjo nomogram was designed to evaluate single-drug adverse events, not drug–drug interactions. Several of the questions on the Naranjo nomogram do not apply to potential drug–drug interactions, while others do not specify object or precipitant drug. Nevertheless, it has been inappropriately used to evaluate drug–drug interactions. The Drug Interaction Probability Scale (DIPS) was developed to provide a guide to evaluating drug interaction causation in a specific patient. It is intended to be used to assist practitioners in the assessment of drug interaction–induced adverse outcomes. The DIPS uses a series of questions relating to the potential drug interaction to estimate a probability score. An accurate assessment using the DIPS requires knowledge of the pharmacologic properties of both the object and precipitant drugs. Inadequate knowledge of either the drugs involved or the basic mechanisms of interaction will be a limitation for some users. The DIPS can also serve as a guide in the preparation of articles describing case reports of drug interactions, as well as in the evaluation of published case reports.

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Metadata

Authors
Horn, J. R., Hansten, P. D., & Chan, L.-N.
Venue
Annals of Pharmacotherapy
Published
2007-04
Volume
41
Issue
4
Pages
674-680
ISSN
  • 0012-6578 (ISSN-L)
  • 1060-0280
  • 1542-6270
OpenAlex
W2152558468
Cited by
584
References
10
FWCI
52.91
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Proposal for a New Tool to Evaluate Drug Interaction Cases. https://app.cochat.ai/papers/10.1345/aph.1h423
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Horn, J. R., Hansten, P. D., & Chan, L.-N. (2007). Proposal for a New Tool to Evaluate Drug Interaction Cases. Annals of Pharmacotherapy. https://doi.org/10.1345/aph.1h423

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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