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Differentiation of mitochondrial DNA and Y chromosomes in Russian populations.

Malyarchuk, Boris, Derenko, Miroslava, Grzybowski, Tomasz, Lunkina, Arina, Czarny, Jakub, Rychkov, Serge, Morozova, Irina, Denisova, Galina, Miscicka-Sliwka, Danuta·2004·Human Biology

Abstract

The genetic composition of the Russian population was investigated by analyzing both mitochondrial DNA (mtDNA) and Y-chromosome loci polymorphisms that allow for the different components of a population gene pool to be studied, depending on the mode of DNA marker inheritance. mtDNA sequence variation was examined by using hypervariable segment I (HVSI) sequencing and restriction analysis of the haplogroup-specific sites in 325 individuals representing 5 Russian populations from the European part of Russia. The Y-chromosome variation was investigated in 338 individuals from 8 Russian populations (including 5 populations analyzed for mtDNA variation) using 12 binary markers. For both uniparental systems most of the observed haplogroups fell into major West Eurasian haplogroups (97.9% and 99.7% for mtDNA and Y-chromosome haplogroups, respectively). Multidimensional scaling analysis based on pairwise F(ST) values between mtDNA HVSI sequences in Russians compared to other European populations revealed a considerable heterogeneity of Russian populations; populations from the southern and western parts of Russia are separated from eastern and northern populations. Meanwhile, the multidimensional scaling analysis based on Y-chromosome haplogroup F(ST) values demonstrates that the Russian gene pool is close to central-eastern European populations, with a much higher similarity to the Baltic and Finno-Ugric male pools from northern European Russia. This discrepancy in the depth of pene…

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Crossref · 10.1353/hub.2005.0021

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Metadata

Authors
Malyarchuk, B., Derenko, M., Grzybowski, T., Lunkina, A., Czarny, J., Rychkov, S., Morozova, I., Denisova, G., & Miscicka-Sliwka, D.
Venue
Human Biology
Publisher
Project MUSE
Published
2004
Volume
76
Issue
6
Pages
877-900
ISSN
1534-6617
Cited by
59
References
2
Language
en

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