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Cited by 150HIV-related health complications and treatmentsBone health and osteoporosis researchHIV/AIDS drug development and treatment

BMD Is Reduced in HIV-Infected Men Irrespective of Treatment

Amiel, C, Ostertag, A, Slama, L, Baudoin, C, N'Guyen, T, Lajeunie, E, Neit-Ngeilh, L, Rozenbaum, W +1 more·2004·Journal of Bone and Mineral Research
DOI 10.1359/jbmr.0301246
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Abstract

Osteoporosis has be reported to be a complication of active antiretroviral therapy of HIV infection. We studied 148 HIV-infected men stratified according to their treatment. Our data show that these patients have an average 9% decreased BMD, irrespective of their treatment. Low body mass index and high resorption markers were associated with low bone density. Introduction: Osteoporosis has been reported in HIV-infected (HIV+) patients, and it has been suggested that it may be linked to protease-inhibitor treatments (PI). Materials and Methods: To assess this risk and to investigate its putative link with treatments, we compared the bone density of HIV+ men, who were either receiving treatment (including PI [PI+], n = 49; without PI [PI−], n = 51) or untreated (UT, n = 48). We included 81 age-matched control HIV-negative (HIV−) males (age, 40 ± 8 years). Results: BMD adjusted for age (Z-score) was lower in the HIV+ patients at the lumbar spine (HIV+: −1.08 ± 1.21, HIV−: −0.06 ± 1.26, p < 0.001) and the femoral neck (HIV+: −0.39 ± 1.05, HIV−: 0.25 ± 0.87, p < 0.001). The prevalence of osteoporosis was 16% in HIV+ and 4% in HIV− subjects (p < 0.01). In the HIV+ subjects, the Z-score was correlated only to body mass index (r = 0.27 at lumbar spine and 0.35 at femoral neck). Untreated HIV+ patients had a negative Z-score (−0.82 ± 1.15 for the lumbar spine), which was not different from the one of treated HIV+ patients. In the PI+ and PI− groups, the Z-score did not depend on the presence of lipodystrophy or the proportion of fat in the abdomen and legs measured by DXA. Markers of bone remodeling were measured in the 132 HIV+ and 35 HIV− subjects. Compared with controls, HIV+ patients had lower bone alkaline phosphatase and higher urinary cross-laps/Cr, which was negatively correlated with the Z-score at both the femoral neck (r = −0.22) and lumbar spine (r = −0.21). TNFα was increased in untreated compared with treated HIV+ subjects and was not correlated to the Z-score. Conclusion: Our cross-sectional study does not show any deleterious effect of the treatment but does indicate a decrease in bone density in HIV+ patients irrespective of the treatment. This low bone density is in part related to the low body weight and is associated with increased bone resorption.

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  • There is divergence as to whether reduced BMD in HIV patients is due to HIV retrovirus or protease inhibitor therapy.

    “HIV patients are consistently reported to display reduced BMD and increased risk of developing osteoporosis, although there is some divergence as to whether this phenomenon occurs due to the HIV retrovirus or protease inhibitor therapy (Tebas et al, 2000; Bruera et al, 2003; Amiel et al, 2004; Brown & Qaqish, 2006).”

    From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Amiel et al, 2004

  • HIV patients display reduced BMD and increased risk of osteoporosis.

    “HIV patients are consistently reported to display reduced BMD and increased risk of developing osteoporosis, although there is some divergence as to whether this phenomenon occurs due to the HIV retrovirus or protease inhibitor therapy (Tebas et al, 2000; Bruera et al, 2003; Amiel et al, 2004; Brown & Qaqish, 2006).”

    From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Amiel et al, 2004

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Authors
Amiel, C., Ostertag, A., Slama, L., Baudoin, C., N'Guyen, T., Lajeunie, E., Neit-Ngeilh, L., Rozenbaum, W., & De Vernejoul, M.
Affiliations
  • Hôpital Tenon (FR)
  • Inserm (FR)
  • Department of Infectious Disease, Hôpital Tenon, Paris, France
  • INSERM U349, Department of Rheumatology and Biochemistry, Hôpital Lariboisière, Paris, France
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
2004-03-01
Volume
19
Issue
3
Pages
402-409
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1359/jbmr.0301246
OpenAlex
W2090569295
Cited by
150
References
30
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 11
FWCI
11.04
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Styrelsen för Internationellt Utvecklingssamarbete
Topics
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords
HIV infection, osteoporosis, bone mineral density, antiretroviral therapy, protease inhibitors, lipodystrophy, body mass index, bone resorption markers, bone formation markers, alkaline phosphatase, untreated HIV, HIV-positive men, lumbar spine, femoral neck, bone remodeling, HIV-associated bone loss
MeSH terms
Adult, Humans, Lipodystrophy, Male, Middle Aged, Osteoporosis, Protease Inhibitors, Biomarkers, Bone Density, HIV Infections, Fractures, Bone

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