Increased Prevalence of Radiological Spinal Deformities in Adult Patients With GH Deficiency: Influence of GH Replacement Therapy
Open accessAbstract
This cross-sectional study shows that a high number of untreated adult patients with GHD develop radiological vertebral deformities. Patients undergoing GH replacement treatment showed a significantly lower prevalence of vertebral deformities versus treated patients in the presence of similar BMD, as assessed by DXA. Introduction: In this cross-sectional study, we investigated whether the prevalence and degree of spinal deformities in adults with growth hormone deficiency (GHD) were related to the age of patients, degree of bone turnover, BMD, and recombinant human GH (rhGH) replacement therapy. Materials and Methods: One hundred seven adult hypopituitary patients (67 males and 40 females; mean age, 47 years; range: 16–81 years) with severe GHD and 130 control subjects (39 males, 91 females; mean age: 58.9 years; range: 26–82 years) were evaluated for BMD (DXA) and vertebral deformities (quantitative morphometric analysis). At study entry, 65 patients were on replacement therapy with rhGH, whereas 42 patients had never undergone rhGH. Results: Vertebral fractures were significantly more frequent in GHD patients versus control subjects (63.6% versus 37.7%; χ2 15.7; p < 0.001). The fracture prevalence, as well as the fracture number, was significantly higher in untreated versus treated patients (78.6% versus 53.8%; χ2: 6.7; p = 0.009), although the two groups of patients did not show any significant difference in median T score. In untreated GHD patients, the prevalence of vertebral deformities was correlated with T score (p = 0.002) and duration of disease (p = 0.003). In treated GHD patients, the prevalence of spinal deformities was correlated only with the timing of the beginning of rhGH replacement. Conclusions: This cross-sectional study reports high prevalence of vertebral radiological deformities in adult patients with untreated GHD. The replacement treatment of GHD leads to a significant decrease in fracture rate.
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GH replacement therapy may reduce the risk of fracture in patients with hypopituitarism and GHD.
“Some studies suggest that GH replacement therapy may reduce the risk of fracture in patients with hypopituitarism and GHD [51, 59].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [59]
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Cites
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The effect of hypopituitarism on life expectancy.
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Research works printed but not linked: 2
- Davidson P, Milne R, Chase D, Cooper C 2004 Growth hor- mone replacement in adults and bone mineral density: A sys- tematic review and meta-analysis. Clin Endocrinol (Oxf) 60:92-98.
- Growth Hormone Research Society 1998 Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the Growth Hormone Re- search Society Workshop on Adult Growth Hormone Defi- ciency. J Clin Endocrinol Metab 83:379-381.
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- Authors
- Mazziotti, G., Bianchi, A., Bonadonna, S., Nuzzo, M., Cimino, V., Fusco, A., De Marinis, L., & Giustina, A.
- Affiliations
- University of Brescia (IT)
- Università Cattolica del Sacro Cuore (IT)
- Endocrinology, Catholic University, Rome, Italy
- Corresponding author
- Giustina, Andrea
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04-01
- Volume
- 21
- Issue
- 4
- Pages
- 520-528
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2002688486
- Cited by
- 141
- References
- 2
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 9 · 2014: 17 · 2013: 6 · 2012: 6
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Brescia
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Scoliosis diagnosis and treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- growth hormone deficiency, spinal deformity, vertebral fractures, bone mineral density, hypopituitarism, fracture prevalence, bone turnover
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Radiography, Risk Factors, Spine, Bone Density, Prevalence, Human Growth Hormone, Hormone Replacement Therapy, Fractures, Bone
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