Vertebral Fractures in Patients With Acromegaly: A 3-Year Prospective Study
Abstract
Context Cross-sectional studies showed an elevated prevalence of vertebral fractures in acromegaly. However, no data are available on incident vertebral fractures in this clinical setting. Objective The objective of the study was to investigate the incidence and risk factors of vertebral fractures in patients with acromegaly. Design This was a 3-year prospective study. Setting The study was conducted at referral centers. Subjects Eighty-eight patients with acromegaly (33 females, 55 males; mean age 50 years, range 21-85 years) and 106 control subjects, matched for sex and age (43 females and 63 males, mean age 55 years, range 33-79 years), attending outpatient bone clinics participated in the study. Main measures Patients and control subjects were evaluated for the incidence of vertebral fractures using a quantitative morphometric approach on spine x-ray, which was performed at baseline and after 3 years of follow-up. At the same time points, patients with acromegaly were also evaluated for bone mineral density with dual-energy X-ray absorptiometry at lumbar spine and femoral neck. Results After a 3-year follow-up, 37 patients with acromegaly (42.0%) and 4 control subjects (3.8%) experienced incident vertebral fractures (P Conclusions This prospective study demonstrates a high rate of incident vertebral fractures both in patients with active and controlled acromegaly.
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Conflicting data on bone mineral density in acromegaly might be related to gonadal status, different skeletal sites measured, various techniques employed, subject's gender, age, and activity of the disease.
“Conflicting data on bone mineral density might be related to gonadal status, different skeletal sites being measured, various techniques employed, subject's gender, age, and activity of the disease [28, 36, 38].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [38]
In a prospective study, the incidence of vertebral fractures was significantly higher in patients with active acromegaly compared with those who had controlled or cured acromegaly at the beginning of the study.
“In a prospective study the incidence of VFs was significantly higher in patients with active disease as compared with those who had controlled/cured acromegaly at the beginning of the study [38].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [38]
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Treatment of acromegaly increases BMD but reduces trabecular bone score: a longitudinal study
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Self-citationModern approach to resistant acromegaly
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Self-citationHigh Prevalence of Radiological Vertebral Fractures in Patients With TSH-Secreting Pituitary Adenoma
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Pituitary Disorders and Osteoporosis
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Acromegaly: Clinical Care in Central and Eastern Europe, Israel, and Kazakhstan
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Musculoskeletal disease in acromegaly—a population-based registry study
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Update on vertebral fractures in pituitary diseases: from research to clinical practice
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- Authors
- Mazziotti, G., Bianchi, A., Porcelli, T., Mormando, M., Maffezzoni, F., Cristiano, A., Giampietro, A., De Marinis, L., & Giustina, A.
- Affiliations
- Azienda Ospedaliera Carlo Poma (IT)
- Università Cattolica del Sacro Cuore (IT)
- University of Brescia (IT)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-08
- Volume
- 98
- Issue
- 8
- Pages
- 3402-3410
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2142417862
- Cited by
- 172
- References
- 59
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 17 · 2023: 10 · 2022: 14 · 2021: 15 · 2020: 17 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 16 · 2013: 3
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- acromegaly, vertebral fractures, fracture incidence, fracture risk factors, hypogonadism, femoral neck bone mineral density, bone mineral density, disease control, osteoporosis
- MeSH terms
- Acromegaly, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Prospective Studies, Bone Density, Logistic Models, Spinal Fractures
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