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Microarchitecture Influences Microdamage Accumulation in Human Vertebral Trabecular Bone
Open accessAbstract
It has been suggested that accumulation of microdamage with age contributes to skeletal fragility. However, data on the age-related increase in microdamage and the association between microdamage and trabecular microarchitecture in human vertebral cancellous bone are limited. We quantified microdamage in cancellous bone from human lumbar (L2) vertebral bodies obtained from 23 donors 54–93 yr of age (8 men and 15 women). Damage was measured using histologic techniques of sequential labeling with chelating agents and was related to 3D microarchitecture, as assessed by high-resolution μCT. There were no significant differences between sexes, although women tended to have a higher microcrack density (Cr.Dn) than men. Cr.Dn increased exponentially with age (r = 0.65, p < 0.001) and was correlated with bone volume fraction (BV/TV; r = −0.55; p < 0.01), trabecular number (Tb.N; r = −0.56 p = 0.008), structure model index (SMI; r = 0.59; p = 0.005), and trabecular separation (Tb.Sp; r = 0.59; p < 0.009). All architecture parameters were strongly correlated with each other and with BV/TV. Stepwise regression showed that SMI was the best predictor of microdamage, explaining 35% of the variance in Cr.Dn and 20% of the variance in diffuse damage accumulation. In addition, microcrack length was significantly greater in the highest versus lowest tertiles of SMI. In conclusion, in human vertebral cancellous bone, microdamage increases with age and is associated with low BV/TV and a rod-like trabecular architecture.
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More microdamage is found in regions with low volume fraction and high SMI, indicating a predominance of trabecular rods.
“For example, more microdamage is found in regions with low volume fraction and high SMI—indicating a predominance of trabecular rods (110, 111).”
From Bone Mechanical Properties in Healthy and Diseased States (2018) · cites this paper as [111]
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Bone Mechanical Properties in Healthy and Diseased States
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Metadata
- Authors
- Arlot, M. E., Burt-Pichat, B., Roux, J.-P., Vashishth, D., Bouxsein, M. L., & Delmas, P. D.
- Affiliations
- Inserm (FR)
- Inserm Research Unit 831, Université de Lyon, Lyon, France
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Bouxsein, Mary L
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-01
- Volume
- 23
- Issue
- 10
- Pages
- 1613-1618
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- PMC
- PMC3276353
- OpenAlex
- W2103186475
- Cited by
- 89
- References
- 45
- Citations by year
- 2026: 3 · 2025: 7 · 2023: 4 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG020618)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR053986)
- National Center for Research Resources (S10RR017868)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Social Sciences › Arts and Humanities › Archeology (arts and humanities) › Forensic Anthropology and Bioarchaeology Studies
- Keywords
- microdamage, trabecular bone microarchitecture, vertebral cancellous bone, microcracks, structure model index, bone volume fraction, trabecular number, trabecular separation, sex differences, diffuse damage
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Spine, Reproducibility of Results, Bone Density
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