The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling
Abstract
Cardiotrophin (CT-1) signals through gp130 and the LIF receptor (LIFR) and plays a major role in cardiac, neurological, and liver biology. We report here that CT-1 is also expressed within bone in osteoclasts and that CT-1 is capable of increasing osteoblast activity and mineralization both in vitro and in vivo. Furthermore, CT-1 stimulated CAAT/enhancer-binding protein-δ (C/EBPδ) expression and runt-related transcription factor 2 (runx2) activation. In neonate CT-1−/− mice, we detected low bone mass associated with reduced osteoblasts and many large osteoclasts, but increased cartilage remnants within the bone, suggesting impaired resorption. Cultured bone marrow (BM) from CT-1−/− mice generated many oversized osteoclasts and mineralized poorly compared with wildtype BM. As the CT-1−/− mice aged, the reduced osteoblast surface (ObS/BS) was no longer detected, but impaired bone resorption continued resulting in an osteopetrotic phenotype in adult bone. CT-1 may now be classed as an essential osteoclast-derived stimulus of both bone formation and resorption.
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“Several osteoclast-derived factors released into the BRC have been identified and validated in genetically modified mouse models. These factors include cardiotrophin-1 (CT-1),228 S1P,229 Wnt10B, BMP6,230 collagen triple helix repeat-containing 1 (CTHRC1),231 complement factor 3a (C3a),232 and leukemia inhibitory factor (LIF).233”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [228]
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Cites
Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.
Poli, V., Balena, R. F., Fattori, E., Markatos, A., Yamamoto, M., Tanaka, H., Ciliberto, G., Rodan, G. A., & Costantini, F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06368.x · Cited by 745
Osteoclast-derived activity in the coupling of bone formation to resorption
Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 661
Self-citationWare, C. B., Horowitz, M. C., Renshaw, B. R., Hunt, J. S., Liggitt, D., Koblar, S. A., Gliniak, B., McKenna, H. J., Papayannopoulou, T., Thoma, B., et al. (1995) · Development · doi:10.1242/dev.121.5.1283 · Cited by 589
Horwood, N. J., Elliott, J., Martin, T. J., & Gillespie, M. T. (1998) · Endocrinology · doi:10.1210/endo.139.11.6433 · Cited by 456
Self-citationUdagawa, N., Takahashi, N., Katagiri, T., Tamura, T., Wada, S., Findlay, D. M., Martin, T. J., Hirota, H., Taga, T., Kishimoto, T., et al. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1461 · Cited by 410
Self-citationKalajzić, I., Kalajzić, Ž., Kaliterna, M., Gronowicz, G., Clark, S. H., Lichtler, A. C., & Rowe, D. W. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.15 · Cited by 392
Calvi, L. M., Sims, N. A., Hunzelman, J. L., Knight, M. C., Giovannetti, A., Saxton, J. M., Kronenberg, H. M., Baron, R., & Schipani, E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11296 · Cited by 388
Self-citationSims, N. A., Dupont, S., Krust, A., Clément-Lacroix, P., Minet, D., Resche-Rigon, M., Gaillard-Kelly, M., & Baron, R. (2002) · Bone · doi:10.1016/s8756-3282(01)00643-3 · Cited by 354
Self-citationRole of the CCAAT Enhancer Binding Proteins (C/EBPs) in Adipocyte Differentiation
Lane, M. D., Tang, Q.-Q., & Jiang, M.-S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1885 · Cited by 281
Wong, P. K. K., Quinn, J. M. W., Sims, N. A., van Nieuwenhuijze, A. E. M., Campbell, I. K., & Wicks, I. P. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21537 · Cited by 271
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Research works printed but not linked: 1
- Horn, 2002, A new staining technique for undecalcified bone sections that enhances visualization of fluorochromes, J Bone Miner Res, 17, S416
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Osteoclast differentiation by RANKL and OPG signaling pathways
Udagawa, N., Koide, M., Nakamura, M., Nakamichi, Y., Yamashita, T., Uehara, S., Kobayashi, Y., Furuya, Y., Yasuda, H., Fukuda, C., et al. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01162-6 · Cited by 765
Sims, N. A., & Martin, T. J. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.215 · Cited by 745
Self-citationHan, Y., You, X., Xing, W., Zhang, Z., & Zou, W. (2018) · Bone Research · doi:10.1038/s41413-018-0019-6 · Cited by 598
Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534
Sims, N. A., & Gooi, J. H. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.07.016 · Cited by 513
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Metadata
- Authors
- Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M., Gillespie, M. T., Martin, T. J., & Sims, N. A.
- Affiliations
- St Vincents Institute of Medical Research (AU)
- The University of Melbourne (AU)
- Corresponding author
- Sims, Natalie A
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12-01
- Volume
- 23
- Issue
- 12
- Pages
- 2025-2032
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2044726772
- Cited by
- 190
- References
- 40
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 10 · 2023: 1 · 2022: 12 · 2021: 16 · 2020: 19 · 2019: 11 · 2018: 8 · 2017: 14 · 2016: 6 · 2015: 13 · 2014: 16 · 2013: 8 · 2012: 15
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- cardiotrophin-1, osteoclasts, bone remodeling, bone formation, bone resorption, osteoblast activity, mineralization, C/EBPδ, Runx2, gp130, LIF receptor, osteopenia, bone marrow
- MeSH terms
- Animals, Bone and Bones, Bone Marrow, Bone Resorption, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Osteoblasts, Osteoclasts, Transcription Factors, Cytokines, Bone Remodeling, Mice, CCAAT-Enhancer-Binding Protein-delta
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