The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Vitamin K Treatment Reduces Undercarboxylated Osteocalcin but Does Not Alter Bone Turnover, Density, or Geometry in Healthy Postmenopausal North American Women
Open accessAbstract
Low vitamin K status is associated with low BMD and increased fracture risk. Additionally, a specific menaquinone, menatetrenone (MK4), may reduce fracture risk. However, whether vitamin K plays a role in the skeletal health of North American women remains unclear. Moreover, various K vitamers (e.g., phylloquinone and MK4) may have differing skeletal effects. The objective of this study was to evaluate the impact of phylloquinone or MK4 treatment on markers of skeletal turnover and BMD in nonosteoporotic, postmenopausal, North American women. In this double-blind, placebo-controlled study, 381 postmenopausal women received phylloquinone (1 mg daily), MK4 (45 mg daily), or placebo for 12 mo. All participants received daily calcium and vitamin D3 supplementation. Serum bone-specific alkaline phosphatase (BSALP) and n-telopeptide of type 1 collagen (NTX) were measured at baseline and 1, 3, 6, and 12 mo. Lumbar spine and proximal femur BMD and proximal femur geometry were measured by DXA at baseline and 6 and 12 mo. At baseline, the three treatment groups did not differ in demographics or study endpoints. Compliance with calcium, phylloquinone, and MK4 treatment was 93%, 93%, and 87%, respectively. Phylloquinone and MK4 treatment reduced serum undercarboxylated osteocalcin but did not alter BSALP or NTX. No effect of phylloquinone or MK4 on lumbar spine or proximal femur BMD or proximal femur geometric parameters was observed. This study does not support a role for vitamin K supplementation in osteoporosis prevention among healthy, postmenopausal, North American women receiving calcium and vitamin D supplementation.
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“Its deficiency has been associated with increased risk of fragility fractures452–455, particularly in patients who are malnourished456,457.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [456]
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“In eight cases,58–65 affected trial reports contributed to the rationale for undertaking further RCTs.”
From An investigation into the impact and implications of published papers from retracted research: systematic search of affected literature (2019) · cites this paper as [60]
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3 retracted
Ishida, Y., & Kawai, S. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.05.019 · Cited by 125
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Osteoporosis Prevention, Diagnosis, and Therapy
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Bone Quality — The Material and Structural Basis of Bone Strength and Fragility
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Krämer, W. (2003) · Computational Statistics & Data Analysis · Cited by 1,858
Estimates of optimal vitamin D status
Dawson‐Hughes, B., Heaney, R. P., Holick, M. F., Lips, P. T. A. M., Meunier, P. J., & Vieth, R. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1867-7 · Cited by 1,852
Fracture Prevention With Vitamin D Supplementation
Bischoff-Ferrari, H. A., Willett, W. C., Wong, J. B., Giovannucci, E. L., Dietrich, T., & Dawson-Hughes, B. F. (2005) · JAMA · doi:10.1001/jama.293.18.2257 · Cited by 1,536
Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women.
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Research works printed but not linked: 2
- Orimo, 1992, Clinical evaluation of menatetrenone in the treatment of involutional osteoporosis-a double-blind multicenter comparative study with 1alpha hydroxyvitamin D, J Bone Miner Res, 7, S122
- Gundberg, 1998, Vitamin K status and bone health: An analysis of methods for determination of undercarboxylated osteocalcin, J Clin Endocrinol Metab, 83, 3258
Cited by
Sorted by citations
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382
Roles for Vitamin K Beyond Coagulation
Booth, S. L. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141217 · Cited by 259
Dietary supplements and disease prevention — a global overview
Rautiainen, S., Manson, J. E., Lichtenstein, A. H., & Sesso, H. D. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.54 · Cited by 252
The role of osteocalcin in human glucose metabolism: marker or mediator?
Booth, S. L., Centi, A. J., Smith, S. R., & Gundberg, C. M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.201 · Cited by 235
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
McCann, J. C., & Ames, B. N. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27930 · Cited by 223
Metadata
- Authors
- Binkley, N., Harke, J., Krueger, D., Engelke, J., Vallarta-Ast, N., Gemar, D., Checovich, M., Chappell, R., & Suttie, J.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Binkley, Neil
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06-01
- Volume
- 24
- Issue
- 6
- Pages
- 983-991
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- PMC
- PMC2683650
- OpenAlex
- W2040235605
- Cited by
- 163
- References
- 48
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 3 · 2022: 13 · 2021: 4 · 2020: 12 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 13 · 2013: 11 · 2012: 12
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eisai
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058363)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Keywords
- vitamin K supplementation, vitamin K1, menatetrenone, vitamin K2, undercarboxylated osteocalcin, bone turnover markers, bone mineral density, bone geometry, postmenopausal women, osteoporosis prevention, fracture risk, bone-specific alkaline phosphatase, calcium and vitamin D supplementation
- MeSH terms
- Alkaline Phosphatase, Double-Blind Method, Female, Humans, Vitamin K 1, Placebos, Vitamin K, Absorptiometry, Photon, Bone Density, Osteocalcin, Bone Remodeling, Postmenopause, Vitamin K 2
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