Cited by 163Vitamin K Research StudiesBone health and osteoporosis researchVitamin D Research Studies

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Vitamin K Treatment Reduces Undercarboxylated Osteocalcin but Does Not Alter Bone Turnover, Density, or Geometry in Healthy Postmenopausal North American Women

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Binkley, Neil, Harke, Judith, Krueger, Diane, Engelke, Jean, Vallarta-Ast, Nellie, Gemar, Dessa, Checovich, Mary, Chappell, Richard, Suttie, John·2009·Journal of Bone and Mineral Research

DOI 10.1359/jbmr.081254PMC PMC2683650

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Abstract

Low vitamin K status is associated with low BMD and increased fracture risk. Additionally, a specific menaquinone, menatetrenone (MK4), may reduce fracture risk. However, whether vitamin K plays a role in the skeletal health of North American women remains unclear. Moreover, various K vitamers (e.g., phylloquinone and MK4) may have differing skeletal effects. The objective of this study was to evaluate the impact of phylloquinone or MK4 treatment on markers of skeletal turnover and BMD in nonosteoporotic, postmenopausal, North American women. In this double-blind, placebo-controlled study, 381 postmenopausal women received phylloquinone (1 mg daily), MK4 (45 mg daily), or placebo for 12 mo. All participants received daily calcium and vitamin D3 supplementation. Serum bone-specific alkaline phosphatase (BSALP) and n-telopeptide of type 1 collagen (NTX) were measured at baseline and 1, 3, 6, and 12 mo. Lumbar spine and proximal femur BMD and proximal femur geometry were measured by DXA at baseline and 6 and 12 mo. At baseline, the three treatment groups did not differ in demographics or study endpoints. Compliance with calcium, phylloquinone, and MK4 treatment was 93%, 93%, and 87%, respectively. Phylloquinone and MK4 treatment reduced serum undercarboxylated osteocalcin but did not alter BSALP or NTX. No effect of phylloquinone or MK4 on lumbar spine or proximal femur BMD or proximal femur geometric parameters was observed. This study does not support a role for vitamin K supplementation in osteoporosis prevention among healthy, postmenopausal, North American women receiving calcium and vitamin D supplementation.

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RETRACTED: Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, alfacalcidol, and vitamin K in postmenopausal women with osteoporosis: The Yamaguchi Osteoporosis Prevention Study
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RETRACTED: Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients
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RETRACTED: Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease
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Authors: Binkley, N., Harke, J., Krueger, D., Engelke, J., Vallarta-Ast, N., Gemar, D., Checovich, M., Chappell, R., & Suttie, J.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Binkley, Neil
ORCID: Binkley, Neil
Checovich, Mary
Chappell, Richard
Venue: Journal of Bone and Mineral Research
Publisher: Oxford University Press (OUP)
Published: 2009-06-01
Volume: 24
Issue: 6
Pages: 983-991
ISSN: 0884-0431 (ISSN-L)
1523-4681
DOI: 10.1359/jbmr.081254
PMC: PMC2683650
OpenAlex: W2040235605
Cited by: 163
References: 48
Citations by year: 2026: 3 · 2025: 7 · 2024: 7 · 2023: 3 · 2022: 13 · 2021: 4 · 2020: 12 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 13 · 2013: 11 · 2012: 12
FWCI: 11.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Bone and Mineral Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Eisai
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058363)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Keywords: vitamin K supplementation, vitamin K1, menatetrenone, vitamin K2, undercarboxylated osteocalcin, bone turnover markers, bone mineral density, bone geometry, postmenopausal women, osteoporosis prevention, fracture risk, bone-specific alkaline phosphatase, calcium and vitamin D supplementation
MeSH terms: Alkaline Phosphatase, Double-Blind Method, Female, Humans, Vitamin K 1, Placebos, Vitamin K, Absorptiometry, Photon, Bone Density, Osteocalcin, Bone Remodeling, Postmenopause, Vitamin K 2

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Vitamin K Treatment Reduces Undercarboxylated Osteocalcin but Does Not Alter Bone Turnover, Density, or Geometry in Healthy Postmenopausal North American Women

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