Cited by 731Bone Metabolism and DiseasesBone health and osteoporosis researchSpaceflight effects on biology

The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.

Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo

Verborgt, Olivier, Gibson, Gary J., Schaffler, Mitchell B.·2000·Journal of Bone and Mineral Research

DOI 10.1359/jbmr.2000.15.1.60

Open this paper in CoChat — free account

Abstract

As a result of fatigue, bone sustains microdamage, which is then repaired by bone-remodeling processes. How osteoclastic activity is targeted at the removal of microdamaged regions of bone matrix is unknown. In the current studies, we tested the hypothesis that changes in osteocyte integrity, through the initiation of regulated cell death (apoptosis), are associated with fatigue-related microdamage and bone resorption. Ulnae of adult rats were fatigue-loaded to produce a known degree of matrix damage. Osteocyte integrity was then assessed histomorphometrically from terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate–nick end labeling (TUNEL)–stained sections to detect cells undergoing DNA fragmentation associated with apoptosis; toluidine blue–stained sections were used for secondary morphological confirmation. Ten days after loading, large numbers of TUNEL-positive osteocytes were found in bone surrounding microcracks and in bone surrounding intracortical resorption spaces (∼300% increases over controls, p < 0.005). TUNEL labeling in loaded ulnae at sites distant from microcracks or resorption foci did not differ from that in control bone. Osteocytes in toluidine blue–stained sections showed equivalent trends to TUNEL-stained sections, with significant increases in pyknotic nuclei and empty lacunae associated with microcracks and intracortical resorption spaces. TUNEL-positive osteocytes were observed around bone microdamage by 1 day after loading (p < 0.01 relative to baseline), and their number remained elevated throughout the entire experimental period. Increases in empty lacunae and decreases in normal osteocyte numbers were observed over time as well. These studies show that (1) osteocyte apoptosis is induced by bone fatigue, (2) this apoptosis is localized to regions of bone that contain microcracks, and (3) osteoclastic resorption after fatigue also coincides with regions of osteocyte apoptosis. The strong associations between microdamage, osteocyte apoptosis, and subsequent bone remodeling support the hypothesis that osteocyte apoptosis provides a key part of the activation or signaling mechanisms by which osteoclasts target bone for removal after fatigue-induced matrix injury.

Integrity signals

Registry

Crossref · 10.1359/jbmr.2000.15.1.60

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., et al. (1995) · Nature · doi:10.1038/376037a0 · Cited by 3,980
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.
Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536
Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System
RAFF, M. C., Barres, B. A., Burne, J. F., Coles, H., Ishizaki, Y., & Jacobson, M. D. (1993) · Science · doi:10.1126/science.8235590 · Cited by 1,450
Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix
Boudreau, N. J., Sympson, C. J., Werb, Z., & Bissell, M. J. (1995) · Science · doi:10.1126/science.7531366 · Cited by 1,174
Anchorage dependence, integrins, and apoptosis
Ruoslahti, E. I., & Reed, J. C. (1994) · Cell · doi:10.1016/0092-8674(94)90209-7 · Cited by 1,001
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
Enari, M., Talanian, R. V., Wrong, W. W., & Nagata, S. (1996) · Nature · doi:10.1038/380723a0 · Cited by 960
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846
Bone remodeling in response to in vivo fatigue microdamage
Burr, D. B., Martin, R. B., Schaffler, M. B., & Radin, E. L. (1985) · Journal of Biomechanics · doi:10.1016/0021-9290(85)90204-0 · Cited by 765
Self-citation

Show all 52 references

Research works printed but not linked: 3

Qiu, 1997, Osteocyte apoptosis in reaction to matrix damage in compact bone Trans, Orthop Res Soc, 22, 89
Noble, 1997, Bone loading changes the number and distribution of apoptotic osteocytes in cortical bone, J Bone Miner Res, 12, 36
Noble, 1998, Matrix microdamage and osteocyte apoptosis: A mechanism for targeting bone resorption, Bone, 23, 1128

Sorted by citations

Items 401–500 of 730

Flaplessly placed 2.4-mm mini-implants for maxillary overdentures: a prospective multicentre clinical cohort study
Doorne, L. V., Kock, L. D., Moor, A. D., Shtino, R., Bronkhorst, E. M., Meijer, G., & Bruyn, H. D. (2019) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2019.08.015 · Cited by 20
Metabolic Bone Disease
Lorenzo, J. A., CANALIS, E. M., & Raisz, L. G. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00029-8 · Cited by 20
Microdamage as a Bone Quality Component: Practical Guidelines for the Two‐Dimensional Analysis of Linear Microcracks in Human Cortical Bone
Dominguez, V. M., & Agnew, A. M. (2019) · JBMR Plus · doi:10.1002/jbm4.10203 · Cited by 19
Osteocyte apoptosis and cellular micropetrosis signify skeletal aging in type 1 diabetes
Kolibová, S. D., Wölfel, E. M., Hemmatian, H., Milovanovic, P. D., Mushumba, H., Wulff, B., Neidhardt, M., Püschel, K., Failla, A. V., Veldhuis‐Vlug, A. G., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.02.037 · Cited by 21
Exercise improves subchondral bone microenvironment through regulating bone-cartilage crosstalk
Zhang, S., Li, T., Yao, F., Zhang, K., Zou, J., Weng, X., Yuan, Y. J., & Zhang, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1159393 · Cited by 26
The influence of mechanical stimulation on osteoclast localization in the mouse maxilla: bone histomorphometry and finite element analysis
Fujiki, K., Aoki, K., Marcián, P., Borák, L., Hudieb, M., Ohya, K., Igarashi, Y., & Wakabayashi, N. (2012) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-012-0401-z · Cited by 19
Regulation of bone resorption and mineral homeostasis by osteocytes
Pajevic, P. D. (2009) · IBMS BoneKEy · doi:10.1138/20090363 · Cited by 23
The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation
Mulcahy, L., Curtin, C. M., McCoy, R., O’Brien, F. J., Taylor, D. M., Lee, T., & Duffy, G. P. (2015) · European Cells and Materials · doi:10.22203/ecm.v030a19 · Cited by 19
Development of an in vivo bone fatigue damage model using axial compression of the rabbit forelimb
Buettmann, E. G., & Silva, M. J. (2016) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2016.08.020 · Cited by 19
Nomenclature, classification, and documentation of catastrophic fractures and associated preexisting injuries in racehorses
Stover, S. M. (2017) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638717692846 · Cited by 19
Childhood cancer chemotherapy–induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals
Su, Y., Chen, K., Hassanshahi, M., Tang, Q., Howe, P. R. C., & Xian, C. J. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13380 · Cited by 20
Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells
Liu, S., Li, Z., Xu, S., Xu, L., Yang, M., & Ni, G. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8797 · Cited by 19
Tissue Engineering and Regenerative Medicine Therapies for Cell Senescence in Bone and Cartilage
Zhang, Q., Nettleship, I., Schmelzer, E., Gerlach, J. C., Zhang, X., Wang, J., & Liu, C. (2019) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2019.0215 · Cited by 19
Spatiotemporal characterization of microdamage accumulation and its targeted remodeling mechanisms in diabetic fatigued bone
Liu, X., Li, W., Cai, J., Yan, Z., Shao, X., Xie, K., Guo, X.-D. E., Luo, E., & Jing, D. (2019) · The FASEB Journal · doi:10.1096/fj.201902011rr · Cited by 19
Osteocytes in the pathogenesis of osteoporosis
Ikeda, K. (2008) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2008.00481.x · Cited by 19
Surface microcracks signal osteoblasts to regulate alignment and bone formation
Shu, Y., Baumann, M. J., Case, E. D., Irwin, R., Meyer, S. E., Pearson, C. S., & McCabe, L. R. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.08.036 · Cited by 18
Trabecular architecture can remain intact for both disuse and overload enhanced resorption characteristics
Tanck, E., Ruimerman, R. R., & Huiskes, R. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2005.08.018 · Cited by 18
The Effects of Repetitive Physiologic Loading on Bone Turnover and Mechanical Properties in Adult Female and Male Rats
Yingling, V. R., Davies, S., & Silva, M. J. (2001) · Calcified Tissue International · doi:10.1007/s00223-001-0007-4 · Cited by 18
Biologic Foundations for Skeletal Tissue Engineering
Bueno, E. M., & Glowacki, J. (2011) · Synthesis lectures on tissue engineering · doi:10.1007/978-3-031-02583-9 · Cited by 21
Osteoblasts detect pericellular calcium concentration increase via neomycin-sensitive voltage gated calcium channels
Sun, X., Kishore, V., Fites, K., & Akkuş, O. (2012) · Bone · doi:10.1016/j.bone.2012.08.116 · Cited by 18
A single dose zoledronic acid enhances pin fixation in high tibial osteotomy using the hemicallotasis technique. A double-blind placebo controlled randomized study in 46 patients
Harding, A. K., Toksvig‐Larsen, S., Tägil, M., & W‐Dahl, A. (2009) · Bone · doi:10.1016/j.bone.2009.10.040 · Cited by 18
Osteocytic connexin 43 channels affect fracture healing
Chen, Y., Chen, M., Xue, T., Li, G., Wang, D., Shang, P., Jiang, J. X., & Xu, H. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28581 · Cited by 18
Photo-activated implants: a triple-blinded, split-mouth, randomized controlled clinical trial on the resistance to removal torque at various healing intervals
Puišys, A., Schlee, M., Linkevičius, T., Petrakakis, P., & Tjaden, A. (2019) · Clinical Oral Investigations · doi:10.1007/s00784-019-03041-5 · Cited by 18
Osteoblast Biology
Lian, J. B., & Stein, G. S. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50003-9 · Cited by 18
Differential Bone Adaptation to Mechanical Unloading and Reloading in Young, Old, and Osteocyte Deficient Mice
Cunningham, H. C., Orr, S. V., Murugesh, D. K., Hsia, A. W., Osipov, B., Go, L., Wu, P. H., Wong, A., Loots, G. G., Kazakia, G. J., et al. (2022) · Bone · doi:10.1016/j.bone.2022.116646 · Cited by 18
Comparison of Implant Stability Using Resonance Frequency Analysis: Osteotome Versus Conventional Drilling.
Sadeghi, R., Rokn, A. R., & Miremadi, A. (2015) · PubMed Central · Cited by 17
Histomorphology
Stout, S. D., Cole, M. E., & Agnew, A. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-809738-0.00006-5 · Cited by 21
Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of Osteoporosis
PARFITT, A. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50006-8 · Cited by 18
Osseodensification technique in crestal maxillary sinus elevation—A narrative review
Gaspar, J., Mazor, Z., & Bonfante, E. A. (2025) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13399 · Cited by 17
Two-dimensional clinorotation influences cellular morphology, cytoskeleton and secretion of MLO-Y4 osteocyte-like cells
Xu, H., Wu, J., Weng, Y., Zhang, J., & Shang, P. (2012) · Biologia · doi:10.2478/s11756-011-0161-8 · Cited by 17
Protective role of benzoselenophene derivatives of resveratrol on the induced oxidative stress in intestinal myofibroblasts and osteocytes
Domazetovic, V., Fontani, F., Tanini, D., D'Esopo, V., Viglianisi, C., Marcucci, G., Panzella, L., Napolitano, A., Brandi, M. L., Capperucci, A., et al. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.07.015 · Cited by 16
Sost Deficiency does not Alter Bone’s Lacunar or Vascular Porosity in Mice
Mosey, H., Núñez, J. A., Goring, A., Clarkin, C., Staines, K. A., Lee, P. D., Pitsillides, A. A., & Javaheri, B. (2017) · Frontiers in Materials · doi:10.3389/fmats.2017.00027 · Cited by 15
Post-extraction pain in the adjacent tooth after surgical extraction of the mandibular third molar
Park, W.-J., Park, I. K., Shin, K. S., & Choi, E. J. (2019) · Journal of Dental Anesthesia and Pain Medicine · doi:10.17245/jdapm.2019.19.4.201 · Cited by 16
Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models
Truesdell, S. L., & Saunders, M. M. (2019) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2020063 · Cited by 16
Role of the SDF-1/CXCR4 signaling pathway in cartilage and subchondral bone in temporomandibular joint osteoarthritis induced by overloaded functional orthopedics in rats
Yang, J., Li, Y., Liu, Y., Zhang, Q., Zhang, Q., Chen, J., Yan, X., & Yuan, X. H. (2020) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-020-01860-x · Cited by 16
Osteocyte apoptosis induces bone resorption and impairs the skeletal response to weightlessness
Bellido, T. (2007) · BoneKEy-Osteovision · doi:10.1138/20070272 · Cited by 16
Correlation Between Histopathologic, Arthroscopic, and Magnetic Resonance Imaging Findings in Dogs With Medial Coronoid Disease
Wavreille, V. A., Fitzpatrick, N., Drost, W. T., Russell, D., & Allen, M. J. (2014) · Veterinary Surgery · doi:10.1111/j.1532-950x.2014.12233.x · Cited by 15
Flapless cortical bone damage has no effect on medullary bone mesial to teeth being moved
Swapp, A., Campbell, P. M., Spears, R. D., & Buschang, P. H. (2015) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2014.12.022 · Cited by 15
Assessing bone's adaptive capacity around dental implants
Greenstein, G., Cavallaro, J., & Tarnow, D. P. (2013) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2013.0129 · Cited by 15
Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling
Kennedy, O. D., Lendhey, M., Mauer, P., Philip, A., Basta‐Pljakic, J., & Schaffler, M. B. (2016) · Bone · doi:10.1016/j.bone.2016.11.029 · Cited by 15
Self-citation
Microdamage in porcine alveolar bone due to functional and orthodontic loading
Verna, C., Dalstra, M., Lee, T. C., & Melsen, B. (2005) · European Journal of Morphology · doi:10.1080/09243860500095117 · Cited by 15
Cellular and Molecular Mechanotransduction in Bone
Chen, J. C., Castillo, A. B., & Jacobs, C. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00020-0 · Cited by 17
Current and emerging histomorphometric and imaging techniques for assessing age‐at‐death and cortical bone quality
Andronowski, J. M., & Cole, M. E. (2020) · Wiley Interdisciplinary Reviews Forensic Science · doi:10.1002/wfs2.1399 · Cited by 17
INTERAÇÃO CÉLULA-PROTEÍNA-IMPLANTE NO PROCESSO DE OSSEOINTEGRAÇÃO
do Nascimento, M. (2022) · Brazilian Journal of Implantology and Health Sciences · doi:10.36557/2674-8169.2022v4n2p44-59 · Cited by 15
Effects of Drugs and Chemotherapeutic Agents on Dental Implant Osseointegration: A Narrative Review
Mohammadi, A., Dehkordi, N. R., Mahmoudi, S., Rafeie, N., Sabri, H., Valizadeh, M., Poorsoleiman, T., Jafari, A., Mokhtari, A., Khanjarani, A., et al. (2022) · Current Clinical Pharmacology · doi:10.2174/2772432817666220607114559 · Cited by 14
Fatigue failure of osteocyte cellular processes: implications for the repair of bone
Dooley, C., Cafferky, D., Lee, T., & Taylor, D. M. (2014) · European Cells and Materials · doi:10.22203/ecm.v027a04 · Cited by 14
Quantification of nonlinear elasticity for the evaluation of submillimeter crack length in cortical bone
Haupert, S., Guérard, S., Mitton, D., Peyrin, F., & Laugier, P. (2015) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2015.04.013 · Cited by 14
Osteoporosis and Bone Biology
de Paula, F. J. A., Black, D. M., & Rosen, C. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00029-0 · Cited by 14
Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna
Li, H., Li, R., Han, B., Bin, Z., Bao-Hui, H., Ying-Jie, L., & Xizheng, Z. (2017) · BioMedical Engineering OnLine · doi:10.1186/s12938-017-0384-1 · Cited by 14
OsteoRheumatology: a new discipline?
Favero, M., Giusti, A., Geusens, P., Goldring, S. R., Lems, W. F., Schett, G. A., & Bianchi, G. (2015) · RMD Open · doi:10.1136/rmdopen-2015-000083 · Cited by 15
The Impact of Tannic Acid Consumption on Bone Mineralization
Winiarska‐Mieczan, A., Muszyński, S., Tomaszewska, E., Kwiecień, M., Donaldson, J., Tomczyk‐Warunek, A., & Blicharski, T. (2023) · Metabolites · doi:10.3390/metabo13101072 · Cited by 13
Multiscale computational and experimental approaches to elucidate bone and ligament mechanobiology using the ulna-radius-interosseous membrane construct as a model system
Tate, M. L. K., Tami, A., Netrebko, P., Milz, S., & Docheva, D. (2012) · Technology and Health Care · doi:10.3233/thc-2012-0686 · Cited by 13
Mechanical loading up-regulates early remodeling signals from osteocytes subjected to physical damage
Liu, C., Zhang, X., Wu, M. Y., & You, L. (2015) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2015.10.018 · Cited by 13
The Osteocyte as an Orchestrator of Bone Remodeling: An Engineer’s Perspective
van Oers, R. F. M., Klein‐Nulend, J., & Bacabac, R. G. (2014) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-014-9154-9 · Cited by 12
Influence of Dentoalveolar Ankylosis on the Biomechanical Response of a Single-rooted Tooth and Surrounding Alveolar Bone: A 3-dimensional Finite Element Analysis
Jang, Y., Hong, H.-T., Chun, H., & Roh, B. (2016) · Journal of Endodontics · doi:10.1016/j.joen.2016.07.018 · Cited by 13
Remodelling compartment in root cementum
Martins, J. F. B., Rodrigues, C. F. D., Diogo, P., Paulo, S., Palma, P., & Vale, F. (2020) · Folia Morphologica · doi:10.5603/fm.a2020.0134 · Cited by 13
Decalcification of Bone for Histochemistry and Immunohistochemistry Procedures
Hao, Z., Kalscheur, V. L., & Muir, P. (2002) · Journal of Histotechnology · doi:10.1179/014788802794792617 · Cited by 13
Mechanoregulation of osteoblast-like MG-63 cell activities by cyclic stretching
Chen, Y., Chang, M., Yao, C. J., Lai, E. H., Chang, J. Z., & Jeng, J. (2012) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2012.10.003 · Cited by 13
Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease
Daroszewska, A., Rose, L., Sarsam, N., Charlesworth, G., Prior, A., Rose, K., Ralston, S. H., & Hof, R. V. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.035576 · Cited by 13
The Role of Bone Remodeling in Preventing or Promoting Stress Fractures
Martin, R. B. (2000) · CRC Press eBooks · doi:10.1201/9781420042191-16 · Cited by 13
Ortho-silicic Acid Plays a Protective Role in Glucocorticoid-Induced Osteoporosis via the Akt/Bad Signal Pathway In Vitro and In Vivo
Gu, G., Hou, D., Jiao, G., Wu, W., Zhou, H., Wang, H., & Chen, Y. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03201-x · Cited by 12
Osteocyte: a Cellular Basis for Mechanotransduction in Bone
Gu, G., Kurata, K., Chen, Z., & Väänänen, K. (2007) · Journal of Biomechanical Science and Engineering · doi:10.1299/jbse.2.150 · Cited by 13
Reversal of loss of bone mass in old mice treated with mefloquine
Pacheco‐Costa, R., Davis, H. M., Atkinson, E. G., Dilley, J. E., Byiringiro, I., Aref, M. W., Allen, M. R., Bellido, T., & Plotkin, L. I. (2018) · Bone · doi:10.1016/j.bone.2018.06.002 · Cited by 12
The effect of human-like collagen calcium complex on osteoporosis mice
Zhu, C., Lei, H., Wang, S., Duan, Z., Fu, R., Deng, J., Fan, D., & Lv, X. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.08.011 · Cited by 12
Quantification of compact bone microporosities in the basal and alveolar portions of the human mandible using osteocyte lacunar density and area fraction of vascular canals
Tonar, Z., Khadang, I., Fiala, P., Nedorost, L., & Kochová, P. (2011) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2011.02.001 · Cited by 12
Inescapable foot shock induces a PTSD-like phenotype and negatively impacts adult murine bone
Sidles, S. J., Kelly, R. R., Kelly, K. D., Hathaway‐Schrader, J. D., Khoo, S. K., Jones, J. A., Cray, J., & LaRue, A. C. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050044 · Cited by 11
Advances in mechanobiological pharmacokinetic-pharmacodynamic models of osteoporosis treatment – Pathways to optimise and exploit existing therapies
Pivonka, P., Calvo‐Gallego, J. L., Schmidt, S., & Martínez‐Reina, J. (2024) · Bone · doi:10.1016/j.bone.2024.117140 · Cited by 11
Long-term safety of antiresorptive treatment: bone material, matrix and mineralization aspects
Misof, B. M., Fratzl‐Zelman, N., Paschalis, E. P., Roschger, P., & Klaus Klaushofer, A. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.1 · Cited by 11
Positive Effects of Qing’e Pill (青娥丸) on Trabecular Microarchitecture and its Mechanical Properties in Osteopenic Ovariectomised Mice
Shuai, B., Zhu, R., Yang, Y., Shen, L., Xu, X.-J., Ma, C., & Lü, L. (2016) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-016-2604-0 · Cited by 11
Isolation, Purification, Generation, and Culture of Osteocytes
Gooi, J. H., Chia, L. Y., Vrahnas, C., & Sims, N. A. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-8997-3_3 · Cited by 11
A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
Hambli, R., Almitani, K. H., Chamekh, A., Toumi, H., & Tavares, J. M. R. S. (2015) · Mathematical Biosciences · doi:10.1016/j.mbs.2015.01.005 · Cited by 11
Variation of the mineral density in cortical bone may serve to keep strain amplitudes within a physiological range
de Jong, W. C., van Ruijven, L. J., Brugman, P., & Langenbach, G. E. J. (2013) · Bone · doi:10.1016/j.bone.2013.04.026 · Cited by 11
Teriparatide for the rapid resolution of delayed healing of atypical fractures associated with long-term bisphosphonate use
Mastaglia, S. R., Aguilar, G. H., & Oliveri, B. (2015) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2015.0010 · Cited by 11
Histomorphometric and osteocytic characteristics of cortical bone in male subtrochanteric femoral shaft
Tong, X. F., Malo, M. K. H., Burton, I. S., Jurvelin, J. S., Isaksson, H., & Kröger, H. (2017) · Journal of Anatomy · doi:10.1111/joa.12670 · Cited by 11
Elevated Microdamage Spatially Correlates with Stress in Metastatic Vertebrae
Atkins, A., Burke, M., Samiezadeh, S., Akens, M. K., Hardisty, M., & Whyne, C. M. (2019) · Annals of Biomedical Engineering · doi:10.1007/s10439-018-02188-8 · Cited by 11
Role of mechanically damaged osteocytes in the initial phase of bone remodeling
Kurata, K., FUKUNAGA, T., MATSUDA, J., & HIGAKI, H. (2006) · International Journal of Fatigue · doi:10.1016/j.ijfatigue.2006.06.011 · Cited by 11
Cell Biology of Bone
Majeska, R. J. (2001) · CRC Press eBooks · doi:10.1201/b14263-4 · Cited by 11
The osteocyte
Klein‐Nulend, J., & Bonewald, L. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00006-3 · Cited by 11
Apoptosis in Bone Cells
Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., PARFITT, A. M., & Manolagas, S. C. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50112-8 · Cited by 21
Pannexins in the musculoskeletal system: new targets for development and disease progression
Luo, Y., Zheng, S., Xiao, W., Zhang, H., & Li, Y. (2024) · Bone Research · doi:10.1038/s41413-024-00334-8 · Cited by 13
Pathophysiology of bone remodelling cycle: Role of immune system and lipids
Parolini, C. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116844 · Cited by 10
The role of osteocytes in functional bone adaptation
Hazenberg, J. G., Lee, T. C., & Taylor, D. M. (2006) · BoneKEy-Osteovision · doi:10.1138/20060198 · Cited by 10
Computed Tomography Enhances Diagnostic Accuracy in Challenging Medial Coronoid Disease Cases: An Imaging Study in Dog Breeding Appeal Cases
Wennemuth, J., Tellhelm, B., Eley, N., & von Pückler, K. H. (2020) · Veterinary and Comparative Orthopaedics and Traumatology · doi:10.1055/s-0040-1714299 · Cited by 10
Cellular and molecular mechanotransduction in bone
Castillo, A. B., Chen, J. C., & Jacobs, C. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00014-9 · Cited by 12
Biomechanical Aspects of Bone Formation
Turner, C. H. (2004) · Springer eBooks · doi:10.1007/978-1-4471-3777-1_5 · Cited by 10
Osteocyte Biology
Bonewald, L. F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00010-8 · Cited by 14
Self-Repair of Rat Cortical Bone Microdamage after Fatigue Loading In Vivo
Wu, B., Zhang, C., Chen, B., Zhang, L., Dai, R.-C., Wu, X., Jiang, Y., & Liao, E. (2013) · International Journal of Endocrinology · doi:10.1155/2013/321074 · Cited by 10
Calcineurin/nuclear factor of activated T cells (NFAT) signaling in cobalt–chromium–molybdenum (CoCrMo) particles‐induced tumor necrosis factor‐α (TNFα) secretion in MLO‐Y4 osteocytes
Orhue, V., Kanaji, A., Caicedo, M. S., Virdi, A. S., Sumner, D. R., Hallab, N. J., Jahr, H., & Sena, K. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21458 · Cited by 10
Osteocytes in Normal Physiology and Osteoporosis
Watanabe, K., & Ikeda, K. (2010) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-010-9076-0 · Cited by 10
In vivo Labeling of Bone Microdamage in an Animal Model of Type 1 Diabetes Mellitus
Mohsin, S., Kaimala, S., AlTamimi, E. K. Y., Tariq, S., & Adeghate, E. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-53487-6 · Cited by 10
Root surface microcracks induced by orthodontic force as a potential primary indicator of root resorption
Xiao, S., Li, L., Wang, L., Wang, Y., Zhang, M., Yao, J., & Fan, Y. (2020) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2020.109938 · Cited by 10
Bone Quality: The Mechanical Effects of Microarchitecture and Matrix Properties
Day, J. S. (2005) · RePub (Erasmus University Rotterdam) · Cited by 10
Relative Energy Deficiency in Sport (RED-S) and Bone Stress Injuries
Kim, D. R., & Weber, K. M. (2023) · Operative Techniques in Sports Medicine · doi:10.1016/j.otsm.2023.151025 · Cited by 9
Multiscale effects of the calcimimetic drug, etelcalcetide on bone health of rats with secondary hyperparathyroidism induced by chronic kidney disease
Sharma, S., Kumar, S., Tomar, M. S., Chauhan, D., Kulkarni, C., Rajput, S., Sadhukhan, S., Porwal, K., Guha, R., Shrivastava, A., et al. (2024) · Bone · doi:10.1016/j.bone.2024.117126 · Cited by 9
Bone metastasis in endocrine-related cancer: unravelling invasion and destruction
Duong, H., Kafer, G. R., & Maugham, M. (2024) · Endocrine Related Cancer · doi:10.1530/erc-24-0294 · Cited by 10
Effect of Rigid Fixation on Orthodontic Finishing After Mandibular Bilateral Sagittal Split Setback: The Case for Miniplate Monocortical Fixation
Cho, H. J. (2011) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2011.09.015 · Cited by 9
Basic Bone Biology Healing During Osseointegration of Titanium Dental Implants
Soto‐Peñaloza, D., de Llano, J. J. M., Cardá, C., Diago, M. P., & Peñarrocha‐Oltra, D. (2019) · Springer eBooks · doi:10.1007/978-3-030-05546-2_2 · Cited by 9
Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo
Dolan, E. B., Tallon, D., Cheung, W.-Y., Schaffler, M. B., Kennedy, O. D., & McNamara, L. M. (2016) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0337 · Cited by 9
Self-citation
Retracted: Release of CXCL12 From Apoptotic Skeletal Cells Contributes to Bone Growth Defects Following Dexamethasone Therapy in Rats
Tang, Q., Su, Y., Fan, C., Chung, R., Hassanshahi, M., Peymanfar, Y., & Xian, C. J. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3597 · Cited by 9
Retracted
Coupling of bone formation and resorption
Sims, N. A., & Martin, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00010-5 · Cited by 11

Authors: Verborgt, O., Gibson, G. J., & Schaffler, M. B.
Affiliations: University of Antwerp (BE)
Henry Ford Health (US)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Schaffler, Mitchell B.
ORCID: Verborgt, Olivier
Schaffler, Mitchell B.
Venue: Journal of Bone and Mineral Research
Publisher: Oxford University Press (OUP)
Published: 2000-01-01
Volume: 15
Issue: 1
Pages: 60-67
ISSN: 0884-0431 (ISSN-L)
1523-4681
DOI: 10.1359/jbmr.2000.15.1.60
OpenAlex: W2020238012
Cited by: 731
References: 52
Citations by year: 2026: 10 · 2025: 18 · 2024: 9 · 2023: 23 · 2022: 23 · 2021: 21 · 2020: 29 · 2019: 38 · 2018: 31 · 2017: 28 · 2016: 31 · 2015: 39 · 2014: 30 · 2013: 40 · 2012: 32
FWCI: 10.13
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Bone and Mineral Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR044712, AR41210, R01AR041210, AR 44712)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
Keywords: osteocyte apoptosis, bone fatigue, microcracks, bone microdamage, bone remodeling, osteoclast resorption, ulna
MeSH terms: Animals, Female, Osteocytes, Stress, Physiological, Ulna, Bone Remodeling, Rats, Sprague-Dawley, In Situ Nick-End Labeling, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks