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Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties
Abstract
When a picosecond light pulse is incident on biological tissue, the temporal characteristics of the light backscattered from, or transmitted through, the sample carry information about the optical absorption and scattering coefficients of the tissue. We develop a simple model, based on the diffusion approximation to radiative transfer theory, which yields analytic expressions for the pulse shape in terms of the interaction coefficients of a homogeneous slab. The model predictions are in good agreement with the results of preliminary in vivo experiments and Monte Carlo simulations.
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Citations
Cited by
A review of the optical properties of biological tissues
Cheong, W. F., Prahl, S. A., & Welch, A. J. (1990) · IEEE Journal of Quantum Electronics · doi:10.1109/3.64354 · Cited by 2,530
Going deeper than microscopy: the optical imaging frontier in biology
Ntziachristos, V. (2010) · Nature Methods · doi:10.1038/nmeth.1483 · Cited by 1,896
Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry
Pogue, B. W., & Patterson, M. S. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2335429 · Cited by 837
Self-citationSpectroscopy and Imaging with Diffusing Light
Yodh, A., & Chance, B. (1995) · Physics Today · doi:10.1063/1.881445 · Cited by 800
Self-citationBoas, D. A., Dale, A. M., & Franceschini, M. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.011 · Cited by 721
Metadata
- Authors
- Patterson, M. S., Chance, B., & Wilson, B. C.
- Venue
- Applied Optics
- Publisher
- Optica Publishing Group
- Published
- 1989-06-15
- Volume
- 28
- Issue
- 12
- Pages
- 2331
- ISSN
- 0003-6935 (ISSN-L)
- 1539-4522
- OpenAlex
- W2050973816
- Cited by
- 2,087
- References
- 0
- FWCI
- 19.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties. https://app.cochat.ai/papers/10.1364/ao.28.002331
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- Patterson, M. S., Chance, B., & Wilson, B. C. (1989). Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties. Applied Optics. https://doi.org/10.1364/ao.28.002331
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