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Optical measurement of picometer displacements of transparent microscopic objects
Abstract
An optical laser differential interferometer, based on a modified differential interference contrast microscope, has been developed to measure the thermal motion of microscopic protrusions (stereocilia) that are the sites of mechanoelectrical transduction in auditory hair cells. The measurement sensitivity was limited at high frequencies mainly by shot noise, at intermediate frequencies by acoustic interference, and at low frequencies by thermal drift. The power spectral density of the instrumental noise was found to be as low as 1. pm/ radicalHz in the shot noise regime. We could, thus, measure the Brownian motion of hair bundles over the frequency range from 1 Hz-100 kHz. Experimental data that test and demonstrate the sensitivity and spatial discrimination of the instrument were found to be in agreement with theoretical estimates.
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Cited by
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Self-citationDirect observation of kinesin stepping by optical trapping interferometry
Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993) · Nature · doi:10.1038/365721a0 · Cited by 1,910
Force and velocity measured for single kinesin molecules
Svoboda, K., & Block, S. M. (1994) · Cell · doi:10.1016/0092-8674(94)90060-4 · Cited by 909
Three-dimensional optical data storage in refractive media by two-photon point excitation
Strickler, J. H., & Webb, W. W. (1991) · Optics Letters · doi:10.1364/ol.16.001780 · Cited by 627
Self-citationInterference model for back-focal-plane displacement detection in optical tweezers
Gittes, F., & Schmidt, C. F. (1998) · Optics Letters · doi:10.1364/ol.23.000007 · Cited by 623
Metadata
- Authors
- Denk, W., & Webb, W. W.
- Venue
- Applied Optics
- Publisher
- Optica Publishing Group
- Published
- 1990-06-01
- Volume
- 29
- Issue
- 16
- Pages
- 2382
- ISSN
- 0003-6935 (ISSN-L)
- 1539-4522
- OpenAlex
- W2151834147
- Cited by
- 177
- References
- 0
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
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