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Sensitive disk resonator photonic biosensor
Abstract
We describe a photonic device based on a high-finesse, whispering-gallery-mode disk resonator that can be used for the detection of biological pathogens. This device operates by means of monitoring the change in transfer characteristics of the disk resonator when biological materials fall onto its active area. High sensitivity is achieved because the light wave interacts many times with each pathogen as a consequence of the resonant recirculation of light within the disk structure. Specificity of the detected substance can be achieved when a layer of antibodies or other binding material is deposited onto the active area of the resonator. Formulas are presented that allow the sensitivity of the device to be quantified and that show that, under optimum conditions, as few as 100 molecules can be detected.
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Yee, K. (1966) · IEEE Transactions on Antennas and Propagation · doi:10.1109/tap.1966.1138693 · Cited by 15,008
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Iqbal, M., Gleeson, M. A., Spaugh, B., Tybor, F., Gunn, W. G., Hochberg, M., Baehr-Jones, T., Bailey, R. C., & Gunn, L. C. (2010) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2009.2032510 · Cited by 551
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Hunt, H. K., & Armani, A. M. (2010) · Nanoscale · doi:10.1039/c0nr00201a · Cited by 371
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Luchansky, M. S., & Bailey, R. C. (2012) · Analytical Chemistry · doi:10.1021/ac2029024 · Cited by 288
Whispering-gallery-mode electro-optic modulator and photonic microwave receiver
Ilchenko, V. S., Savchenkov, A. A., Matsko, A. B., & Maleki, L. (2003) · Journal of the Optical Society of America B · doi:10.1364/josab.20.000333 · Cited by 177
Metadata
- Authors
- Boyd, R. W., & Heebner, J. E.
- Venue
- Applied Optics
- Publisher
- Optica Publishing Group
- Published
- 2001-11-01
- Volume
- 40
- Issue
- 31
- Pages
- 5742
- ISSN
- 0003-6935 (ISSN-L)
- 1539-4522
- OpenAlex
- W1975760653
- Cited by
- 399
- References
- 1
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boyd, R. W., & Heebner, J. E. (2001). Sensitive disk resonator photonic biosensor. Applied Optics. https://doi.org/10.1364/ao.40.005742
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
