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Cited by 13Optical Coherence Tomography ApplicationsCorneal surgery and disordersOptical Polarization and Ellipsometry

Light scattering from edematous human corneal grafts' microstructure: experimental study and electromagnetic modelization

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Casadessus, Olivier, Georges, Gaëlle, Lamoine, Laure Siozade, Deumié, Carole, Hoffart, Louis·2012·Biomedical Optics Express
DOI 10.1364/boe.3.001793PMC PMC3409700
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Abstract

Along with the lens, the cornea is the only transparent tissue in the human body. However, the development of an edema involves structural disturbances increasing light scattering and leading to the opacification of the cornea. Several mechanisms of transparency loss have been studied in the literature, but the whole phenomenon is complex and the part played by each scatterer is still unclear. We propose here to study human corneal grafts combining microscopic OCT imagery with far-field measurement of the scattered light in the reflected half-space. We introduce afterwards numerical calculations based on electromagnetic equations solved with first order approximation to link the observed microscopic-scale structural modifications with the intensity level of the scattered light, and to try and quantify the relationship between them.

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  • In corneal oedema (bullous keratopathy, Fuch's dystrophy), local decreases in refractive index are caused by pooling of fluid into lakes; the influx of fluid also disrupts fibril organisation and reduces destructive interference of scattered light.

    “A similar effect occurs in corneal oedema (bullous keratopathy, Fuch's dystrophy) but in this case there are local decreases in refractive index caused by pooling of fluid into so-called “lakes” (Casadessus et al., 2012) (Fig. 8). The influx of fluid into the stroma also leads to disruption of the fibril organisation and thus to the reduction in destructive interference of scattered light.”

    From Corneal structure and transparency (2015) · cites this paper as Casadessus et al., 2012

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Research works printed but not linked: 24

  1. [1]T. Nishida, “Cornea: anatomy and physiology,” in Cornea: Fundamentals, Diagnosis and Management, 2nd ed., J. H. Krachmer, M. J. Mannis, and E. J. Holland, eds. (Elsevier/Mosby, 2005).
  2. [2]Maurice D. M., “ The structure and transparency of the cornea,” J. Physiol. 136(2), 263– 286 (1957). 13429485 PMC1358888
  3. [3]Hart R. W. Farrell R. A., “ Light scattering in the cornea,” J. Opt. Soc. Am. 59(6), 766– 774 (1969). 10.1364/JOSA.59.000766 5805456 · DOI · Paper page
  4. [4]Benedek G. B., “ Theory of transparency of the eye,” Appl. Opt. 10(3), 459– 473 (1971). 10.1364/AO.10.000459 20094474 · DOI
  5. [5]Goldman J. N. Benedek G. B. Dohlman C. H. Kravitt B., “ Structural alterations affecting transparency in swollen human corneas,” Invest. Ophthalmol. 7(5), 501– 519 (1968). 5693186
  6. [6]Farrell R. A. McCally R. L. Tatham P. E. R., “ Wave-length dependencies of light scattering in normal and cold swollen rabbit corneas and their structural implications,” J. Physiol. 233(3), 589– 612 (1973). 4754873 PMC1350594
  7. [7]Peyrot D. A. Aptel F. Crotti C. Deloison F. Lemaire S. Marciano T. Bancelin S. Alahyane F. Kowalczuk L. Savoldelli M. Legeais J.-M. Plamann K., “ Effect of incident light wavelength and corneal edema on light scattering and penetration: laboratory study of human corneas,” J. Refract. Surg. 26(10), 786– 795 (2010). 10.3928/1081597X-20100921-04 20954687 · DOI
  8. [8]Jester J. V. Møller-Pedersen T. Huang J. Sax C. M. Kays W. T. Cavangh H. D. Petroll W. M. Piatigorsky J., “ The cellular basis of corneal transparency: evidence for ‘corneal crystallins’,” J. Cell Sci. 112(Pt 5), 613– 622 (1999). 9973596
  9. [9]Møller-Pedersen T., “ Keratocyte reflectivity and corneal haze,” Exp. Eye Res. 78(3), 553– 560 (2004). 10.1016/S0014-4835(03)00208-2 15106935 · DOI · Paper page
  10. [10]Pels E. Beele H. Claerhout I., “ Eye bank issues: II. Preservation techniques: warm versus cold storage,” Int. Ophthalmol. 28(3), 155– 163 (2008). 10.1007/s10792-007-9086-1 17505780 PMC2359829 · DOI
  11. [11]Wolf A. H. Welge-Lüßen U. C. Priglinger S. Kook D. Grueterich M. Hartmann K. Kampik A. Neubauer A. S., “ Optimizing the deswelling process of organ-cultured corneas,” Cornea 28(5), 524– 529 (2009). 10.1097/ICO.0b013e3181901dde 19421045 · DOI
  12. [12]Huang D. Swanson E. A. Lin C. P. Schuman J. S. Stinson W. G. Chang W. Hee M. R. Flotte T. Gregory K. Puliafito C. A. Fujimoto J. G., “ Optical coherence tomography,” Science 254(5035), 1178– 1181 (1991). 10.1126/science.1957169 1957169 PMC4638169 · DOI
  13. [13]Beaurepaire E. Boccara A. C. Lebec M. Blanchot L. Saint-Jalmes H., “ Full-field optical coherence microscopy,” Opt. Lett. 23(4), 244– 246 (1998). 10.1364/OL.23.000244 18084473 · DOI
  14. [14]Dubois A. Vabre L. Boccara A. C. Beaurepaire E., “ High-resolution full-field optical coherence tomography with a Linnik microscope,” Appl. Opt. 41(4), 805– 812 (2002). 10.1364/AO.41.000805 11993929 · DOI
  15. [15]Latour G. Georges G. Lamoine L. S. Deumié C. Conrath J. Hoffart L., “ Human graft cornea and laser incisions imaging with micrometer scale resolution full-field optical coherence tomography,” J. Biomed. Opt. 15(5), 056006 (2010). 10.1117/1.3486544 21054100 · DOI
  16. [16]Amra C. Torricini D. Roche P., “ Multiwavelength (0.45-10.6 µm) angle-resolved scatterometer or how to extend the optical window,” Appl. Opt. 32(28), 5462– 5474 (1993). 10.1364/AO.32.005462 20856357 · DOI
  17. [17]Latour G. Georges G. Siozade-Lamoine L. Deumié C. Conrath J. Hoffart L., “ Light scattering from human corneal grafts: Bulk and surface contribution,” J. Appl. Phys. 108(5), 053104 (2010). 10.1063/1.3452334 · DOI
  18. [18]Amra C. Grèzes-Besset C. Bruel L., “ Comparison of surface and bulk scattering in optical multilayers,” Appl. Opt. 32(28), 5492– 5503 (1993). 10.1364/AO.32.005492 20856360 · DOI
  19. [19]Amra C., “ First-order vector theory of bulk scattering in optical multilayers,” J. Opt. Soc. Am. A 10(2), 365– 374 (1993). 10.1364/JOSAA.10.000365 · DOI
  20. [21]Deumié C. Richier R. Dumas P. Amra C., “ Multiscale roughness in optical multilayers: atomic force microscopy and light scattering,” Appl. Opt. 35(28), 5583– 5594 (1996). 10.1364/AO.35.005583 21127561 · DOI
  21. [22]Patel S. Marshall J. Fitzke F. W. III, “ Refractive index of the human corneal epithelium and stroma,” J. Refract. Surg. 11(2), 100– 105 (1995). 7634138
  22. [23]Meek K. M. Leonard D. W. Connon C. J. Dennis S. Khan S., “ Transparency, swelling and scarring in the corneal stroma,” Eye (Lond.) 17(8), 927– 936 (2003). 10.1038/sj.eye.6700574 14631399 · DOI · Paper page
  23. [24]Popov E. Nevière M., “ Maxwell equations in Fourier space: fast-converging formulation for diffraction by arbitrary shaped, periodic, anisotropic media,” J. Opt. Soc. Am. A 18(11), 2886– 2894 (2001). 10.1364/JOSAA.18.002886 11688878 · DOI
  24. [25]Arnaud L. Georges G. Sorrentini J. Zerrad M. Deumié C. Amra C., “ An enhanced contrast to detect bulk objects under arbitrary rough surfaces,” Opt. Express 17(7), 5758– 5773 (2009). 10.1364/OE.17.005758 19333345 · DOI

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Sorted by citations

Authors
Casadessus, O., Georges, G., Lamoine, L. S., Deumié, C., & Hoffart, L.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Aix-Marseille Université (FR)
Corresponding author
Casadessus, Olivier
ORCID
Hoffart, Louis
Venue
Biomedical Optics Express
Publisher
Optica Publishing Group
Published
2012-07-02
Volume
3
Issue
8
Pages
1793
ISSN
2156-7085 (ISSN-L)
DOI
10.1364/boe.3.001793
PMC
PMC3409700
OpenAlex
W2090155169
Cited by
13
References
0
Citations by year
2026: 1 · 2023: 1 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomedical Optics Express (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
Etablissement Français du Sang
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
  • Physical Sciences › Engineering › Biomedical Engineering › Optical Polarization and Ellipsometry
Keywords
corneal edema, corneal graft, light scattering, corneal microstructure, optical coherence tomography, electromagnetic simulation, first-order approximation, corneal opacity

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