Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy

The maximum sample number for FST V-VI is 6.

“the maximum sample number for FST V–VI is 6.41,42,44,46,48”

At 800 nm, the absorption coefficients described by Tseng et al. were 5-fold greater than those measured by Hsu et al.

“At 800 nm the absorption coefficients described by Tseng et al., were 5-fold greater than those measured by Hsu et al. [55,56].”

Tseng and Hsu's scattering and absorption profiles followed a similar pattern to other authors, with absorption greatest between 500 nm and 600 nm, declining with increasing wavelength except for a small peak at ∼970 nm.

“However, their scattering and absorption profiles followed a similar pattern to the other authors’ with absorption being greatest between 500 nm and 600 nm beyond which it declines steadily with increasing wavelength except for a small peak observed at ∼970 nm.”

Concentrations of tissue chromophores including melanin, haemoglobin, water and lipid can be determined using DRS measurements.

“The concentrations of tissue chromophores including melanin, haemoglobin water and lipid can also be determined using DRS measurements [56].”

A significant peak was observed at 640 nm for the in-vivo data published by Hsu et al.

“However, a significant peak was observed at 640 nm for the in-vivo data published by Hsu et al., potentially representing scattering due to collagen bundles in the skin [56].”

The 640 nm peak in Hsu et al. data potentially represents scattering due to collagen bundles in the skin.

“potentially representing scattering due to collagen bundles in the skin [56].”