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Cited by 186

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Molecular specific optoacoustic imaging with plasmonic nanoparticles

Open access
Mallidi, Srivalleesha, Larson, Timothy, Aaron, Jesse, Sokolov, Konstantin, Emelianov, Stanislav·2007·Optics Express

Abstract

Gold nanoparticles functionalized with antibodies can specifically bind to molecular biomarkers such as epithelial growth factor receptor (EGFR). The molecule specific nature of the antibody-functionalized gold nanoparticles forms the basis for the developed optoacoustic imaging technique to detect cancer at an asymptotic stage. Optoacoustic imaging was performed with 532 nm and 680 nm pulsed laser irradiation on three-dimensional tissue phantoms prepared using a human keratinocyte cell line. The results of our study demonstrate that the combination of anti-EGFR gold ioconjugates and optoacoustic imaging can allow highly sensitive and selective detection of human epithelial cancer cells.

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Metadata

Authors
Mallidi, S., Larson, T., Aaron, J., Sokolov, K., & Emelianov, S.
Venue
Optics Express
Published
2007
Volume
15
Issue
11
Pages
6583
ISSN
1094-4087 (ISSN-L)
OpenAlex
W2014077561
Cited by
186
References
0
FWCI
13.26
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Molecular specific optoacoustic imaging with plasmonic nanoparticles. https://app.cochat.ai/papers/10.1364/oe.15.006583
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Mallidi, S., Larson, T., Aaron, J., Sokolov, K., & Emelianov, S. (2007). Molecular specific optoacoustic imaging with plasmonic nanoparticles. Optics Express. https://doi.org/10.1364/oe.15.006583

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