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In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agents
Abstract
A new photoacoustic flow cytometry was developed for real-time detection of circulating cells, nanoparticles, and contrast agents in vivo. Its capability, integrated with photothermal and optical clearing methods, was demonstrated using a near-infrared tunable laser to characterize the in vivo kinetics of Indocyanine Green alone and single cancer cells labeled with gold nanorods and Indocyanine Green in the vasculature of the mouse ear. In vivo applications are discussed, including selective nanophotothermolysis of metastatic squamous cells, label-free detection of melanoma cells, study of pharmokinetics, and immune response to apoptotic and necrotic cells, with potential translation to humans. The threshold sensitivity is estimated as one cancer cell in the background of 10(7) normal blood cells.
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Research works printed but not linked: 5
- Novak, 2004, Opt. Lett., 29, 77, 10.1364/OL.29.000077 · DOI · Paper page
- Zharov, 2004, Proc. SPIE, 5320, 256
- Zharov, 2006, J. Cell. Biochem., 97, 916, 10.1002/jcb.20766 · doi:10.1002/jcb.20766
- Wang, 2004, Opt. Lett., 29, 730, 10.1364/OL.29.000730 · doi:10.1364/ol.29.000730
- Wei, 2003, Invest. Ophthalmol. Visual Sci., 44, 4489, 10.1167/iovs.03-0041 · doi:10.1167/iovs.03-0041
Cited by
Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents
Kim, J.-W., Galanzha, E. I., Shashkov, E. V., Moon, H.-M., & Zharov, V. P. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.231 · Cited by 710
Self-citationTransverse flow imaging based on photoacoustic Doppler bandwidth broadening
Yao, J., & Wang, L. V. (2010) · Journal of Biomedical Optics · doi:10.1117/1.3339953 · Cited by 75
Wang, H., Liao, R., Xiong, Z., Wang, Z., Li, J., Zhou, Q., Tao, Y., & Ma, H. (2022) · Biosensors · doi:10.3390/bios12030176 · Cited by 10
“With the labeling of the contrast agents, some literature studies report applying laser-induced acoustic measurement to assess the circulating metastatic melanoma cells in blood [25,26].”
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Metadata
- Authors
- Zharov, V. P., Galanzha, E. I., Shashkov, E. V., Khlebtsov, N. G., & Tuchin, V. V.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2006-11-22
- Volume
- 31
- Issue
- 24
- Pages
- 3623
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2024391597
- Cited by
- 229
- References
- 0
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- doi.org/10.1364/OA_License_v1#VOR (vor)
- opg.optica.org/policies/opg-tdm-policy.json (tdm)
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- Zharov, V. P., Galanzha, E. I., Shashkov, E. V., Khlebtsov, N. G., & Tuchin, V. V. (2006). In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agents. Optics Letters. https://doi.org/10.1364/ol.31.003623
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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