The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo
Open accessAbstract
Optical absorption provides essential biological functional information but cannot be sensed by mainstream optical microscopy technologies directly, which detect fluorescence or scattering and may require undesirable labeling. Here we developed in vivo subwavelength-resolution photoacoustic microscopy (SW-PAM) that provides exquisitely high optical-absorption contrast due to nonfluorescent, or fluorescent, endogenous pigments. Having approached the ultimate diffraction-limited optical resolution, SW-PAM can resolve subcellular organelles. Vasculature and early-stage melanoma were imaged with 12:1 and 17:1 contrasts, respectively, without labeling. SW-PAM along with the scaled-up macroscopy, as the only technology that measures the same contrast origin over such a wide length scale, can potentially accelerate translation from microscopic research to clinical practice.
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Melanoma biology and new targeted therapy
Gray-Schopfer, V., Wellbrock, C., & Marais, R. (2007) · Nature · doi:10.1038/nature05661 · Cited by 1,371
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Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Self-citationYao, J., & Wang, L. V. (2013) · Laser & Photonics Reviews · doi:10.1002/lpor.201200060 · Cited by 616
Self-citationSimultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo
Yang, J.-M., Favazza, C., Chen, R., Yao, J., Cai, X., Maslov, K., Zhou, Q., Shung, K. K., & Wang, L. V. (2012) · Nature Medicine · doi:10.1038/nm.2823 · Cited by 429
Self-citationA review of melanin sensor devices
Kanellis, V. G. (2019) · Biophysical Reviews · doi:10.1007/s12551-019-00581-8 · Cited by 29
Metadata
- Authors
- Zhang, C., Maslov, K., & Wang, L. V.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2010-09-21
- Volume
- 35
- Issue
- 19
- Pages
- 3195
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2061707289
- Cited by
- 281
- References
- 1
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, C., Maslov, K., & Wang, L. V. (2010). Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo. Optics Letters. https://doi.org/10.1364/ol.35.003195
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