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Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed
Open accessAbstract
We developed second-generation (G2) optical-resolution photoacoustic microscopy (OR-PAM). Incorporation of a novel acoustic detection scheme improved upon the sensitivity of our first-generation (G1) system by 18.4 dB, deepening the in vivo tissue penetration to 1.2 mm at 570 nm. Moreover, translating the imaging head instead of the living object accelerated the scanning speed by a factor of 5, widening the field of view within the same acquisition time. Mouse ears, as well as mouse brains with intact craniums, were imaged in vivo in both total concentration and oxygen saturation of hemoglobin.
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Citations
Cited by
Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Self-citationYao, J., & Wang, L. V. (2013) · Laser & Photonics Reviews · doi:10.1002/lpor.201200060 · Cited by 616
Self-citationOptical coherence tomography today: speed, contrast, and multimodality
Drexler, W., Liu, M., Kumar, A., Kamali, T., Unterhuber, A., & Leitgeb, R. A. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.7.071412 · Cited by 473
Ultrasensitive plano-concave optical microresonators for ultrasound sensing
Guggenheim, J. A., Li, J., Allen, T. J., Colchester, R. J., Noimark, S., Ogunlade, O., Parkin, I. P., Papakonstantinou, I., Desjardins, A. E., Zhang, E. Z., et al. (2017) · Nature Photonics · doi:10.1038/s41566-017-0027-x · Cited by 391
Metadata
- Authors
- Hu, S., Maslov, K., & Wang, L. V.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2011-03-23
- Volume
- 36
- Issue
- 7
- Pages
- 1134
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W1982367678
- Cited by
- 429
- References
- 0
- FWCI
- 17.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hu, S., Maslov, K., & Wang, L. V. (2011). Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed. Optics Letters. https://doi.org/10.1364/ol.36.001134
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
