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Noninvasive Raman Spectroscopy of Human Tissue in vivo
Abstract
We report the first transcutaneous Raman spectrum of human bone in vivo obtained at skin-safe laser illumination levels. The spectrum of thumb distal phalanx was obtained using spatially offset Raman spectroscopy (SORS), which provides chemically specific information on deep layers of human tissue, well beyond the reach of existing comparative approaches. The spectroscopy is based on collecting Raman spectra away from the point of laser illumination using concentric rings of optical fibers. As a generic analytical tool this approach paves the way for a range of uses including disease diagnosis, noninvasive probing of pharmaceutical products, biofilms, catalysts, paints, and in dermatological applications.
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Cited by
Using Raman spectroscopy to characterize biological materials
Butler, H. J., Ashton, L., Bird, B., Cinque, G., Curtis, K., Dorney, J., Esmonde-White, K., Fullwood, N. J., Gardner, B., Martin-Hirsch, P. L., et al. (2016) · Nature Protocols · doi:10.1038/nprot.2016.036 · Cited by 1,309
Raman Assessment of Bone Quality
Morris, M. D., & Mandair, G. S. (2011) · Clinical Orthopaedics & Related Research · doi:10.1007/s11999-010-1692-y · Cited by 511
Raman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 396
Raman and CARS microspectroscopy of cells and tissues
Krafft, C., Dietzek, B., & Popp, J. (2009) · The Analyst · doi:10.1039/b822354h · Cited by 271
Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging – the next dimension
Stone, N., Kerssens, M., Lloyd, G. R., Faulds, K., Graham, D., & Matousek, P. (2011) · Chemical Science · doi:10.1039/c0sc00570c · Cited by 183
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Metadata
- Authors
- Matousek, P., Draper, E. R. C., Goodship, A. E., Clark, I. P., Ronayne, K. L., & Parker, A. W.
- Venue
- Applied Spectroscopy
- Publisher
- SAGE Publications
- Published
- 2006-07
- Volume
- 60
- Issue
- 7
- Pages
- 758-763
- ISSN
- 0003-7028 (ISSN-L)
- 1943-3530
- OpenAlex
- W2031838608
- Cited by
- 219
- References
- 0
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Matousek, P., Draper, E. R. C., Goodship, A. E., Clark, I. P., Ronayne, K. L., & Parker, A. W. (2006). Noninvasive Raman Spectroscopy of Human Tissue in vivo. Applied Spectroscopy. https://doi.org/10.1366/000370206777886955
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