The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Heparan Sulfate Biosynthesis: Regulation and Variability
Open accessAbstract
Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans (HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including numerous growth factors, cytokines, and morphogens, to affect their tissue distribution and signaling. The heparan sulfate (HS) chains may have variable length and may differ with regard to both degree and pattern of sulfation. As the sulfation pattern of HS chains in most cases will determine if an interaction with a potential ligand will take place, as well as the affinity of the interaction, a key to understanding the function of HSPGs is to clarify how HS biosynthesis is regulated in different biological contexts. This review provides an introduction to the current understanding of HS biosynthesis and its regulation, and identifies research areas where more knowledge is needed to better understand how the HS biosynthetic machinery works.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate
Esko, J. D., & Selleck, S. B. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135458 · Cited by 1,495
Schlessinger, J., Plotnikov, A. N., Ibrahimi, O. A., Eliseenkova, A. V., Yeh, B. K., Yayon, A., Linhardt, R. J., & Mohammadi, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00073-3 · Cited by 1,199
A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry
Shukla, D., Liu, J., Blaiklock, P., Shworak, N. W., Bai, X., Esko, J. D., Cohen, G. H., Eisenberg, R. J., Rosenberg, R. D., & Spear, P. G. (1999) · Cell · doi:10.1016/s0092-8674(00)80058-6 · Cited by 1,054
Molecular diversity of heparan sulfate
Esko, J. D., & Lindahl, U. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13530 · Cited by 951
Heparan sulphate proteoglycans: the sweet side of development
Häcker, U., Nybakken, K., & Perrimon, N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1681 · Cited by 683
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
Iozzo, R. V., & Sanderson, R. D. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01236.x · Cited by 569
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
Forsberg, E., Pejler, G., Ringvall, M., Lunderius, C., Tomasini-Johansson, B., Kusche-Gullberg, M., Eriksson, I., Ledin, J., Hellman, L., & Kjellén, L. (1999) · Nature · doi:10.1038/23488 · Cited by 481
Self-citationMcCormick, C., Duncan, G., Goutsos, K. T., & Tufaro, F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.668 · Cited by 450
Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate
Inatani, M., Irie, F., Plump, A. S., Tessier-Lavigne, M., & Yamaguchi, Y. (2003) · Science · doi:10.1126/science.1090497 · Cited by 431
Heparin is essential for the storage of specific granule proteases in mast cells
Humphries, D. E., Wong, G. W., Friend, D. S., Gurish, M. F., Qiu, W.-T., Huang, C., Sharpe, A. H., & Stevens, R. L. (1999) · Nature · doi:10.1038/23481 · Cited by 428
Research works printed but not linked: 5
- 10.1172/JCI200113530 · doi:10.1172/jci200113530 · Paper page
- 10.1172/JCI200315809 · DOI
- 10.1016/0014-5793(75)80781-2 · doi:10.1016/0014-5793(75)80781-2
- 10.1042/bj3630263 · DOI
- Velasco A, 1988, Eur J Cell Biol, 47, 241
Cited by
Demystifying Heparan Sulfate–Protein Interactions
Xu, D., & Esko, J. D. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035314 · Cited by 805
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)
Rauch, J. N., Chen, J. J., Sorum, A. W., Miller, G. M., Sharf, T., See, S. K., Hsieh-Wilson, L. C., Kampmann, M., & Kosik, K. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-24904-z · Cited by 211
Elgundi, Z., Papanicolaou, M., Major, G., Cox, T. R., Melrose, J., Whitelock, J. M., & Farrugia, B. L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01482 · Cited by 176
Keenan, T. D. L., Pickford, C. E., Holley, R. J., Clark, S. J., Lin, W., Dowsey, A. W., Merry, C. L., Day, A. J., & Bishop, P. N. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.14-14126 · Cited by 65
Blanchard, D. C., Summers, C. H., & Blanchard, R. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.008 · Cited by 60
Metadata
- Authors
- Kreuger, J., & Kjellén, L.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 2012-10-04
- Volume
- 60
- Issue
- 12
- Pages
- 898-907
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2025174538
- Cited by
- 301
- References
- 97
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Heparan Sulfate Biosynthesis: Regulation and Variability. https://app.cochat.ai/papers/10.1369/0022155412464972
- The paper
- Kreuger, J., & Kjellén, L. (2012). Heparan Sulfate Biosynthesis: Regulation and Variability. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1369/0022155412464972
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
