The role of behavior in translational models for psychopathology: functionality and dysfunctional behaviors
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The history of science has frequently included a problem-based impetus toward research that can be translated expeditiously into solutions. A current problem is that psychopathologies, typically chronic, contribute hugely to the economic and social burden of medical care, especially in the United States. For behavioral neuroscientists a psychopathology-aimed translational research emphasis particularly involves animal models to facilitate the experimental and invasive work necessary to an understanding of the biology of normal and aberrant behavior. When the etiology of a particular psychopathology is unknown, and there are no specific biomarkers, behavioral parallels between the focal disorder and its putative models become crucial elements in assessing model validity. Evaluation of these parallels is frequently neglected, reflecting in part the lack of a systematic conceptualization of the organization of behavior and how this may be conserved across species. Recent work specifically attempting to bridge this gap suggests that analysis of behaviors that are functional - adaptive in crucial situations such as danger or social contexts - can facilitate an understanding of the parallels between behaviors of human and nonhuman species, including the dysfunctional behaviors of psycho pathologies. As research with animal models comes to provide a more systematic analysis of particular behaviors and their adaptive functions, cross-talk between model and focal psychopathology may be advantageous to understanding both.
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Understanding of the ethology of mice and rats in the wild is still lacking, and this gap has been acknowledged as a major challenge in the field.
“Unfortunately, understanding of the ethology of mice and rats in the wild is still lacking, and this gap in knowledge and methodology has been acknowledged as a major challenge in the field (Anderson and Perona, 2014, Blanchard et al., 2013, Kondrakiewicz et al., 2019).”
From Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors (2020) · cites this paper as Blanchard et al., 2013
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OSERR: an open-source standalone electrophysiology recording system for rodents
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The Neuroscience Community Has a Role in Environmental Conservation
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Aggression as a contributing factor to social defeat and stress vulnerability
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Leveraging interindividual variability in threat conditioning of inbred mice to model trait anxiety
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- Authors
- Blanchard, D. C., Summers, C. H., & Blanchard, R. J.
- Affiliations
- University of South Dakota (US)
- University of Hawaiʻi at Mānoa (US)
- Corresponding author
- Blanchard, D. Caroline
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 37
- Issue
- 8
- Pages
- 1567-1577
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC3800172
- OpenAlex
- W2007701150
- Cited by
- 60
- References
- 83
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH081845)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Keywords
- psychopathology, animal models of psychopathology, translational research, functional behavior, dysfunctional behavior, model validity, adaptive behavior, psychobiology, social behavior, economic burden of mental illness
- MeSH terms
- Animals, Mental Disorders, Disease Models, Animal, Humans, Translational Research, Biomedical
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